Changes in Ocular Biometry After Pharmacologic Cycloplegia and Mydriasis in Primary Angle Closure Disease
Abstract Introduction The mechanism of primary angle closure disease (PACD) has been extensively investigated, while some cases remain unexplained. Hypothesizing that chronic primary ciliary block (CB) may play a role in PACD pathogenesis and the contribution could be revealed by pharmacologic cyclo...
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Adis, Springer Healthcare
2025-07-01
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| Series: | Ophthalmology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40123-025-01176-1 |
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| author | Yao Ma Jia Liu Zhiqiao Liang Kangyi Yang Kun Lv Wenbo Liu Huijuan Wu |
| author_facet | Yao Ma Jia Liu Zhiqiao Liang Kangyi Yang Kun Lv Wenbo Liu Huijuan Wu |
| author_sort | Yao Ma |
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| description | Abstract Introduction The mechanism of primary angle closure disease (PACD) has been extensively investigated, while some cases remain unexplained. Hypothesizing that chronic primary ciliary block (CB) may play a role in PACD pathogenesis and the contribution could be revealed by pharmacologic cycloplegia and mydriasis, this study analyzed changes in anterior segment biometric parameters following cycloplegic intervention. Methods A total of 170 eyes of 170 Chinese subjects aged between 50 and 80 years were included: 90 in the primary angle closure suspect (PACS) group, 33 in the primary angle closure (PAC)/PAC glaucoma (PACG) group, and 47 in the normal control group. All participants underwent a comprehensive ophthalmic examination, and ultrasound biomicroscopy (UBM) was conducted in patients with PACD at the baseline. Compound tropicamide (Mydrin P, Santen, Osaka, Japan) was administered to patients for pupillary dilation. Intraocular pressure (IOP) measurement and IOLMaster were performed before and 45 min after mydriasis. Results Following dilation, PACS and PAC/PACG eyes demonstrated less significant changes in the anterior section compared to normal eyes based on △ACD-△LT (the difference in the changes of anterior chamber depth and lens thickness) (P < 0.01). Nine PACD eyes had a △ACD-△LT greater than 0.10 mm (1 PAC/PACG and 8 PACS eyes). About 8.94% of PACD eyes exhibited an elevated post-IOP. In PACS eyes, significantly higher pre-IOP (P < 0.05), shallower anterior chamber (AC, P < 0.01), more anterior lens position (P < 0.01), and narrower anterior chamber width (ACW, P < 0.05) were observed. Conclusions A minority of PACD eyes displayed obvious movement of the ciliary-lens diaphragm, suggesting that primary CB may be an infrequent occurrence in PACD eyes. Additionally, higher IOP, shallower AC, more anteriorly placed lens, and smaller ACW may facilitate the identification of IOP spikes following dilation in clinical practice. |
| format | Article |
| id | doaj-art-60ff746b97de40abb20375321bc15311 |
| institution | Kabale University |
| issn | 2193-8245 2193-6528 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Adis, Springer Healthcare |
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| series | Ophthalmology and Therapy |
| spelling | doaj-art-60ff746b97de40abb20375321bc153112025-08-20T04:01:53ZengAdis, Springer HealthcareOphthalmology and Therapy2193-82452193-65282025-07-011481985199710.1007/s40123-025-01176-1Changes in Ocular Biometry After Pharmacologic Cycloplegia and Mydriasis in Primary Angle Closure DiseaseYao Ma0Jia Liu1Zhiqiao Liang2Kangyi Yang3Kun Lv4Wenbo Liu5Huijuan Wu6Department of Ophthalmology, Peking University People’s HospitalDepartment of Ophthalmology, Peking University People’s HospitalDepartment of Ophthalmology, Peking University People’s HospitalDepartment of Ophthalmology, Peking University People’s HospitalDepartment of Ophthalmology, Peking University People’s HospitalDepartment of Ophthalmology, Peking University People’s HospitalDepartment of Ophthalmology, Peking University People’s HospitalAbstract Introduction The mechanism of primary angle closure disease (PACD) has been extensively investigated, while some cases remain unexplained. Hypothesizing that chronic primary ciliary block (CB) may play a role in PACD pathogenesis and the contribution could be revealed by pharmacologic cycloplegia and mydriasis, this study analyzed changes in anterior segment biometric parameters following cycloplegic intervention. Methods A total of 170 eyes of 170 Chinese subjects aged between 50 and 80 years were included: 90 in the primary angle closure suspect (PACS) group, 33 in the primary angle closure (PAC)/PAC glaucoma (PACG) group, and 47 in the normal control group. All participants underwent a comprehensive ophthalmic examination, and ultrasound biomicroscopy (UBM) was conducted in patients with PACD at the baseline. Compound tropicamide (Mydrin P, Santen, Osaka, Japan) was administered to patients for pupillary dilation. Intraocular pressure (IOP) measurement and IOLMaster were performed before and 45 min after mydriasis. Results Following dilation, PACS and PAC/PACG eyes demonstrated less significant changes in the anterior section compared to normal eyes based on △ACD-△LT (the difference in the changes of anterior chamber depth and lens thickness) (P < 0.01). Nine PACD eyes had a △ACD-△LT greater than 0.10 mm (1 PAC/PACG and 8 PACS eyes). About 8.94% of PACD eyes exhibited an elevated post-IOP. In PACS eyes, significantly higher pre-IOP (P < 0.05), shallower anterior chamber (AC, P < 0.01), more anterior lens position (P < 0.01), and narrower anterior chamber width (ACW, P < 0.05) were observed. Conclusions A minority of PACD eyes displayed obvious movement of the ciliary-lens diaphragm, suggesting that primary CB may be an infrequent occurrence in PACD eyes. Additionally, higher IOP, shallower AC, more anteriorly placed lens, and smaller ACW may facilitate the identification of IOP spikes following dilation in clinical practice.https://doi.org/10.1007/s40123-025-01176-1Ciliary blockPrimary angle closure glaucomaUltrasound biomicroscopyIOLMaster |
| spellingShingle | Yao Ma Jia Liu Zhiqiao Liang Kangyi Yang Kun Lv Wenbo Liu Huijuan Wu Changes in Ocular Biometry After Pharmacologic Cycloplegia and Mydriasis in Primary Angle Closure Disease Ophthalmology and Therapy Ciliary block Primary angle closure glaucoma Ultrasound biomicroscopy IOLMaster |
| title | Changes in Ocular Biometry After Pharmacologic Cycloplegia and Mydriasis in Primary Angle Closure Disease |
| title_full | Changes in Ocular Biometry After Pharmacologic Cycloplegia and Mydriasis in Primary Angle Closure Disease |
| title_fullStr | Changes in Ocular Biometry After Pharmacologic Cycloplegia and Mydriasis in Primary Angle Closure Disease |
| title_full_unstemmed | Changes in Ocular Biometry After Pharmacologic Cycloplegia and Mydriasis in Primary Angle Closure Disease |
| title_short | Changes in Ocular Biometry After Pharmacologic Cycloplegia and Mydriasis in Primary Angle Closure Disease |
| title_sort | changes in ocular biometry after pharmacologic cycloplegia and mydriasis in primary angle closure disease |
| topic | Ciliary block Primary angle closure glaucoma Ultrasound biomicroscopy IOLMaster |
| url | https://doi.org/10.1007/s40123-025-01176-1 |
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