Intracellular but not undetectable: A case of Francisella tularensis pericarditis
Francisella tularensis is a facultatively intracellular, gram-negative bacillus and a rare cause of infection in the United States. We report a case of a 45-year-old male who presented with ongoing fever, shortness of breath, and was found to have a pericardial effusion and pulmonic infiltrates due...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | IDCases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221425092400221X |
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| author | Nicholas P. Bergeron Cameron G. Gmehlin Haris Akhtar Kemar O. Barrett Sara S. Inglis Lawrence J. Sinak Charanjit S. Rihal Daniel C. DeSimone |
| author_facet | Nicholas P. Bergeron Cameron G. Gmehlin Haris Akhtar Kemar O. Barrett Sara S. Inglis Lawrence J. Sinak Charanjit S. Rihal Daniel C. DeSimone |
| author_sort | Nicholas P. Bergeron |
| collection | DOAJ |
| description | Francisella tularensis is a facultatively intracellular, gram-negative bacillus and a rare cause of infection in the United States. We report a case of a 45-year-old male who presented with ongoing fever, shortness of breath, and was found to have a pericardial effusion and pulmonic infiltrates due to F. tularensis. Though tularemia is classically associated with rabbits and rodents, we note the patient in our case had no clear infectious exposure. Tularemia pericarditis is extremely rare, and this will be only the second report since 1957. We highlight the possible benefits of microbial cell-free DNA next generation sequencing when infection is suspected without obvious cause to reduce the morbidity and mortality from underlying infection. |
| format | Article |
| id | doaj-art-60db8aaae5034ac4bc951798b17b1915 |
| institution | DOAJ |
| issn | 2214-2509 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj-art-60db8aaae5034ac4bc951798b17b19152025-08-20T02:57:32ZengElsevierIDCases2214-25092025-01-0139e0214510.1016/j.idcr.2024.e02145Intracellular but not undetectable: A case of Francisella tularensis pericarditisNicholas P. Bergeron0Cameron G. Gmehlin1Haris Akhtar2Kemar O. Barrett3Sara S. Inglis4Lawrence J. Sinak5Charanjit S. Rihal6Daniel C. DeSimone7Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA; Corresponding author.Department of Internal Medicine, Mayo Clinic, Rochester, MN, USADivision of Public Health, Infectious Disease, and Occupational Medicine, Mayo Clinic, Rochester, MN, USADivision of Public Health, Infectious Disease, and Occupational Medicine, Mayo Clinic, Rochester, MN, USADepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USADepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USADepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USADivision of Public Health, Infectious Disease, and Occupational Medicine, Mayo Clinic, Rochester, MN, USA; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USAFrancisella tularensis is a facultatively intracellular, gram-negative bacillus and a rare cause of infection in the United States. We report a case of a 45-year-old male who presented with ongoing fever, shortness of breath, and was found to have a pericardial effusion and pulmonic infiltrates due to F. tularensis. Though tularemia is classically associated with rabbits and rodents, we note the patient in our case had no clear infectious exposure. Tularemia pericarditis is extremely rare, and this will be only the second report since 1957. We highlight the possible benefits of microbial cell-free DNA next generation sequencing when infection is suspected without obvious cause to reduce the morbidity and mortality from underlying infection.http://www.sciencedirect.com/science/article/pii/S221425092400221XPericarditisFrancisella tularensisZoonotic diseasesMicrobial cell free DNA |
| spellingShingle | Nicholas P. Bergeron Cameron G. Gmehlin Haris Akhtar Kemar O. Barrett Sara S. Inglis Lawrence J. Sinak Charanjit S. Rihal Daniel C. DeSimone Intracellular but not undetectable: A case of Francisella tularensis pericarditis IDCases Pericarditis Francisella tularensis Zoonotic diseases Microbial cell free DNA |
| title | Intracellular but not undetectable: A case of Francisella tularensis pericarditis |
| title_full | Intracellular but not undetectable: A case of Francisella tularensis pericarditis |
| title_fullStr | Intracellular but not undetectable: A case of Francisella tularensis pericarditis |
| title_full_unstemmed | Intracellular but not undetectable: A case of Francisella tularensis pericarditis |
| title_short | Intracellular but not undetectable: A case of Francisella tularensis pericarditis |
| title_sort | intracellular but not undetectable a case of francisella tularensis pericarditis |
| topic | Pericarditis Francisella tularensis Zoonotic diseases Microbial cell free DNA |
| url | http://www.sciencedirect.com/science/article/pii/S221425092400221X |
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