Recent advances in the prevention of secondary ischemic stroke: A narrative review
Stroke remains a significant contributor to global morbidity and mortality, with acute ischemic stroke comprising the majority of cases. Secondary stroke, the recurrent stroke, is often more severe and linked to worse functional outcomes and increased mortality. The secondary prevention of ischemic...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
|
| Series: | Brain Circulation |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/bc.bc_159_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841556941548027904 |
|---|---|
| author | Yue Qiao Aminah I. Fayyaz Yuchuan Ding Xunming Ji Wenbo Zhao |
| author_facet | Yue Qiao Aminah I. Fayyaz Yuchuan Ding Xunming Ji Wenbo Zhao |
| author_sort | Yue Qiao |
| collection | DOAJ |
| description | Stroke remains a significant contributor to global morbidity and mortality, with acute ischemic stroke comprising the majority of cases. Secondary stroke, the recurrent stroke, is often more severe and linked to worse functional outcomes and increased mortality. The secondary prevention of ischemic stroke is crucial for reducing the risk of recurrent events. Significant advancements have been made in secondary prevention strategies in recent years. These include the refinement of antithrombotic regimens, the use of direct oral anticoagulants in managing atrial fibrillation, and the implementation of more aggressive targets for blood pressure, lipid management, and glucose management. Furthermore, emerging therapeutic approaches, such as remote ischemic conditioning and anti-inflammatory agents such as colchicine, have shown promise in reducing stroke recurrence through nontraditional mechanisms. This review summarizes the latest advancements in the secondary prevention of ischemic stroke over the past 5 years, highlighting the key clinical trials and novel interventions. The optimization of traditional risk factor management and the emergence of novel therapeutic methods have provided more options for clinical practice. Future research should focus on identifying the optimal treatment strategies for specific patient subgroups and the clinical translation and application of new therapeutic methods. |
| format | Article |
| id | doaj-art-61157a6eae814500a3ac8aa4a0629569 |
| institution | Kabale University |
| issn | 2455-4626 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Brain Circulation |
| spelling | doaj-art-61157a6eae814500a3ac8aa4a06295692025-01-07T05:14:06ZengWolters Kluwer Medknow PublicationsBrain Circulation2455-46262024-12-0110428329510.4103/bc.bc_159_24Recent advances in the prevention of secondary ischemic stroke: A narrative reviewYue QiaoAminah I. FayyazYuchuan DingXunming JiWenbo ZhaoStroke remains a significant contributor to global morbidity and mortality, with acute ischemic stroke comprising the majority of cases. Secondary stroke, the recurrent stroke, is often more severe and linked to worse functional outcomes and increased mortality. The secondary prevention of ischemic stroke is crucial for reducing the risk of recurrent events. Significant advancements have been made in secondary prevention strategies in recent years. These include the refinement of antithrombotic regimens, the use of direct oral anticoagulants in managing atrial fibrillation, and the implementation of more aggressive targets for blood pressure, lipid management, and glucose management. Furthermore, emerging therapeutic approaches, such as remote ischemic conditioning and anti-inflammatory agents such as colchicine, have shown promise in reducing stroke recurrence through nontraditional mechanisms. This review summarizes the latest advancements in the secondary prevention of ischemic stroke over the past 5 years, highlighting the key clinical trials and novel interventions. The optimization of traditional risk factor management and the emergence of novel therapeutic methods have provided more options for clinical practice. Future research should focus on identifying the optimal treatment strategies for specific patient subgroups and the clinical translation and application of new therapeutic methods.https://journals.lww.com/10.4103/bc.bc_159_24antithrombotic therapyblood pressure managementlipid managementnovel therapeuticssecondary stroke |
| spellingShingle | Yue Qiao Aminah I. Fayyaz Yuchuan Ding Xunming Ji Wenbo Zhao Recent advances in the prevention of secondary ischemic stroke: A narrative review Brain Circulation antithrombotic therapy blood pressure management lipid management novel therapeutics secondary stroke |
| title | Recent advances in the prevention of secondary ischemic stroke: A narrative review |
| title_full | Recent advances in the prevention of secondary ischemic stroke: A narrative review |
| title_fullStr | Recent advances in the prevention of secondary ischemic stroke: A narrative review |
| title_full_unstemmed | Recent advances in the prevention of secondary ischemic stroke: A narrative review |
| title_short | Recent advances in the prevention of secondary ischemic stroke: A narrative review |
| title_sort | recent advances in the prevention of secondary ischemic stroke a narrative review |
| topic | antithrombotic therapy blood pressure management lipid management novel therapeutics secondary stroke |
| url | https://journals.lww.com/10.4103/bc.bc_159_24 |
| work_keys_str_mv | AT yueqiao recentadvancesinthepreventionofsecondaryischemicstrokeanarrativereview AT aminahifayyaz recentadvancesinthepreventionofsecondaryischemicstrokeanarrativereview AT yuchuanding recentadvancesinthepreventionofsecondaryischemicstrokeanarrativereview AT xunmingji recentadvancesinthepreventionofsecondaryischemicstrokeanarrativereview AT wenbozhao recentadvancesinthepreventionofsecondaryischemicstrokeanarrativereview |