Wound repair in rabbits using autologous biomaterials combined with rosuvastatin

Autologous platelet-rich plasma (aPRP) and autologous platelet-rich fibrin (aPRF) are blood-derived biomaterials that potentially enhance wound healing. Rosuvastatin (RSV), a lipidlowering statin, exhibits pleiotropic effects that may promote tissue repair, warranting investigation into its use alon...

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Main Authors: Yuri Ferreira Vicentini, Gisele Alborghetti Nai, Rosa Maria Barilli Nogueira, Cecília Laposy Santarém
Format: Article
Language:English
Published: Universidade Federal de Goiás 2025-02-01
Series:Ciência Animal Brasileira
Online Access:https://revistas.ufg.br/vet/article/view/78752
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author Yuri Ferreira Vicentini
Gisele Alborghetti Nai
Rosa Maria Barilli Nogueira
Cecília Laposy Santarém
author_facet Yuri Ferreira Vicentini
Gisele Alborghetti Nai
Rosa Maria Barilli Nogueira
Cecília Laposy Santarém
author_sort Yuri Ferreira Vicentini
collection DOAJ
description Autologous platelet-rich plasma (aPRP) and autologous platelet-rich fibrin (aPRF) are blood-derived biomaterials that potentially enhance wound healing. Rosuvastatin (RSV), a lipidlowering statin, exhibits pleiotropic effects that may promote tissue repair, warranting investigation into its use alone or combined with biomaterials for wound healing. This study aims to evaluate the wound repair effects of aPRP and aPRF, with or without adding 1.2% rosuvastatin. Sixteen clinically healthy adult male New Zealand rabbits were randomly assigned to two groups of eight, each receiving one of the biomaterials either with or without 1.2% rosuvastatin. The biomaterials used were of autologous origin, specifically aPRP and aPRF. Surgical wounds were induced and treated with biomaterials and 1.2% rosuvastatin over 17 days. Macroscopic assessments of wound area and epithelial gap distance were conducted, supplemented by histological analysis. A significant inverse correlation was observed between wound area and epithelial thickness with the use of aPRF (r = -0.5500). No significant difference was found in epithelial thickness between treatment groups (p > 0.05). In terms of the wound area, aPRP alone (p = 0.001), aPRF alone (p = 0.021), and aPRP+RSV (p = 0.016) treatments yielded smaller wound areas compared to aPRF+RSV at 14 days post-treatment. These findings suggest that the addition of 1.2% rosuvastatin to aPRP resulting in a smaller wound area compared to aPRF, enhances wound repair.
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spelling doaj-art-60c35dc58a1542a28b03c07e5ee697bc2025-02-05T20:24:03ZengUniversidade Federal de GoiásCiência Animal Brasileira1518-27971809-68912025-02-0126Wound repair in rabbits using autologous biomaterials combined with rosuvastatinYuri Ferreira Vicentini0Gisele Alborghetti Nai1Rosa Maria Barilli Nogueira2Cecília Laposy Santarém3Universidade do Oeste Paulista (UNOESTE), Presidente Prudente, São Paulo, BrasilUniversidade do Oeste Paulista (UNOESTE), Presidente Prudente, São Paulo, BrasilUniversidade do Oeste Paulista (UNOESTE), Presidente Prudente, São Paulo, BrasilUniversidade do Oeste Paulista (UNOESTE), Presidente Prudente, São Paulo, BrasilAutologous platelet-rich plasma (aPRP) and autologous platelet-rich fibrin (aPRF) are blood-derived biomaterials that potentially enhance wound healing. Rosuvastatin (RSV), a lipidlowering statin, exhibits pleiotropic effects that may promote tissue repair, warranting investigation into its use alone or combined with biomaterials for wound healing. This study aims to evaluate the wound repair effects of aPRP and aPRF, with or without adding 1.2% rosuvastatin. Sixteen clinically healthy adult male New Zealand rabbits were randomly assigned to two groups of eight, each receiving one of the biomaterials either with or without 1.2% rosuvastatin. The biomaterials used were of autologous origin, specifically aPRP and aPRF. Surgical wounds were induced and treated with biomaterials and 1.2% rosuvastatin over 17 days. Macroscopic assessments of wound area and epithelial gap distance were conducted, supplemented by histological analysis. A significant inverse correlation was observed between wound area and epithelial thickness with the use of aPRF (r = -0.5500). No significant difference was found in epithelial thickness between treatment groups (p > 0.05). In terms of the wound area, aPRP alone (p = 0.001), aPRF alone (p = 0.021), and aPRP+RSV (p = 0.016) treatments yielded smaller wound areas compared to aPRF+RSV at 14 days post-treatment. These findings suggest that the addition of 1.2% rosuvastatin to aPRP resulting in a smaller wound area compared to aPRF, enhances wound repair. https://revistas.ufg.br/vet/article/view/78752
spellingShingle Yuri Ferreira Vicentini
Gisele Alborghetti Nai
Rosa Maria Barilli Nogueira
Cecília Laposy Santarém
Wound repair in rabbits using autologous biomaterials combined with rosuvastatin
Ciência Animal Brasileira
title Wound repair in rabbits using autologous biomaterials combined with rosuvastatin
title_full Wound repair in rabbits using autologous biomaterials combined with rosuvastatin
title_fullStr Wound repair in rabbits using autologous biomaterials combined with rosuvastatin
title_full_unstemmed Wound repair in rabbits using autologous biomaterials combined with rosuvastatin
title_short Wound repair in rabbits using autologous biomaterials combined with rosuvastatin
title_sort wound repair in rabbits using autologous biomaterials combined with rosuvastatin
url https://revistas.ufg.br/vet/article/view/78752
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