Synthesis and In Vitro Cytotoxic Activity of N-2-(2-Furyl)-2-(chlorobenzyloxyimino)Ethyl Ciprofloxacin Derivatives
Quinolone are a class of potent broad-spectrum antibacterial drugs that target the bacterial type II DNA topoisomerases (DNA gyrase) and topoisomerase IV. In the present study, the synthesis and evaluation of cytotoxicity activity of a new series of N-pipearzinyl quinolones containing N-2-(furyl-2-y...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/842982 |
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| author | Eskandar Alipour Negar Mohammad Hosseini Fatemeh Panah Sussan K. Ardestani Maliheh Safavi Abbas Shafiee Alireza Foroumadi |
| author_facet | Eskandar Alipour Negar Mohammad Hosseini Fatemeh Panah Sussan K. Ardestani Maliheh Safavi Abbas Shafiee Alireza Foroumadi |
| author_sort | Eskandar Alipour |
| collection | DOAJ |
| description | Quinolone are a class of potent broad-spectrum antibacterial drugs that target the bacterial type II DNA topoisomerases (DNA gyrase) and topoisomerase IV. In the present study, the synthesis and evaluation of cytotoxicity activity of a new series of N-pipearzinyl quinolones containing N-2-(furyl-2-yl)-2-(chlorobenzyloxyimino) ethyl moiety (6a-c) have been studied. Preliminary screening showed that one of the new compounds, namely 7-(4-(2-(3-chlorobenzyloxyimino)-2-(furan-2-yl) ethyl) piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (6b) showed significant cytotoxic activity against human breast tumor cell lines. |
| format | Article |
| id | doaj-art-60e8f8f999d24bdb828e5191de5d884b |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-60e8f8f999d24bdb828e5191de5d884b2025-08-20T03:34:57ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-01831226123110.1155/2011/842982Synthesis and In Vitro Cytotoxic Activity of N-2-(2-Furyl)-2-(chlorobenzyloxyimino)Ethyl Ciprofloxacin DerivativesEskandar Alipour0Negar Mohammad Hosseini1Fatemeh Panah2Sussan K. Ardestani3Maliheh Safavi4Abbas Shafiee5Alireza Foroumadi6Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, IranDepartment of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, IranInstitute of Biochemistry and Biophysics, Department of Biochemistry, University of Tehran, Tehran, IranInstitute of Biochemistry and Biophysics, Department of Biochemistry, University of Tehran, Tehran, IranPharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, IranPharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Medicinal Chemistry, Faculty of Pharmacy and Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran, IranQuinolone are a class of potent broad-spectrum antibacterial drugs that target the bacterial type II DNA topoisomerases (DNA gyrase) and topoisomerase IV. In the present study, the synthesis and evaluation of cytotoxicity activity of a new series of N-pipearzinyl quinolones containing N-2-(furyl-2-yl)-2-(chlorobenzyloxyimino) ethyl moiety (6a-c) have been studied. Preliminary screening showed that one of the new compounds, namely 7-(4-(2-(3-chlorobenzyloxyimino)-2-(furan-2-yl) ethyl) piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (6b) showed significant cytotoxic activity against human breast tumor cell lines.http://dx.doi.org/10.1155/2011/842982 |
| spellingShingle | Eskandar Alipour Negar Mohammad Hosseini Fatemeh Panah Sussan K. Ardestani Maliheh Safavi Abbas Shafiee Alireza Foroumadi Synthesis and In Vitro Cytotoxic Activity of N-2-(2-Furyl)-2-(chlorobenzyloxyimino)Ethyl Ciprofloxacin Derivatives E-Journal of Chemistry |
| title | Synthesis and In Vitro Cytotoxic Activity of N-2-(2-Furyl)-2-(chlorobenzyloxyimino)Ethyl Ciprofloxacin Derivatives |
| title_full | Synthesis and In Vitro Cytotoxic Activity of N-2-(2-Furyl)-2-(chlorobenzyloxyimino)Ethyl Ciprofloxacin Derivatives |
| title_fullStr | Synthesis and In Vitro Cytotoxic Activity of N-2-(2-Furyl)-2-(chlorobenzyloxyimino)Ethyl Ciprofloxacin Derivatives |
| title_full_unstemmed | Synthesis and In Vitro Cytotoxic Activity of N-2-(2-Furyl)-2-(chlorobenzyloxyimino)Ethyl Ciprofloxacin Derivatives |
| title_short | Synthesis and In Vitro Cytotoxic Activity of N-2-(2-Furyl)-2-(chlorobenzyloxyimino)Ethyl Ciprofloxacin Derivatives |
| title_sort | synthesis and in vitro cytotoxic activity of n 2 2 furyl 2 chlorobenzyloxyimino ethyl ciprofloxacin derivatives |
| url | http://dx.doi.org/10.1155/2011/842982 |
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