Astragalus polysaccharide modulates the gut microbiota and metabolites of patients with major depressive disorder in an in vitro fermentation model: a pilot study

Astragalus polysaccharide modulates the gut microbiota and metabolites of patients with major depressive disorder in an in vitro fermentation model: a pilot study

Previous studies have found that Astragalus Polysaccharide (APS) and Lactobacillus plantarum PS128 (PS128) have potential antidepressant effects, but their effects on the gut microbiota and metabolites of major depressive disorder (MDD) are still unclear. We examined the effect of APS on gut microbi...

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Bibliographic Details
Main Authors: Yuwei Mi, Chen Lin, Huowang Zheng, Ying Wu, Yanbin Hou, Jieqiong Hu, Jiaxin Mao, Ni Dai, Xiaoqiong Li, Zhongze Lou, Yunxin Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Nutrition
Subjects:
Astragalus polysaccharide
Lactobacillus plantarum PS128
depression
gut microbiota
tryptophan
metabolites
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2025.1587742/full
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