Castration-Resistant Prostate Cancer: Mechanisms, Targets, and Treatment
Patients with castration-resistant prostate cancer (CRPC), who progress after docetaxel therapy, had until very recently, only a few therapeutic options. Recent advances in this field brought about new perspectives in the treatment of this disease. Molecular, basic, and translational research has gi...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/327253 |
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| _version_ | 1849410960805068800 |
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| author | Teresa Maria Santos Amaral Daniela Macedo Isabel Fernandes Luis Costa |
| author_facet | Teresa Maria Santos Amaral Daniela Macedo Isabel Fernandes Luis Costa |
| author_sort | Teresa Maria Santos Amaral |
| collection | DOAJ |
| description | Patients with castration-resistant prostate cancer (CRPC), who progress after docetaxel therapy, had until very recently, only a few therapeutic options. Recent advances in this field brought about new perspectives in the treatment of this disease. Molecular, basic, and translational research has given us a better understanding on the mechanisms of CRPC. This great investment has turned into a more rational approach to the development of new drugs. Some of the new treatments are already available to our patients outside clinical trials and may include inhibitors of androgen biosynthesis; new chemotherapy agents; bone-targeted therapy; and immunotherapy. This paper aims to review the mechanisms of prostate cancer resistance, possible therapeutic targets, as well as new options to treat CRPC. |
| format | Article |
| id | doaj-art-60c8a04646b24e9b81e0961267076e99 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-60c8a04646b24e9b81e0961267076e992025-08-20T03:34:56ZengWileyProstate Cancer2090-31112090-312X2012-01-01201210.1155/2012/327253327253Castration-Resistant Prostate Cancer: Mechanisms, Targets, and TreatmentTeresa Maria Santos Amaral0Daniela Macedo1Isabel Fernandes2Luis Costa3Oncology Division, Hospital de Santa Maria, Instituto de Medicina Molecular, 1649-039 Lisbon, PortugalOncology Division, Hospital de Santa Maria, Instituto de Medicina Molecular, 1649-039 Lisbon, PortugalOncology Division, Hospital de Santa Maria, Instituto de Medicina Molecular, 1649-039 Lisbon, PortugalOncology Division, Hospital de Santa Maria, Instituto de Medicina Molecular, 1649-039 Lisbon, PortugalPatients with castration-resistant prostate cancer (CRPC), who progress after docetaxel therapy, had until very recently, only a few therapeutic options. Recent advances in this field brought about new perspectives in the treatment of this disease. Molecular, basic, and translational research has given us a better understanding on the mechanisms of CRPC. This great investment has turned into a more rational approach to the development of new drugs. Some of the new treatments are already available to our patients outside clinical trials and may include inhibitors of androgen biosynthesis; new chemotherapy agents; bone-targeted therapy; and immunotherapy. This paper aims to review the mechanisms of prostate cancer resistance, possible therapeutic targets, as well as new options to treat CRPC.http://dx.doi.org/10.1155/2012/327253 |
| spellingShingle | Teresa Maria Santos Amaral Daniela Macedo Isabel Fernandes Luis Costa Castration-Resistant Prostate Cancer: Mechanisms, Targets, and Treatment Prostate Cancer |
| title | Castration-Resistant Prostate Cancer: Mechanisms, Targets, and Treatment |
| title_full | Castration-Resistant Prostate Cancer: Mechanisms, Targets, and Treatment |
| title_fullStr | Castration-Resistant Prostate Cancer: Mechanisms, Targets, and Treatment |
| title_full_unstemmed | Castration-Resistant Prostate Cancer: Mechanisms, Targets, and Treatment |
| title_short | Castration-Resistant Prostate Cancer: Mechanisms, Targets, and Treatment |
| title_sort | castration resistant prostate cancer mechanisms targets and treatment |
| url | http://dx.doi.org/10.1155/2012/327253 |
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