Wound repair in rabbits using autologous biomaterials combined with rosuvastatin
Autologous platelet-rich plasma (aPRP) and autologous platelet-rich fibrin (aPRF) are blood-derived biomaterials that potentially enhance wound healing. Rosuvastatin (RSV), a lipidlowering statin, exhibits pleiotropic effects that may promote tissue repair, warranting investigation into its use alon...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidade Federal de Goiás
2025-02-01
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| Series: | Ciência Animal Brasileira |
| Online Access: | https://revistas.ufg.br/vet/article/view/78752 |
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| Summary: | Autologous platelet-rich plasma (aPRP) and autologous platelet-rich fibrin (aPRF) are
blood-derived biomaterials that potentially enhance wound healing. Rosuvastatin (RSV), a lipidlowering
statin, exhibits pleiotropic effects that may promote tissue repair, warranting investigation
into its use alone or combined with biomaterials for wound healing. This study aims to evaluate the
wound repair effects of aPRP and aPRF, with or without adding 1.2% rosuvastatin. Sixteen clinically
healthy adult male New Zealand rabbits were randomly assigned to two groups of eight, each
receiving one of the biomaterials either with or without 1.2% rosuvastatin. The biomaterials used
were of autologous origin, specifically aPRP and aPRF. Surgical wounds were induced and treated
with biomaterials and 1.2% rosuvastatin over 17 days. Macroscopic assessments of wound area and
epithelial gap distance were conducted, supplemented by histological analysis. A significant inverse
correlation was observed between wound area and epithelial thickness with the use of aPRF (r =
-0.5500). No significant difference was found in epithelial thickness between treatment groups (p >
0.05). In terms of the wound area, aPRP alone (p = 0.001), aPRF alone (p = 0.021), and aPRP+RSV (p =
0.016) treatments yielded smaller wound areas compared to aPRF+RSV at 14 days post-treatment.
These findings suggest that the addition of 1.2% rosuvastatin to aPRP resulting in a smaller wound
area compared to aPRF, enhances wound repair.
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| ISSN: | 1518-2797 1809-6891 |