Probiotics supplementation for management of type II diabetes risk factors in adults with polycystic ovarian syndrome: a meta-analysis of randomized clinical trial
This meta-analysis of randomized controlled trials aimed to evaluate the effects of probiotic supplementation on glucose homeostasis in patients with polycystic ovary syndrome (PCOS). The meta-analysis was performed in accordance with the Cochrane Handbook guidelines and relevant the preferred repor...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022002427 |
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| author | Chengcheng Zhang Yingyue Sheng Jinchi Jiang Yuzheng Xue Leilei Yu Fengwei Tian Jianxin Zhao Hao Zhang Jian Jin Qixiao Zhai |
| author_facet | Chengcheng Zhang Yingyue Sheng Jinchi Jiang Yuzheng Xue Leilei Yu Fengwei Tian Jianxin Zhao Hao Zhang Jian Jin Qixiao Zhai |
| author_sort | Chengcheng Zhang |
| collection | DOAJ |
| description | This meta-analysis of randomized controlled trials aimed to evaluate the effects of probiotic supplementation on glucose homeostasis in patients with polycystic ovary syndrome (PCOS). The meta-analysis was performed in accordance with the Cochrane Handbook guidelines and relevant the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement criteria. Of 825 identified reports, 11 randomized clinical trials were included in the meta-analysis. An analysis of pooled extracted data revealed that supplementation with probiotics significantly decreased fasting blood glucose (FBG, n = 7; standardized mean difference (SMD) = −0.40; 95 % confidence interval (CI): −2.02, −0.02; P = 0.04) and insulin levels (n = 6; SMD = −0.57; 95 % CI: −0.89, −0.25; P = 0.0004) and the homeostatic model assessment of insulin resistance (n = 7; SMD = −0.64; 95 % CI: −0.96, −0.31; P = 0.0001) while increasing the quantitative insulin sensitivity check index (QUICKI, n = 5; SMD = 0.58; 95 % CI: 0.08, 1.09; P = 0.02) in patients with PCOS. The FBG-reducing effect decreased as the baseline body mass index (BMI) and mean age of the participants increased. Indeed, a greater number of bacterial species and a higher bacterial dose were shown to reduce QUICKI effectively. The systematic review indicated that probiotic supplementation may help to control glucose homeostasis in adults with polycystic ovarian syndrome. |
| format | Article |
| id | doaj-art-60e4f409019f4d558ccaeaf8b63a5c38 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-60e4f409019f4d558ccaeaf8b63a5c382025-02-03T11:09:30ZengTsinghua University PressFood Science and Human Wellness2213-45302023-07-0112410531063Probiotics supplementation for management of type II diabetes risk factors in adults with polycystic ovarian syndrome: a meta-analysis of randomized clinical trialChengcheng Zhang0Yingyue Sheng1Jinchi Jiang2Yuzheng Xue3Leilei Yu4Fengwei Tian5Jianxin Zhao6Hao Zhang7Jian Jin8Qixiao Zhai9State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaDepartment of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaDepartment of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China; Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, Wuxi 214122, ChinaSchool of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China; Corresponding author at: Jiangnan University, Wuxi 214122, China.State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Corresponding author at: Jiangnan University, Wuxi 214122, China.This meta-analysis of randomized controlled trials aimed to evaluate the effects of probiotic supplementation on glucose homeostasis in patients with polycystic ovary syndrome (PCOS). The meta-analysis was performed in accordance with the Cochrane Handbook guidelines and relevant the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement criteria. Of 825 identified reports, 11 randomized clinical trials were included in the meta-analysis. An analysis of pooled extracted data revealed that supplementation with probiotics significantly decreased fasting blood glucose (FBG, n = 7; standardized mean difference (SMD) = −0.40; 95 % confidence interval (CI): −2.02, −0.02; P = 0.04) and insulin levels (n = 6; SMD = −0.57; 95 % CI: −0.89, −0.25; P = 0.0004) and the homeostatic model assessment of insulin resistance (n = 7; SMD = −0.64; 95 % CI: −0.96, −0.31; P = 0.0001) while increasing the quantitative insulin sensitivity check index (QUICKI, n = 5; SMD = 0.58; 95 % CI: 0.08, 1.09; P = 0.02) in patients with PCOS. The FBG-reducing effect decreased as the baseline body mass index (BMI) and mean age of the participants increased. Indeed, a greater number of bacterial species and a higher bacterial dose were shown to reduce QUICKI effectively. The systematic review indicated that probiotic supplementation may help to control glucose homeostasis in adults with polycystic ovarian syndrome.http://www.sciencedirect.com/science/article/pii/S2213453022002427Polycystic ovary syndromeType 2 diabetesGlucose homeostasisProbioticMeta-analysisRandomized clinical trial |
| spellingShingle | Chengcheng Zhang Yingyue Sheng Jinchi Jiang Yuzheng Xue Leilei Yu Fengwei Tian Jianxin Zhao Hao Zhang Jian Jin Qixiao Zhai Probiotics supplementation for management of type II diabetes risk factors in adults with polycystic ovarian syndrome: a meta-analysis of randomized clinical trial Food Science and Human Wellness Polycystic ovary syndrome Type 2 diabetes Glucose homeostasis Probiotic Meta-analysis Randomized clinical trial |
| title | Probiotics supplementation for management of type II diabetes risk factors in adults with polycystic ovarian syndrome: a meta-analysis of randomized clinical trial |
| title_full | Probiotics supplementation for management of type II diabetes risk factors in adults with polycystic ovarian syndrome: a meta-analysis of randomized clinical trial |
| title_fullStr | Probiotics supplementation for management of type II diabetes risk factors in adults with polycystic ovarian syndrome: a meta-analysis of randomized clinical trial |
| title_full_unstemmed | Probiotics supplementation for management of type II diabetes risk factors in adults with polycystic ovarian syndrome: a meta-analysis of randomized clinical trial |
| title_short | Probiotics supplementation for management of type II diabetes risk factors in adults with polycystic ovarian syndrome: a meta-analysis of randomized clinical trial |
| title_sort | probiotics supplementation for management of type ii diabetes risk factors in adults with polycystic ovarian syndrome a meta analysis of randomized clinical trial |
| topic | Polycystic ovary syndrome Type 2 diabetes Glucose homeostasis Probiotic Meta-analysis Randomized clinical trial |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022002427 |
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