Derivation of induced pluripotent stem cell TUSMi013-A from a 66-year-old Chinese Han Parkinson’s disease patient carrying VPS13C and TBP mutations
Parkinson’s Disease (PD), a prevalent neurodegenerative condition, is distinguished by its motor dysfunction. Induced pluripotent stem cells (iPSCs), derived from PD patients, constitute an exquisite investigative tool for elucidating the pathophysiology of the disease, assessing candidate therapeut...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506124003295 |
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| author | Can Cui Jian Chen Hao Shen Bei Zhang |
| author_facet | Can Cui Jian Chen Hao Shen Bei Zhang |
| author_sort | Can Cui |
| collection | DOAJ |
| description | Parkinson’s Disease (PD), a prevalent neurodegenerative condition, is distinguished by its motor dysfunction. Induced pluripotent stem cells (iPSCs), derived from PD patients, constitute an exquisite investigative tool for elucidating the pathophysiology of the disease, assessing candidate therapeutics, and probing the potential for regenerative medicine approaches. The present study was designed to establish an iPSC line, designated TUSMi013-A, from the dermal fibroblasts of a 66-year-old female afflicted with PD, harboring mutations in VPS13C and TBP. This iPSC line offers a significant resource for the dissection of PD etiology and the innovation of novel therapeutic strategies. |
| format | Article |
| id | doaj-art-60d67d84c5d4483e9b90071eb625081d |
| institution | Kabale University |
| issn | 1873-5061 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj-art-60d67d84c5d4483e9b90071eb625081d2025-02-07T04:47:24ZengElsevierStem Cell Research1873-50612025-03-0183103631Derivation of induced pluripotent stem cell TUSMi013-A from a 66-year-old Chinese Han Parkinson’s disease patient carrying VPS13C and TBP mutationsCan Cui0Jian Chen1Hao Shen2Bei Zhang3Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, ChinaFenggang County People’s Hospital, Guizhou Province 564200, ChinaDepartment of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, ChinaDepartment of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, China; Corresponding author.Parkinson’s Disease (PD), a prevalent neurodegenerative condition, is distinguished by its motor dysfunction. Induced pluripotent stem cells (iPSCs), derived from PD patients, constitute an exquisite investigative tool for elucidating the pathophysiology of the disease, assessing candidate therapeutics, and probing the potential for regenerative medicine approaches. The present study was designed to establish an iPSC line, designated TUSMi013-A, from the dermal fibroblasts of a 66-year-old female afflicted with PD, harboring mutations in VPS13C and TBP. This iPSC line offers a significant resource for the dissection of PD etiology and the innovation of novel therapeutic strategies.http://www.sciencedirect.com/science/article/pii/S1873506124003295 |
| spellingShingle | Can Cui Jian Chen Hao Shen Bei Zhang Derivation of induced pluripotent stem cell TUSMi013-A from a 66-year-old Chinese Han Parkinson’s disease patient carrying VPS13C and TBP mutations Stem Cell Research |
| title | Derivation of induced pluripotent stem cell TUSMi013-A from a 66-year-old Chinese Han Parkinson’s disease patient carrying VPS13C and TBP mutations |
| title_full | Derivation of induced pluripotent stem cell TUSMi013-A from a 66-year-old Chinese Han Parkinson’s disease patient carrying VPS13C and TBP mutations |
| title_fullStr | Derivation of induced pluripotent stem cell TUSMi013-A from a 66-year-old Chinese Han Parkinson’s disease patient carrying VPS13C and TBP mutations |
| title_full_unstemmed | Derivation of induced pluripotent stem cell TUSMi013-A from a 66-year-old Chinese Han Parkinson’s disease patient carrying VPS13C and TBP mutations |
| title_short | Derivation of induced pluripotent stem cell TUSMi013-A from a 66-year-old Chinese Han Parkinson’s disease patient carrying VPS13C and TBP mutations |
| title_sort | derivation of induced pluripotent stem cell tusmi013 a from a 66 year old chinese han parkinson s disease patient carrying vps13c and tbp mutations |
| url | http://www.sciencedirect.com/science/article/pii/S1873506124003295 |
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