Comparison of urine bisphenol A levels in transient tachypnea of the newborn and healthy newborns
Background. To investigate the relationship between neonatal urine bisphenol A (BPA) levels and the prevalence and prognosis of transient tachypnea of the newborn (TTN). Methods. This prospective study was conducted between January and April 2020 in the Neonatal Intensive Care Unit (NI...
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Hacettepe University Institute of Child Health
2023-02-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/5 |
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| author | Melek Büyükeren |
| author_facet | Melek Büyükeren |
| author_sort | Melek Büyükeren |
| collection | DOAJ |
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Background. To investigate the relationship between neonatal urine bisphenol A (BPA) levels and the prevalence and prognosis of transient tachypnea of the newborn (TTN).
Methods. This prospective study was conducted between January and April 2020 in the Neonatal Intensive Care Unit (NICU) of Gaziantep Cengiz Gökçek Obstetrics and Pediatric Hospital. The study group consisted of patients diagnosed with TTN and the control group was made up of healthy neonates housed together with their mothers. Urine samples were collected from the neonates within the first 6 hours postnatally.
Results. Urine BPA levels and urine BPA/creatinine levels were statistically higher in the TTN group (P < 0.005). The receiver operating characteristic (ROC) curve analysis determined the cut-off value of urine BPA for TTN to be 1.18 µg/L (95% confidence interval [CI]: 0.667-0.889, sensitivity: 78.1%, and specificity: 51.5%) and the cut-off value of urine BPA/creatinine to be 2.65 µg/g (95% CI: 0.727-0.930, sensitivity: 84.4%, and specificity: 66.7%). Furthermore, the ROC analysis indicated that the cut-off value of BPA for neonates requiring invasive respiratory support was 15.64 µg/L (95% CI: 0.568-1.000, sensitivity: 83.3%, and specificity: 96.2%) and the cut-off value for BPA/creatinine was 19.10 µg/g (95% CI: 0.777-1.000, sensitivity: 83.3%, and specificity: 84.6%) among the TTN patients.
Conclusions. BPA and BPA/creatinine values were higher in the urine of newborns diagnosed with TTN which is a fairly common cause of NICU hospitalization, in samples collected within the first 6 hours after birth, which may be a reflection of intrauterine factors.
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| format | Article |
| id | doaj-art-60f4319ca9924a899c153bfeeabbf9bd |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Hacettepe University Institute of Child Health |
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| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-60f4319ca9924a899c153bfeeabbf9bd2025-08-20T02:17:50ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212023-02-0165110.24953/turkjped.2022.304Comparison of urine bisphenol A levels in transient tachypnea of the newborn and healthy newbornsMelek Büyükeren0Division of Neonatology, Department of Pediatrics, Gaziantep Cengiz Gökçek Obstetrics and Pediatric Hospital, Gaziantep, Türkiye. Background. To investigate the relationship between neonatal urine bisphenol A (BPA) levels and the prevalence and prognosis of transient tachypnea of the newborn (TTN). Methods. This prospective study was conducted between January and April 2020 in the Neonatal Intensive Care Unit (NICU) of Gaziantep Cengiz Gökçek Obstetrics and Pediatric Hospital. The study group consisted of patients diagnosed with TTN and the control group was made up of healthy neonates housed together with their mothers. Urine samples were collected from the neonates within the first 6 hours postnatally. Results. Urine BPA levels and urine BPA/creatinine levels were statistically higher in the TTN group (P < 0.005). The receiver operating characteristic (ROC) curve analysis determined the cut-off value of urine BPA for TTN to be 1.18 µg/L (95% confidence interval [CI]: 0.667-0.889, sensitivity: 78.1%, and specificity: 51.5%) and the cut-off value of urine BPA/creatinine to be 2.65 µg/g (95% CI: 0.727-0.930, sensitivity: 84.4%, and specificity: 66.7%). Furthermore, the ROC analysis indicated that the cut-off value of BPA for neonates requiring invasive respiratory support was 15.64 µg/L (95% CI: 0.568-1.000, sensitivity: 83.3%, and specificity: 96.2%) and the cut-off value for BPA/creatinine was 19.10 µg/g (95% CI: 0.777-1.000, sensitivity: 83.3%, and specificity: 84.6%) among the TTN patients. Conclusions. BPA and BPA/creatinine values were higher in the urine of newborns diagnosed with TTN which is a fairly common cause of NICU hospitalization, in samples collected within the first 6 hours after birth, which may be a reflection of intrauterine factors. https://turkjpediatr.org/article/view/5Bisphenol Anewborntransient tachypnea of the newbornurineventilation |
| spellingShingle | Melek Büyükeren Comparison of urine bisphenol A levels in transient tachypnea of the newborn and healthy newborns The Turkish Journal of Pediatrics Bisphenol A newborn transient tachypnea of the newborn urine ventilation |
| title | Comparison of urine bisphenol A levels in transient tachypnea of the newborn and healthy newborns |
| title_full | Comparison of urine bisphenol A levels in transient tachypnea of the newborn and healthy newborns |
| title_fullStr | Comparison of urine bisphenol A levels in transient tachypnea of the newborn and healthy newborns |
| title_full_unstemmed | Comparison of urine bisphenol A levels in transient tachypnea of the newborn and healthy newborns |
| title_short | Comparison of urine bisphenol A levels in transient tachypnea of the newborn and healthy newborns |
| title_sort | comparison of urine bisphenol a levels in transient tachypnea of the newborn and healthy newborns |
| topic | Bisphenol A newborn transient tachypnea of the newborn urine ventilation |
| url | https://turkjpediatr.org/article/view/5 |
| work_keys_str_mv | AT melekbuyukeren comparisonofurinebisphenolalevelsintransienttachypneaofthenewbornandhealthynewborns |