Evaluation of the Hepatoprotective Properties of Traditional Formulations Based on Cochlospermum tinctorium Used in Benin
Hepatic diseases represent a public health problem. Among the approaches to their management is the use of traditional treatments based on the use of medicinal plants. In Benin, several recipes based on Cochlospermum tinctorium are used in the treatment of hepatitis without a real scientific basis....
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Advances in Pharmacological and Pharmaceutical Sciences |
| Online Access: | http://dx.doi.org/10.1155/2024/7753008 |
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| author | Appolinaire K. Dossa Jean Robert Klotoé Victorien Dougnon Eric Agbodjento Rémi Akotègnon Fréjus Ohouko Manoir Hounkanrin Kévine Vodounnon Luc V. C. Brun Fréderic Loko |
| author_facet | Appolinaire K. Dossa Jean Robert Klotoé Victorien Dougnon Eric Agbodjento Rémi Akotègnon Fréjus Ohouko Manoir Hounkanrin Kévine Vodounnon Luc V. C. Brun Fréderic Loko |
| author_sort | Appolinaire K. Dossa |
| collection | DOAJ |
| description | Hepatic diseases represent a public health problem. Among the approaches to their management is the use of traditional treatments based on the use of medicinal plants. In Benin, several recipes based on Cochlospermum tinctorium are used in the treatment of hepatitis without a real scientific basis. This study aimed to evaluate the hepatoprotective effects and acute oral toxicity of 10 of these recipes. The variables studied were the variety of C. tinctorium (wild form vs. cultivated form), the species associated with C. tinctorium (Combretum micranthum vs. Chromolaena odorata), and the proportion of C. tinctorium in the recipe (1; 4/5; 1/2). The hepatoprotective effect of these extracts at doses of 100, 200, and 400 mg/kg/bw was evaluated in Wistar rats subjected to hepatotoxicity induction through the administration of 5 g/kg of paracetamol. Acute oral toxicity was assessed following the OECD 423 protocol. The results revealed an absence of acute oral toxicity for the 10 recipes. The hepatoprotective tests conducted indicated that the hepatoprotective effect of C. tinctorium is dose dependent. The wild variety of C. tinctorium had a better hepatoprotective effect than the cultivated one. The association with C. micranthum enhances the hepatoprotective effect of C. tinctorium, unlike that with C. odorata. This study emphasizes that the combination of C. tinctorium with C. micranthum in the treatment of hepatitis is scientifically justified and it exhibits a dose-dependent hepatoprotective effect. |
| format | Article |
| id | doaj-art-6106b8d0861d418ebbfb640532c79446 |
| institution | Kabale University |
| issn | 2633-4690 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological and Pharmaceutical Sciences |
| spelling | doaj-art-6106b8d0861d418ebbfb640532c794462025-01-03T01:41:03ZengWileyAdvances in Pharmacological and Pharmaceutical Sciences2633-46902024-01-01202410.1155/2024/7753008Evaluation of the Hepatoprotective Properties of Traditional Formulations Based on Cochlospermum tinctorium Used in BeninAppolinaire K. Dossa0Jean Robert Klotoé1Victorien Dougnon2Eric Agbodjento3Rémi Akotègnon4Fréjus Ohouko5Manoir Hounkanrin6Kévine Vodounnon7Luc V. C. Brun8Fréderic Loko9Research Unit in Applied Microbiology and Pharmacology of Natural SubstancesResearch Unit in Applied Microbiology and Pharmacology of Natural SubstancesResearch Unit in Applied Microbiology and Pharmacology of Natural SubstancesResearch Unit in Applied Microbiology and Pharmacology of Natural SubstancesResearch Unit in Applied Microbiology and Pharmacology of Natural SubstancesResearch Unit in Applied Microbiology and Pharmacology of Natural SubstancesResearch Unit in Applied Microbiology and Pharmacology of Natural SubstancesResearch Unit in Applied Microbiology and Pharmacology of Natural SubstancesCytology and Anatomy Pathology LaboratoryResearch Unit in Applied Microbiology and Pharmacology of Natural SubstancesHepatic diseases represent a public health problem. Among the approaches to their management is the use of traditional treatments based on the use of medicinal plants. In Benin, several recipes based on Cochlospermum tinctorium are used in the treatment of hepatitis without a real scientific basis. This study aimed to evaluate the hepatoprotective effects and acute oral toxicity of 10 of these recipes. The variables studied were the variety of C. tinctorium (wild form vs. cultivated form), the species associated with C. tinctorium (Combretum micranthum vs. Chromolaena odorata), and the proportion of C. tinctorium in the recipe (1; 4/5; 1/2). The hepatoprotective effect of these extracts at doses of 100, 200, and 400 mg/kg/bw was evaluated in Wistar rats subjected to hepatotoxicity induction through the administration of 5 g/kg of paracetamol. Acute oral toxicity was assessed following the OECD 423 protocol. The results revealed an absence of acute oral toxicity for the 10 recipes. The hepatoprotective tests conducted indicated that the hepatoprotective effect of C. tinctorium is dose dependent. The wild variety of C. tinctorium had a better hepatoprotective effect than the cultivated one. The association with C. micranthum enhances the hepatoprotective effect of C. tinctorium, unlike that with C. odorata. This study emphasizes that the combination of C. tinctorium with C. micranthum in the treatment of hepatitis is scientifically justified and it exhibits a dose-dependent hepatoprotective effect.http://dx.doi.org/10.1155/2024/7753008 |
| spellingShingle | Appolinaire K. Dossa Jean Robert Klotoé Victorien Dougnon Eric Agbodjento Rémi Akotègnon Fréjus Ohouko Manoir Hounkanrin Kévine Vodounnon Luc V. C. Brun Fréderic Loko Evaluation of the Hepatoprotective Properties of Traditional Formulations Based on Cochlospermum tinctorium Used in Benin Advances in Pharmacological and Pharmaceutical Sciences |
| title | Evaluation of the Hepatoprotective Properties of Traditional Formulations Based on Cochlospermum tinctorium Used in Benin |
| title_full | Evaluation of the Hepatoprotective Properties of Traditional Formulations Based on Cochlospermum tinctorium Used in Benin |
| title_fullStr | Evaluation of the Hepatoprotective Properties of Traditional Formulations Based on Cochlospermum tinctorium Used in Benin |
| title_full_unstemmed | Evaluation of the Hepatoprotective Properties of Traditional Formulations Based on Cochlospermum tinctorium Used in Benin |
| title_short | Evaluation of the Hepatoprotective Properties of Traditional Formulations Based on Cochlospermum tinctorium Used in Benin |
| title_sort | evaluation of the hepatoprotective properties of traditional formulations based on cochlospermum tinctorium used in benin |
| url | http://dx.doi.org/10.1155/2024/7753008 |
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