Resolving tumor microenvironment heterogeneity to forecast immunotherapy response in triple-negative breast cancer through multi-scale analysis

Resolving tumor microenvironment heterogeneity to forecast immunotherapy response in triple-negative breast cancer through multi-scale analysis

BackgroundImmunotherapy has been used in the clinical management of TNBC. While BRCA1 mutations are associated with immunotherapy response, the therapeutic outcomes in TNBC patients are not promising.MethodsThis study integrated spatial, single-cell, and bulk RNA-seq data to explore the role of BRCA...

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Bibliographic Details
Main Authors: Shihao Sun, Shuang Chen, Kaiyuan Li, Ge Zhang, Nan Wang, Yijia Xu, Xinxing Wang, Jiangrui Chi, Lin Li, Yi Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
triple-negative breast cancer
BRCA1 mutation
tumor microenvironment
cancer-associated fibroblasts
immune checkpoint inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1538574/full
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