Differentiated Thyroid Cancer Genetic Mechanisms - Focus on Vitamin D Receptor and Methylenetetrahydrofolate Reductase Gene Polymorphisms
Thyroid cancer is the most frequent endocrine cancer representing 1-1.5% of all cancers. Approximately 90% of these are differentiated thyroid carcinomas (DTC) with a favorable prognosis and cure rate. DTC has recently witnessed an increase in incidence with a relatively stable mortality rate, mostl...
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Bucharest College of Physicians
2022-03-01
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| Series: | Modern Medicine |
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| Online Access: | https://medicinamoderna.ro/wp-content/uploads/2022/03/Differentiated-Thyroid-Cancer-Genetic-Mechanisms-Focus-on-Vitamin-D-Receptor-and-Methylenetetrahydrofolate-Reductase-Gene-Polymorphisms.pdf |
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| author | Andra-Maria COCOLOS Catalina POIANA |
| author_facet | Andra-Maria COCOLOS Catalina POIANA |
| author_sort | Andra-Maria COCOLOS |
| collection | DOAJ |
| description | Thyroid cancer is the most frequent endocrine cancer representing 1-1.5% of all cancers. Approximately 90% of these are differentiated thyroid carcinomas (DTC) with a favorable prognosis and cure rate. DTC has recently witnessed an increase in incidence with a relatively stable mortality rate, mostly due to intensive screening. Despite being considered indolent and the 10-year survival rate being above 90%, local or distant recurrence can be observed in up to 20% of cases. Mutations in BRAF, RET, RAS, NTRK1, PAX8-PPARG are commonly found in DTC but studies show that genetic alterations with apparently no correlation to DTC might improve or aggravate prognosis. Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms is consider to be one of these factors, due to the fact that it exerts immunological and antineoplastic functions thought its antiproliferative and pro-differentiating actions. FokI gene polymorphism has been associated with later stage and negative prognosis in different studies. Also, polymorphisms of genes involved in folate metabolism (MTHFR, MTR, RFC1) may be incriminated in carcinogenesis, folate being an extremely important factor in DNA synthesis. Studies suggest that through correction and avoidance of incriminated neoplastic agents, thyroid cancer incidence, evolution and prognosis might improve significantly. For this to be possible we need to be aware of the molecular pathways these environmental factors use to exert their carcinogenic effects. |
| format | Article |
| id | doaj-art-60feea85d48d49a69e1be05f22136153 |
| institution | OA Journals |
| issn | 1223-0472 2360-2473 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Bucharest College of Physicians |
| record_format | Article |
| series | Modern Medicine |
| spelling | doaj-art-60feea85d48d49a69e1be05f221361532025-08-20T02:12:57ZengBucharest College of PhysiciansModern Medicine1223-04722360-24732022-03-01291713https://doi.org/10.31689/rmm.2021.29.1.7Differentiated Thyroid Cancer Genetic Mechanisms - Focus on Vitamin D Receptor and Methylenetetrahydrofolate Reductase Gene PolymorphismsAndra-Maria COCOLOS0Catalina POIANA1https://orcid.org/0000-0002-5795-3318„Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania„Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaThyroid cancer is the most frequent endocrine cancer representing 1-1.5% of all cancers. Approximately 90% of these are differentiated thyroid carcinomas (DTC) with a favorable prognosis and cure rate. DTC has recently witnessed an increase in incidence with a relatively stable mortality rate, mostly due to intensive screening. Despite being considered indolent and the 10-year survival rate being above 90%, local or distant recurrence can be observed in up to 20% of cases. Mutations in BRAF, RET, RAS, NTRK1, PAX8-PPARG are commonly found in DTC but studies show that genetic alterations with apparently no correlation to DTC might improve or aggravate prognosis. Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms is consider to be one of these factors, due to the fact that it exerts immunological and antineoplastic functions thought its antiproliferative and pro-differentiating actions. FokI gene polymorphism has been associated with later stage and negative prognosis in different studies. Also, polymorphisms of genes involved in folate metabolism (MTHFR, MTR, RFC1) may be incriminated in carcinogenesis, folate being an extremely important factor in DNA synthesis. Studies suggest that through correction and avoidance of incriminated neoplastic agents, thyroid cancer incidence, evolution and prognosis might improve significantly. For this to be possible we need to be aware of the molecular pathways these environmental factors use to exert their carcinogenic effects.https://medicinamoderna.ro/wp-content/uploads/2022/03/Differentiated-Thyroid-Cancer-Genetic-Mechanisms-Focus-on-Vitamin-D-Receptor-and-Methylenetetrahydrofolate-Reductase-Gene-Polymorphisms.pdfthyroid cancerpapillaryfollicularvitamin d |
| spellingShingle | Andra-Maria COCOLOS Catalina POIANA Differentiated Thyroid Cancer Genetic Mechanisms - Focus on Vitamin D Receptor and Methylenetetrahydrofolate Reductase Gene Polymorphisms Modern Medicine thyroid cancer papillary follicular vitamin d |
| title | Differentiated Thyroid Cancer Genetic Mechanisms - Focus on Vitamin D Receptor and Methylenetetrahydrofolate Reductase Gene Polymorphisms |
| title_full | Differentiated Thyroid Cancer Genetic Mechanisms - Focus on Vitamin D Receptor and Methylenetetrahydrofolate Reductase Gene Polymorphisms |
| title_fullStr | Differentiated Thyroid Cancer Genetic Mechanisms - Focus on Vitamin D Receptor and Methylenetetrahydrofolate Reductase Gene Polymorphisms |
| title_full_unstemmed | Differentiated Thyroid Cancer Genetic Mechanisms - Focus on Vitamin D Receptor and Methylenetetrahydrofolate Reductase Gene Polymorphisms |
| title_short | Differentiated Thyroid Cancer Genetic Mechanisms - Focus on Vitamin D Receptor and Methylenetetrahydrofolate Reductase Gene Polymorphisms |
| title_sort | differentiated thyroid cancer genetic mechanisms focus on vitamin d receptor and methylenetetrahydrofolate reductase gene polymorphisms |
| topic | thyroid cancer papillary follicular vitamin d |
| url | https://medicinamoderna.ro/wp-content/uploads/2022/03/Differentiated-Thyroid-Cancer-Genetic-Mechanisms-Focus-on-Vitamin-D-Receptor-and-Methylenetetrahydrofolate-Reductase-Gene-Polymorphisms.pdf |
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