IL-32 expression associated with lymph vessel invasion in intestinal type of gastric cancer
Background/Aim. Gastric cancer (GC) is fourth most frequent malignant tumor worldwide, frequently diagnosed at advanced stages with poor prognosis. The aim of study was to determine expression of interleukin (IL)-32, proinflammatory and angiogenic mediators in the tumor, peritumor and healthy tissue...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2020-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84501800158P.pdf |
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| author | Pavlović Mladen Jurišević Milena Gajović Nevena Mitrović Slobodanka Jovanović Milan Radosavljević Gordana Pantić Jelena Radovanović Dragče Arsenijević Nebojša Jovanović Ivan |
| author_facet | Pavlović Mladen Jurišević Milena Gajović Nevena Mitrović Slobodanka Jovanović Milan Radosavljević Gordana Pantić Jelena Radovanović Dragče Arsenijević Nebojša Jovanović Ivan |
| author_sort | Pavlović Mladen |
| collection | DOAJ |
| description | Background/Aim. Gastric cancer (GC) is fourth most frequent malignant tumor worldwide, frequently diagnosed at advanced stages with poor prognosis. The aim of study was to determine expression of interleukin (IL)-32, proinflammatory and angiogenic mediators in the tumor, peritumor and healthy tissue, in patients with intestinal gastric cancer and the relationship with the disease severity. Methods. The tissue samples of intestinal type of the tumor of 60 patients with GC were analyzed. Expression of IL-32, vascular endothelial growth factor (VEGF), IL-17 and CD31 were measured by immunohistochemistry. Results. IL-32, VEGF and IL-17 expression as well as microvascular density (MVD) were diminished in adjacent tumor tissues compared with the tumor ones. Further, more intense expression of IL-32 and VEGF and enhanced MVD were noticed in patients with severe (TNM stages III and IV) and more progressive GC (lymph vessel invasion). Conclusion. Higher expression of IL-32, VEGF and intense MVD in the tumor tissue of GC patients with detectable lymph vessel invasion may be considered as a sign of the tumor’s malignant progression. This indicates a protumorogenic and proangiogenic role of IL-32 in biology of intestinal type of gastric cancer. |
| format | Article |
| id | doaj-art-60e7d0baa3c8474ab1f939a2a96e268d |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-60e7d0baa3c8474ab1f939a2a96e268d2025-08-20T02:35:18ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202020-01-0177881682510.2298/VSP180727158P0042-84501800158PIL-32 expression associated with lymph vessel invasion in intestinal type of gastric cancerPavlović Mladen0Jurišević Milena1Gajović Nevena2Mitrović Slobodanka3Jovanović Milan4Radosavljević Gordana5Pantić Jelena6Radovanović Dragče7Arsenijević Nebojša8Jovanović Ivan9University of Kragujevac, Faculty of Medical Sciences, Department of Surgery, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Pharmacy, Kragujevac, Serbia + University of Kragujevac, Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Pathology, Kragujevac, SerbiaMilitary Medical Academy, Department of Abdominal Surgery, Belgrade, Serbia + University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Surgery, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research, Kragujevac, SerbiaBackground/Aim. Gastric cancer (GC) is fourth most frequent malignant tumor worldwide, frequently diagnosed at advanced stages with poor prognosis. The aim of study was to determine expression of interleukin (IL)-32, proinflammatory and angiogenic mediators in the tumor, peritumor and healthy tissue, in patients with intestinal gastric cancer and the relationship with the disease severity. Methods. The tissue samples of intestinal type of the tumor of 60 patients with GC were analyzed. Expression of IL-32, vascular endothelial growth factor (VEGF), IL-17 and CD31 were measured by immunohistochemistry. Results. IL-32, VEGF and IL-17 expression as well as microvascular density (MVD) were diminished in adjacent tumor tissues compared with the tumor ones. Further, more intense expression of IL-32 and VEGF and enhanced MVD were noticed in patients with severe (TNM stages III and IV) and more progressive GC (lymph vessel invasion). Conclusion. Higher expression of IL-32, VEGF and intense MVD in the tumor tissue of GC patients with detectable lymph vessel invasion may be considered as a sign of the tumor’s malignant progression. This indicates a protumorogenic and proangiogenic role of IL-32 in biology of intestinal type of gastric cancer.http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84501800158P.pdfstomach neoplasmsil 32 protein, humananti-allergic agentsseverity of illness indexvascular endothelial growth factorsimmunohistochemistry |
| spellingShingle | Pavlović Mladen Jurišević Milena Gajović Nevena Mitrović Slobodanka Jovanović Milan Radosavljević Gordana Pantić Jelena Radovanović Dragče Arsenijević Nebojša Jovanović Ivan IL-32 expression associated with lymph vessel invasion in intestinal type of gastric cancer Vojnosanitetski Pregled stomach neoplasms il 32 protein, human anti-allergic agents severity of illness index vascular endothelial growth factors immunohistochemistry |
| title | IL-32 expression associated with lymph vessel invasion in intestinal type of gastric cancer |
| title_full | IL-32 expression associated with lymph vessel invasion in intestinal type of gastric cancer |
| title_fullStr | IL-32 expression associated with lymph vessel invasion in intestinal type of gastric cancer |
| title_full_unstemmed | IL-32 expression associated with lymph vessel invasion in intestinal type of gastric cancer |
| title_short | IL-32 expression associated with lymph vessel invasion in intestinal type of gastric cancer |
| title_sort | il 32 expression associated with lymph vessel invasion in intestinal type of gastric cancer |
| topic | stomach neoplasms il 32 protein, human anti-allergic agents severity of illness index vascular endothelial growth factors immunohistochemistry |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84501800158P.pdf |
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