Thyroid Dysfunction and Autoantibodies Association with Hypertensive Disorders during Pregnancy
Background. Thyroid dysfunction and autoimmunity are relatively common in reproductive age and have been associated with adverse health outcomes for both mother and child, including hypertensive disorders during pregnancy. Objective. To survey the relation between thyroid dysfunction and autoimmunit...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2012/742695 |
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| author | Azin Alavi Khadijeh Adabi Sepideh Nekuie Elham Kazemi Jahromi Mehrdad Solati Alireza Sobhani Hoda Karmostaji Alireza Shahab Jahanlou |
| author_facet | Azin Alavi Khadijeh Adabi Sepideh Nekuie Elham Kazemi Jahromi Mehrdad Solati Alireza Sobhani Hoda Karmostaji Alireza Shahab Jahanlou |
| author_sort | Azin Alavi |
| collection | DOAJ |
| description | Background. Thyroid dysfunction and autoimmunity are relatively common in reproductive age and have been associated with adverse health outcomes for both mother and child, including hypertensive disorders during pregnancy. Objective. To survey the relation between thyroid dysfunction and autoimmunity and incidence and severity of pregnancy-induced hypertensive disorders. Method. In this case control study 48 hypertensive patients in 4 subgroups (gestational hypertension, mild preeclampsia, severe preeclampsia, eclampsia) and 50 normotensive ones were studied. The samples were nulliparous and matched based on age and gestational age and none of them had previous history of hypertensive or thyroid disorders and other underlying systemic diseases or took medication that might affect thyroid function. Their venous blood samples were collected using electrochemiluminescence and ELISA method and thyroid hormones and TSH and autoantibodies were measured. Results. Hypertensive patients had significant lower T3 concentration compared with normotensive ones with mean T3 values 152.5±48.93 ng/dL, 175.36±58.07 ng/dL respectively. Anti-TPO concentration is higher in control group 6.07±9.02 IU/mL compared with 2.27±2.94 IU/mL in cases. Conclusion. The severity of preeclampsia and eclampsia was not associated with thyroid function tests. The only significant value was low T3 level among pregnancy, induced hypertensive patients. |
| format | Article |
| id | doaj-art-60c5d56bd05c480eb13ff1e2d8fca330 |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-60c5d56bd05c480eb13ff1e2d8fca3302025-08-20T03:34:56ZengWileyJournal of Pregnancy2090-27272090-27352012-01-01201210.1155/2012/742695742695Thyroid Dysfunction and Autoantibodies Association with Hypertensive Disorders during PregnancyAzin Alavi0Khadijeh Adabi1Sepideh Nekuie2Elham Kazemi Jahromi3Mehrdad Solati4Alireza Sobhani5Hoda Karmostaji6Alireza Shahab Jahanlou7Obstetrics and Gynecology Department, Shariati Hospital, Infertility and Reproductive Health Research Center, Hormozgan University of Medical Sciences, Naser Boulevard, Bandarabbas 7917746345, IranObstetrics and Gynecology Department, Women Hospital, Tehran University of Medical Sciences, North Ostad Nejatolahi Avenue, Karim Khan Street, Tehran, IranObstetrics and Gynecology Department, Women Hospital, Tehran University of Medical Sciences, North Ostad Nejatolahi Avenue, Karim Khan Street, Tehran, IranPathology Department, Shariati Hospital, Hormozgan University of Medical Sciences, Naser Boulevard, Bandarabbas, IranEndocrinology Department, Shariati Hospital, Hormozgan University of Medical Sciences, Naser Boulevard, Bandarabbas 7917746345, IranPathology Department, Shariati Hospital, Hormozgan University of Medical Sciences, Naser Boulevard, Bandarabbas, IranObstetrics and Gynecology Department, Shariati Hospital, Hormozgan University of Medical Sciences, Naser Boulevard, Bandarabbas, IranHealth Education Unit, Hormozgan University of Medical Sciences, Naser Boulevard, Bandarabbas, IranBackground. Thyroid dysfunction and autoimmunity are relatively common in reproductive age and have been associated with adverse health outcomes for both mother and child, including hypertensive disorders during pregnancy. Objective. To survey the relation between thyroid dysfunction and autoimmunity and incidence and severity of pregnancy-induced hypertensive disorders. Method. In this case control study 48 hypertensive patients in 4 subgroups (gestational hypertension, mild preeclampsia, severe preeclampsia, eclampsia) and 50 normotensive ones were studied. The samples were nulliparous and matched based on age and gestational age and none of them had previous history of hypertensive or thyroid disorders and other underlying systemic diseases or took medication that might affect thyroid function. Their venous blood samples were collected using electrochemiluminescence and ELISA method and thyroid hormones and TSH and autoantibodies were measured. Results. Hypertensive patients had significant lower T3 concentration compared with normotensive ones with mean T3 values 152.5±48.93 ng/dL, 175.36±58.07 ng/dL respectively. Anti-TPO concentration is higher in control group 6.07±9.02 IU/mL compared with 2.27±2.94 IU/mL in cases. Conclusion. The severity of preeclampsia and eclampsia was not associated with thyroid function tests. The only significant value was low T3 level among pregnancy, induced hypertensive patients.http://dx.doi.org/10.1155/2012/742695 |
| spellingShingle | Azin Alavi Khadijeh Adabi Sepideh Nekuie Elham Kazemi Jahromi Mehrdad Solati Alireza Sobhani Hoda Karmostaji Alireza Shahab Jahanlou Thyroid Dysfunction and Autoantibodies Association with Hypertensive Disorders during Pregnancy Journal of Pregnancy |
| title | Thyroid Dysfunction and Autoantibodies Association with Hypertensive Disorders during Pregnancy |
| title_full | Thyroid Dysfunction and Autoantibodies Association with Hypertensive Disorders during Pregnancy |
| title_fullStr | Thyroid Dysfunction and Autoantibodies Association with Hypertensive Disorders during Pregnancy |
| title_full_unstemmed | Thyroid Dysfunction and Autoantibodies Association with Hypertensive Disorders during Pregnancy |
| title_short | Thyroid Dysfunction and Autoantibodies Association with Hypertensive Disorders during Pregnancy |
| title_sort | thyroid dysfunction and autoantibodies association with hypertensive disorders during pregnancy |
| url | http://dx.doi.org/10.1155/2012/742695 |
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