Short- and Long-Term Endothelial Inflammation Have Distinct Effects and Overlap with Signatures of Cellular Senescence

Short- and Long-Term Endothelial Inflammation Have Distinct Effects and Overlap with Signatures of Cellular Senescence

This study investigates the interplay between cellular senescence and inflammation in human umbilical vein endothelial cells (HUVECs). We employed RNA sequencing to analyze gene expression changes in HUVECs subjected to replicative- or radiation-stress-induced senescence, and we compared these profi...

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Bibliographic Details
Main Authors: Barbora Belakova, José Basílio, Manuel Campos-Medina, Anna F. P. Sommer, Adrianna Gielecińska, Ulrike Resch, Johannes A. Schmid
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
senescence
acute inflammation
chronic inflammation
transcriptomics
gene set enrichment analysis
molecular signatures
Online Access:https://www.mdpi.com/2073-4409/14/11/806
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