Integrated multiomics analysis identifies PHLDA1+ fibroblasts as prognostic biomarkers and mediators of biological functions in pancreatic cancer

Integrated multiomics analysis identifies PHLDA1+ fibroblasts as prognostic biomarkers and mediators of biological functions in pancreatic cancer

BackgroundPancreatic cancer (PC) is marked by extensive heterogeneity, posing significant challenges to effective treatment. The tumor microenvironment (TME), particularly cancer-associated fibroblasts (CAFs), plays a critical role in driving PC progression. However, the prognostic and functional co...

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Bibliographic Details
Main Authors: Rui Wang, Guan-Hua Qin, Yifei Jiang, Fu-Xiang Chen, Zi-Han Wang, Lin-Ling Ju, Lin Chen, Da Fu, En-Yu Liu, Su-Qing Zhang, Wei-Hua Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
pancreatic cancer
PHLDA1
prognostic biomarker
tumor microenvironment (TME)
spatial transcriptomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1592416/full
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