Investigation of PANoptosis pathway in age-related macular degeneration triggered by Aβ1-40

Investigation of PANoptosis pathway in age-related macular degeneration triggered by Aβ1-40

Abstract Our study aimed to identify PANoptosis in Aβ1-40-induced AMD, both in vivo and in vitro, and to determine if AIM2-PANoptosome mediates this process. We used transcriptomics to explore the signaling pathways and target genes linked to PANoptosis within a mouse model of AMD triggered by Aβ1-4...

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Bibliographic Details
Main Authors: Yuxia He, Jing Lu, Yong Du, Long Zhao, Lili Gong, Ping Wu, Qinxin Shu, Hui Peng, Xing Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
PANoptosis
Age-related macular degeneration (AMD)
Amyloid beta
Inflammation
Online Access:https://doi.org/10.1038/s41598-025-98174-x
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