Hypercoagulability Is a Stronger Risk Factor for Ischaemic Stroke than for Myocardial Infarction: A Systematic Review.
<h4>Background and purpose</h4>Hypercoagulability increases the risk of arterial thrombosis; however, this effect may differ between various manifestations of arterial disease.<h4>Methods</h4>In this study, we compared the effect of coagulation factors as measures of hypercoa...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0133523 |
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| Summary: | <h4>Background and purpose</h4>Hypercoagulability increases the risk of arterial thrombosis; however, this effect may differ between various manifestations of arterial disease.<h4>Methods</h4>In this study, we compared the effect of coagulation factors as measures of hypercoagulability on the risk of ischaemic stroke (IS) and myocardial infarction (MI) by performing a systematic review of the literature. The effect of a risk factor on IS (relative risk for IS, RRIS) was compared with the effect on MI (RRMI) by calculating their ratio (RRR = RRIS/RRMI). A relevant differential effect was considered when RRR was >1+ its own standard error (SE) or <1-SE.<h4>Results</h4>We identified 70 publications, describing results from 31 study populations, accounting for 351 markers of hypercoagulability. The majority (203/351, 58%) had an RRR greater than 1. A larger effect on IS risk than MI risk (RRE>1+1SE) was found in 49/343 (14%) markers. Of these, 18/49 (37%) had an RRR greater than 1+2SE. On the opposite side, a larger effect on MI risk (RRR<1-1SE) was found in only 17/343 (5%) markers.<h4>Conclusions</h4>These results suggest that hypercoagulability has a more pronounced effect on the risk of IS than that of MI. |
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| ISSN: | 1932-6203 |