Exploiting haem-iron dependence of nontypeable Haemophilus influenzae: an avenue for future therapeutic development
Nontypeable Haemophilus influenzae (NTHi) is a major respiratory pathogen that imposes a substantial disease burden, globally. Further amplifying the burden of NTHi-associated infections is the rapidly expanding spectrum and prevalence of antibiotic resistance, and the lack of an effective vaccinati...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1548048/full |
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| author | Brianna Atto David A. Gell Robyn Marsh Robyn Marsh Stephen Tristram |
| author_facet | Brianna Atto David A. Gell Robyn Marsh Robyn Marsh Stephen Tristram |
| author_sort | Brianna Atto |
| collection | DOAJ |
| description | Nontypeable Haemophilus influenzae (NTHi) is a major respiratory pathogen that imposes a substantial disease burden, globally. Further amplifying the burden of NTHi-associated infections is the rapidly expanding spectrum and prevalence of antibiotic resistance, and the lack of an effective vaccination strategy. In 2017, the World Health Organization list of “priority pathogens”, highlighted the urgent need for new therapeutic agents against NTHi. Consequently, alternative preventative or treatment approaches that do not rely on antibiotic susceptibility or stable vaccine targets are becoming more attractive. The nutritional dependency for haem/iron at all stages of NTHi pathogenesis exposes a vulnerability that may be exploited for the development of such therapies. This review explores the role of haem/iron in all facets of NTHi pathogenesis, the host-bacterial competition for this vital nutrient, and the therapeutic potential of strategies that interfere with its acquisition. |
| format | Article |
| id | doaj-art-610d8b8b27c149d2b1ffc91160a02f25 |
| institution | DOAJ |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-610d8b8b27c149d2b1ffc91160a02f252025-08-20T03:10:05ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-05-011510.3389/fcimb.2025.15480481548048Exploiting haem-iron dependence of nontypeable Haemophilus influenzae: an avenue for future therapeutic developmentBrianna Atto0David A. Gell1Robyn Marsh2Robyn Marsh3Stephen Tristram4School of Health Sciences, University of Tasmania, Launceston, TAS, AustraliaMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, AustraliaSchool of Health Sciences, University of Tasmania, Launceston, TAS, AustraliaChild and Maternal Health Division, Menzies School of Health Research, Darwin, NT, AustraliaSchool of Health Sciences, University of Tasmania, Launceston, TAS, AustraliaNontypeable Haemophilus influenzae (NTHi) is a major respiratory pathogen that imposes a substantial disease burden, globally. Further amplifying the burden of NTHi-associated infections is the rapidly expanding spectrum and prevalence of antibiotic resistance, and the lack of an effective vaccination strategy. In 2017, the World Health Organization list of “priority pathogens”, highlighted the urgent need for new therapeutic agents against NTHi. Consequently, alternative preventative or treatment approaches that do not rely on antibiotic susceptibility or stable vaccine targets are becoming more attractive. The nutritional dependency for haem/iron at all stages of NTHi pathogenesis exposes a vulnerability that may be exploited for the development of such therapies. This review explores the role of haem/iron in all facets of NTHi pathogenesis, the host-bacterial competition for this vital nutrient, and the therapeutic potential of strategies that interfere with its acquisition.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1548048/fullhaem acquisitionnew therapeutic agentsnontypeable H. influenzaerespiratory infectionsironhost-pathogen interactions |
| spellingShingle | Brianna Atto David A. Gell Robyn Marsh Robyn Marsh Stephen Tristram Exploiting haem-iron dependence of nontypeable Haemophilus influenzae: an avenue for future therapeutic development Frontiers in Cellular and Infection Microbiology haem acquisition new therapeutic agents nontypeable H. influenzae respiratory infections iron host-pathogen interactions |
| title | Exploiting haem-iron dependence of nontypeable Haemophilus influenzae: an avenue for future therapeutic development |
| title_full | Exploiting haem-iron dependence of nontypeable Haemophilus influenzae: an avenue for future therapeutic development |
| title_fullStr | Exploiting haem-iron dependence of nontypeable Haemophilus influenzae: an avenue for future therapeutic development |
| title_full_unstemmed | Exploiting haem-iron dependence of nontypeable Haemophilus influenzae: an avenue for future therapeutic development |
| title_short | Exploiting haem-iron dependence of nontypeable Haemophilus influenzae: an avenue for future therapeutic development |
| title_sort | exploiting haem iron dependence of nontypeable haemophilus influenzae an avenue for future therapeutic development |
| topic | haem acquisition new therapeutic agents nontypeable H. influenzae respiratory infections iron host-pathogen interactions |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1548048/full |
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