An immune activator encapsulating PD-L1 siRNA for augmented immune checkpoint blockade immunotherapy through Zn2+ overload triggered pyroptosis

An immune activator encapsulating PD-L1 siRNA for augmented immune checkpoint blockade immunotherapy through Zn2+ overload triggered pyroptosis

Abstract Breast cancer as a “cold” tumor presents an immunosuppressive microenvironment and inferior T-lymphocyte infiltration, leading to poor efficacy of immune checkpoint blockade (ICB) therapies. It is urgent to develop new effective combination treatment strategies. Pyroptosis is an inflammator...

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Bibliographic Details
Main Authors: Liming Gong, Yanhong Liu, Jing Feng, Congcong Xiao, Chenfei Liu, Bohan Chen, Liqing Chen, Mingji Jin, Youyan Guan, Zhonggao Gao, Wei Huang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Nanobiotechnology
Subjects:
Pyroptosis
Immune activator
Immune checkpoint blockade
Anti-tumor immunotherapy
Online Access:https://doi.org/10.1186/s12951-025-03521-9
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