Folate-Receptor-Targeted Gold Nanoparticles Bearing a DNA-Binding Anthraquinone
In recent years, anthraquinones have been widening their therapeutic opportunities given their numerous health benefits. The search for adequate delivery platforms to improve their pharmacokinetics leads us to propose herein folate-capped gold nanoparticles with an anthraquinone derivative attached...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Inorganics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-6740/13/3/87 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849343176639250432 |
|---|---|
| author | Ana B. Caballero Nikolas J. Hodges Michael J. Hannon |
| author_facet | Ana B. Caballero Nikolas J. Hodges Michael J. Hannon |
| author_sort | Ana B. Caballero |
| collection | DOAJ |
| description | In recent years, anthraquinones have been widening their therapeutic opportunities given their numerous health benefits. The search for adequate delivery platforms to improve their pharmacokinetics leads us to propose herein folate-capped gold nanoparticles with an anthraquinone derivative attached onto their surface. Through a straightforward, two-step procedure, we obtained stable nanoparticles that can deliver anthraquinones selectively to cells overexpressing folate receptors. The new conjugates were highly toxic against two tumour cell lines, lung carcinoma A549 and cervical carcinoma HeLa, and showed significant in vitro targeting effects for FR+ HeLa cells. We anticipate that the convenience of this synthetic procedure could enable the future development of folate-targeted conjugates bearing highly active anthraquinone-derived drugs. |
| format | Article |
| id | doaj-art-60f410909ff243bba9475a29ea92af32 |
| institution | Kabale University |
| issn | 2304-6740 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Inorganics |
| spelling | doaj-art-60f410909ff243bba9475a29ea92af322025-08-20T03:43:09ZengMDPI AGInorganics2304-67402025-03-011338710.3390/inorganics13030087Folate-Receptor-Targeted Gold Nanoparticles Bearing a DNA-Binding AnthraquinoneAna B. Caballero0Nikolas J. Hodges1Michael J. Hannon2School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UKSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UKSchool of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UKIn recent years, anthraquinones have been widening their therapeutic opportunities given their numerous health benefits. The search for adequate delivery platforms to improve their pharmacokinetics leads us to propose herein folate-capped gold nanoparticles with an anthraquinone derivative attached onto their surface. Through a straightforward, two-step procedure, we obtained stable nanoparticles that can deliver anthraquinones selectively to cells overexpressing folate receptors. The new conjugates were highly toxic against two tumour cell lines, lung carcinoma A549 and cervical carcinoma HeLa, and showed significant in vitro targeting effects for FR+ HeLa cells. We anticipate that the convenience of this synthetic procedure could enable the future development of folate-targeted conjugates bearing highly active anthraquinone-derived drugs.https://www.mdpi.com/2304-6740/13/3/87anthraquinonegold nanoparticleDNA bindingantitumorfluorescence |
| spellingShingle | Ana B. Caballero Nikolas J. Hodges Michael J. Hannon Folate-Receptor-Targeted Gold Nanoparticles Bearing a DNA-Binding Anthraquinone Inorganics anthraquinone gold nanoparticle DNA binding antitumor fluorescence |
| title | Folate-Receptor-Targeted Gold Nanoparticles Bearing a DNA-Binding Anthraquinone |
| title_full | Folate-Receptor-Targeted Gold Nanoparticles Bearing a DNA-Binding Anthraquinone |
| title_fullStr | Folate-Receptor-Targeted Gold Nanoparticles Bearing a DNA-Binding Anthraquinone |
| title_full_unstemmed | Folate-Receptor-Targeted Gold Nanoparticles Bearing a DNA-Binding Anthraquinone |
| title_short | Folate-Receptor-Targeted Gold Nanoparticles Bearing a DNA-Binding Anthraquinone |
| title_sort | folate receptor targeted gold nanoparticles bearing a dna binding anthraquinone |
| topic | anthraquinone gold nanoparticle DNA binding antitumor fluorescence |
| url | https://www.mdpi.com/2304-6740/13/3/87 |
| work_keys_str_mv | AT anabcaballero folatereceptortargetedgoldnanoparticlesbearingadnabindinganthraquinone AT nikolasjhodges folatereceptortargetedgoldnanoparticlesbearingadnabindinganthraquinone AT michaeljhannon folatereceptortargetedgoldnanoparticlesbearingadnabindinganthraquinone |