Nanoparticle-mediated SIRT1 inhibition suppresses M2 macrophage polarization and hepatocarcinogenesis in chronic hepatitis B

Nanoparticle-mediated SIRT1 inhibition suppresses M2 macrophage polarization and hepatocarcinogenesis in chronic hepatitis B

Abstract Hepatocellular carcinoma (HCC) is a major complication of chronic hepatitis B (CHB), with macrophage M2 polarization playing a critical role in shaping the tumor-promoting hepatic immune microenvironment. Sirtuin 1 (SIRT1) has been implicated in immune modulation and liver carcinogenesis. T...

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Bibliographic Details
Main Authors: He Zhang, Feng Yuan, Nan Zhao, Wenqiang Tang, Pengwei Zhao, Chunfa Liu, Shan Chen, Xiaolin Hou, Changyou Xia, Jun Chu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Nanoparticles
SIRT1 Inhibition
Macrophage polarization
Chronic hepatitis B
Hepatocellular carcinoma
Online Access:https://doi.org/10.1186/s12951-025-03447-2
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