Development and Validation of a Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry Method for the Determination of Asparagine in Human Serum

Development and Validation of a Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry Method for the Determination of Asparagine in Human Serum

L-Asparagine (ASN) is the catalyze substrate of L-asparaginase (ASNase), which is an important drug for acute lymphoblastic leukemia (ALL) patients. The ASN level is found to be closely associated with the effectiveness of ASNase treatment. In this study, a hydrophilic interaction liquid chromatogra...

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Main Authors: Haoyang Lu, Xiaoyun Zeng, Lihua Yu, Zhanzhang Wang, Danna Lin, Xiaojia Ni, Dewei Shang, Ming Zhang, Jinqing Hu, Shuhua Deng, Xiuqing Zhu, Yuqing Chen, Huanshan Xie, Lihua Yang, Yuguan Wen
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:International Journal of Analytical Chemistry
Online Access:http://dx.doi.org/10.1155/2020/6980392
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