The correlation between the expression of androgen receptor splice variant-7 (AR-V7) protein with the time of occurrence of castration-resistant prostate cancer and overall survival in prostate cancer in Indonesian population
Abstract Introduction Prostate cancer follows a natural trajectory characterized by genetic alterations that transform initially hormone-sensitive cancer cells into castration-resistant prostate cancer (CRPC), which is associated with high mortality. This study endeavours to elucidate the predictive...
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SpringerOpen
2025-02-01
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| Series: | African Journal of Urology |
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| Online Access: | https://doi.org/10.1186/s12301-025-00479-w |
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| author | Indrawarman Soerohardjo Narpati Wesa Pikatan Andy Zulfiqqar Irianiwati Widodo Didik Setyo Heriyanto |
| author_facet | Indrawarman Soerohardjo Narpati Wesa Pikatan Andy Zulfiqqar Irianiwati Widodo Didik Setyo Heriyanto |
| author_sort | Indrawarman Soerohardjo |
| collection | DOAJ |
| description | Abstract Introduction Prostate cancer follows a natural trajectory characterized by genetic alterations that transform initially hormone-sensitive cancer cells into castration-resistant prostate cancer (CRPC), which is associated with high mortality. This study endeavours to elucidate the predictive role of androgen receptor splice variant 7 (AR-V7) protein expression in determining the time to CRPC onset and overall survival in prostate cancer patients. Methods This retrospective cohort study utilized paraffin-embedded tissue block samples collected from prostate cancer patients undergoing Androgen Deprivation Therapy at Dr. Sardjito General Hospital between 2016 and 2022 (n = 47). AR-V7 protein expression was assessed via immunohistochemistry. Time to CRPC and overall survival were subjected to Log- Rank analysis and Cox regression. Results Patients exhibiting AR-V7 + protein expression experienced a considerably shorter time to CRPC onset compared to those with AR-V7-expression (21.13 vs. 40.05 months; p-value = 0.020). In the assessment of overall survival, patients with AR-V7 + protein expression demonstrated significantly poorer overall survival rates in contrast to those with AR-V7-expression (17.00 vs. 22.00 months; p = 0.00). Conclusions Diminished AR-V7 + protein expression emerges as a predictive indicator for a shortened time to CRPC onset. Moreover, AR-V7 protein expression holds prognostic value in predicting overall survival among prostate cancer patients. |
| format | Article |
| id | doaj-art-60f243305f244ee891f2c570658ef4ea |
| institution | Kabale University |
| issn | 1961-9987 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | African Journal of Urology |
| spelling | doaj-art-60f243305f244ee891f2c570658ef4ea2025-02-09T12:43:40ZengSpringerOpenAfrican Journal of Urology1961-99872025-02-013111910.1186/s12301-025-00479-wThe correlation between the expression of androgen receptor splice variant-7 (AR-V7) protein with the time of occurrence of castration-resistant prostate cancer and overall survival in prostate cancer in Indonesian populationIndrawarman Soerohardjo0Narpati Wesa Pikatan1Andy Zulfiqqar2Irianiwati Widodo3Didik Setyo Heriyanto4Division of Urology, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General HospitalDivision of Urology, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General HospitalDivision of Urology, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General HospitalDepartment of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General HospitalDepartment of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General HospitalAbstract Introduction Prostate cancer follows a natural trajectory characterized by genetic alterations that transform initially hormone-sensitive cancer cells into castration-resistant prostate cancer (CRPC), which is associated with high mortality. This study endeavours to elucidate the predictive role of androgen receptor splice variant 7 (AR-V7) protein expression in determining the time to CRPC onset and overall survival in prostate cancer patients. Methods This retrospective cohort study utilized paraffin-embedded tissue block samples collected from prostate cancer patients undergoing Androgen Deprivation Therapy at Dr. Sardjito General Hospital between 2016 and 2022 (n = 47). AR-V7 protein expression was assessed via immunohistochemistry. Time to CRPC and overall survival were subjected to Log- Rank analysis and Cox regression. Results Patients exhibiting AR-V7 + protein expression experienced a considerably shorter time to CRPC onset compared to those with AR-V7-expression (21.13 vs. 40.05 months; p-value = 0.020). In the assessment of overall survival, patients with AR-V7 + protein expression demonstrated significantly poorer overall survival rates in contrast to those with AR-V7-expression (17.00 vs. 22.00 months; p = 0.00). Conclusions Diminished AR-V7 + protein expression emerges as a predictive indicator for a shortened time to CRPC onset. Moreover, AR-V7 protein expression holds prognostic value in predicting overall survival among prostate cancer patients.https://doi.org/10.1186/s12301-025-00479-wAndrogen receptorAR-V7Castration-resistant prostate cancerOverall survivalprostate neoplasms |
| spellingShingle | Indrawarman Soerohardjo Narpati Wesa Pikatan Andy Zulfiqqar Irianiwati Widodo Didik Setyo Heriyanto The correlation between the expression of androgen receptor splice variant-7 (AR-V7) protein with the time of occurrence of castration-resistant prostate cancer and overall survival in prostate cancer in Indonesian population African Journal of Urology Androgen receptor AR-V7 Castration-resistant prostate cancer Overall survival prostate neoplasms |
| title | The correlation between the expression of androgen receptor splice variant-7 (AR-V7) protein with the time of occurrence of castration-resistant prostate cancer and overall survival in prostate cancer in Indonesian population |
| title_full | The correlation between the expression of androgen receptor splice variant-7 (AR-V7) protein with the time of occurrence of castration-resistant prostate cancer and overall survival in prostate cancer in Indonesian population |
| title_fullStr | The correlation between the expression of androgen receptor splice variant-7 (AR-V7) protein with the time of occurrence of castration-resistant prostate cancer and overall survival in prostate cancer in Indonesian population |
| title_full_unstemmed | The correlation between the expression of androgen receptor splice variant-7 (AR-V7) protein with the time of occurrence of castration-resistant prostate cancer and overall survival in prostate cancer in Indonesian population |
| title_short | The correlation between the expression of androgen receptor splice variant-7 (AR-V7) protein with the time of occurrence of castration-resistant prostate cancer and overall survival in prostate cancer in Indonesian population |
| title_sort | correlation between the expression of androgen receptor splice variant 7 ar v7 protein with the time of occurrence of castration resistant prostate cancer and overall survival in prostate cancer in indonesian population |
| topic | Androgen receptor AR-V7 Castration-resistant prostate cancer Overall survival prostate neoplasms |
| url | https://doi.org/10.1186/s12301-025-00479-w |
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