Aminoacyl‐tRNA synthetases in medicine and disease
Abstract Aminoacyl‐tRNA synthetases (ARSs) are essential and ubiquitous ‘house‐keeping’ enzymes responsible for charging amino acids to their cognate tRNAs and providing the substrates for global protein synthesis. Recent studies have revealed a role of multiple ARSs in pathology, and their potentia...
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| Format: | Article |
| Language: | English |
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Springer Nature
2013-02-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.1002/emmm.201100626 |
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| author | Peng Yao Paul L. Fox |
| author_facet | Peng Yao Paul L. Fox |
| author_sort | Peng Yao |
| collection | DOAJ |
| description | Abstract Aminoacyl‐tRNA synthetases (ARSs) are essential and ubiquitous ‘house‐keeping’ enzymes responsible for charging amino acids to their cognate tRNAs and providing the substrates for global protein synthesis. Recent studies have revealed a role of multiple ARSs in pathology, and their potential use as pharmacological targets and therapeutic reagents. The ongoing discovery of genetic mutations in human ARSs is increasing exponentially and can be considered an important determinant of disease etiology. Several chemical compounds target bacterial, fungal and human ARSs as antibiotics or disease‐targeting medicines. Remarkably, ongoing exploration of noncanonical functions of ARSs has shown important contributions to control of angiogenesis, inflammation, tumourigenesis and other important physiopathological processes. Here, we summarize the roles of ARSs in human diseases and medicine, focusing on the most recent and exciting discoveries. |
| format | Article |
| id | doaj-art-60cf5a0962db430abbc5bb0704e5a4f3 |
| institution | OA Journals |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2013-02-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-60cf5a0962db430abbc5bb0704e5a4f32025-08-20T02:18:33ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842013-02-015333234310.1002/emmm.201100626Aminoacyl‐tRNA synthetases in medicine and diseasePeng Yao0Paul L. Fox1Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicAbstract Aminoacyl‐tRNA synthetases (ARSs) are essential and ubiquitous ‘house‐keeping’ enzymes responsible for charging amino acids to their cognate tRNAs and providing the substrates for global protein synthesis. Recent studies have revealed a role of multiple ARSs in pathology, and their potential use as pharmacological targets and therapeutic reagents. The ongoing discovery of genetic mutations in human ARSs is increasing exponentially and can be considered an important determinant of disease etiology. Several chemical compounds target bacterial, fungal and human ARSs as antibiotics or disease‐targeting medicines. Remarkably, ongoing exploration of noncanonical functions of ARSs has shown important contributions to control of angiogenesis, inflammation, tumourigenesis and other important physiopathological processes. Here, we summarize the roles of ARSs in human diseases and medicine, focusing on the most recent and exciting discoveries.https://doi.org/10.1002/emmm.201100626aminoacyl‐tRNA synthetases (ARSs)human diseasetherapeuticstRNA |
| spellingShingle | Peng Yao Paul L. Fox Aminoacyl‐tRNA synthetases in medicine and disease EMBO Molecular Medicine aminoacyl‐tRNA synthetases (ARSs) human disease therapeutics tRNA |
| title | Aminoacyl‐tRNA synthetases in medicine and disease |
| title_full | Aminoacyl‐tRNA synthetases in medicine and disease |
| title_fullStr | Aminoacyl‐tRNA synthetases in medicine and disease |
| title_full_unstemmed | Aminoacyl‐tRNA synthetases in medicine and disease |
| title_short | Aminoacyl‐tRNA synthetases in medicine and disease |
| title_sort | aminoacyl trna synthetases in medicine and disease |
| topic | aminoacyl‐tRNA synthetases (ARSs) human disease therapeutics tRNA |
| url | https://doi.org/10.1002/emmm.201100626 |
| work_keys_str_mv | AT pengyao aminoacyltrnasynthetasesinmedicineanddisease AT paullfox aminoacyltrnasynthetasesinmedicineanddisease |