Positive predictive value and effectiveness of measles case-based surveillance in Uganda, 2012-2015.
<h4>Introduction</h4>Disease surveillance is a critical component in the control and elimination of vaccine preventable diseases. The Uganda National Expanded Program on Immunization strives to have a sensitive surveillance system within the Integrated Disease Surveillance and Response (...
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Public Library of Science (PLoS)
2017-01-01
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| author | Fred Nsubuga Immaculate Ampaire Simon Kasasa Henry Luzze Annet Kisakye |
| author_facet | Fred Nsubuga Immaculate Ampaire Simon Kasasa Henry Luzze Annet Kisakye |
| author_sort | Fred Nsubuga |
| collection | DOAJ |
| description | <h4>Introduction</h4>Disease surveillance is a critical component in the control and elimination of vaccine preventable diseases. The Uganda National Expanded Program on Immunization strives to have a sensitive surveillance system within the Integrated Disease Surveillance and Response (IDSR) framework. We analyzed measles surveillance data to determine the effectiveness of the measles case-based surveillance system and estimate its positive predictive value in order to inform policy and practice.<h4>Methods</h4>An IDSR alert was defined as ≥1 suspected measles case reported by a district in a week, through the electronic Health Management Information System. We defined an alert in the measles case-based surveillance system (CBS) as ≥1 suspected measles case with a blood sample collected for confirmation during the corresponding week in a particular district. Effectiveness of CBS was defined as having ≥80% of IDSR alerts with a blood sample collected for laboratory confirmation. Positive predictive value was defined as the proportion of measles case-patients who also had a positive measles serological result (IgM +). We reviewed case-based surveillance data with laboratory confirmation and measles surveillance data from the electronic Health Management Information System from 2012-2015.<h4>Results</h4>A total of 6,974 suspected measles case-persons were investigated by the measles case-based surveillance between 2012 and 2015. Of these, 943 (14%) were measles specific IgM positive. The median age of measles case-persons between 2013 and 2015 was 4.0 years. Between 2013 and 2015, 72% of the IDSR alerts reported in the electronic Health Management Information System, had blood samples collected for laboratory confirmation. This was however less than the WHO recommended standard of ≥80%. The PPV of CBS between 2013 and 2015 was 8.6%.<h4>Conclusion</h4>In conclusion, the effectiveness of measles case-based surveillance was sub-optimal, while the PPV showed that true measles cases have significantly reduced in Uganda. We recommended strengthening of case-based surveillance to ensure that all suspected measles cases have blood samples collected for laboratory confirmation to improve detection and ensure elimination by 2020. |
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| language | English |
| publishDate | 2017-01-01 |
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| spelling | doaj-art-60bb4e23fa85487590484f3e861c91da2025-08-20T02:03:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01129e018454910.1371/journal.pone.0184549Positive predictive value and effectiveness of measles case-based surveillance in Uganda, 2012-2015.Fred NsubugaImmaculate AmpaireSimon KasasaHenry LuzzeAnnet Kisakye<h4>Introduction</h4>Disease surveillance is a critical component in the control and elimination of vaccine preventable diseases. The Uganda National Expanded Program on Immunization strives to have a sensitive surveillance system within the Integrated Disease Surveillance and Response (IDSR) framework. We analyzed measles surveillance data to determine the effectiveness of the measles case-based surveillance system and estimate its positive predictive value in order to inform policy and practice.<h4>Methods</h4>An IDSR alert was defined as ≥1 suspected measles case reported by a district in a week, through the electronic Health Management Information System. We defined an alert in the measles case-based surveillance system (CBS) as ≥1 suspected measles case with a blood sample collected for confirmation during the corresponding week in a particular district. Effectiveness of CBS was defined as having ≥80% of IDSR alerts with a blood sample collected for laboratory confirmation. Positive predictive value was defined as the proportion of measles case-patients who also had a positive measles serological result (IgM +). We reviewed case-based surveillance data with laboratory confirmation and measles surveillance data from the electronic Health Management Information System from 2012-2015.<h4>Results</h4>A total of 6,974 suspected measles case-persons were investigated by the measles case-based surveillance between 2012 and 2015. Of these, 943 (14%) were measles specific IgM positive. The median age of measles case-persons between 2013 and 2015 was 4.0 years. Between 2013 and 2015, 72% of the IDSR alerts reported in the electronic Health Management Information System, had blood samples collected for laboratory confirmation. This was however less than the WHO recommended standard of ≥80%. The PPV of CBS between 2013 and 2015 was 8.6%.<h4>Conclusion</h4>In conclusion, the effectiveness of measles case-based surveillance was sub-optimal, while the PPV showed that true measles cases have significantly reduced in Uganda. We recommended strengthening of case-based surveillance to ensure that all suspected measles cases have blood samples collected for laboratory confirmation to improve detection and ensure elimination by 2020.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0184549&type=printable |
| spellingShingle | Fred Nsubuga Immaculate Ampaire Simon Kasasa Henry Luzze Annet Kisakye Positive predictive value and effectiveness of measles case-based surveillance in Uganda, 2012-2015. PLoS ONE |
| title | Positive predictive value and effectiveness of measles case-based surveillance in Uganda, 2012-2015. |
| title_full | Positive predictive value and effectiveness of measles case-based surveillance in Uganda, 2012-2015. |
| title_fullStr | Positive predictive value and effectiveness of measles case-based surveillance in Uganda, 2012-2015. |
| title_full_unstemmed | Positive predictive value and effectiveness of measles case-based surveillance in Uganda, 2012-2015. |
| title_short | Positive predictive value and effectiveness of measles case-based surveillance in Uganda, 2012-2015. |
| title_sort | positive predictive value and effectiveness of measles case based surveillance in uganda 2012 2015 |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0184549&type=printable |
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