Time and Concentration-dependent Cytotoxicity of Piperine on Hela Cells
Piperine, the primary alkaloid of Piper nigrum and Piper longum, is believed to have anticancer properties. Although research on cervical cancer is still in its early stages, piperine's anticancer capabilities have been established in numerous types of cancer and have been shown to target pathw...
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Universitas Andalas
2024-07-01
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| Series: | Majalah Kedokteran Andalas |
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| Online Access: | https://jurnalmka.fk.unand.ac.id/index.php/art/article/view/1470 |
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| author | Sri Oktavia Arni Amir Fatma Sri Wahyuni Hasmiwati Hasmiwati |
| author_facet | Sri Oktavia Arni Amir Fatma Sri Wahyuni Hasmiwati Hasmiwati |
| author_sort | Sri Oktavia |
| collection | DOAJ |
| description | Piperine, the primary alkaloid of Piper nigrum and Piper longum, is believed to have anticancer properties. Although research on cervical cancer is still in its early stages, piperine's anticancer capabilities have been established in numerous types of cancer and have been shown to target pathways involved in the cell cycle and apoptosis. This study aims to determine how piperine administration time and concentration affect the viability of Hela cells. The MTT method was used to conduct this study. The concentration of piperine utilized was 1,000; 500; 250; 125, and 62.5 µg/mL, and it was administered for 24 and 48 hours. The IC50 values, obtained after incubation for 24 and 48 hours, were 711.21 µg/mL and 419.75 µg/mL, respectively. We may conclude that the viability of HeLa cells is influenced by piperine in a time- and concentration-dependent manner (p<0.05). |
| format | Article |
| id | doaj-art-60b8ee3b4a72445fa46879e1f99ec9f6 |
| institution | OA Journals |
| issn | 0126-2092 2442-5230 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Universitas Andalas |
| record_format | Article |
| series | Majalah Kedokteran Andalas |
| spelling | doaj-art-60b8ee3b4a72445fa46879e1f99ec9f62025-08-20T02:13:53ZengUniversitas AndalasMajalah Kedokteran Andalas0126-20922442-52302024-07-014671174117910.25077/mka.v46.i7.p1174-1179.2023817Time and Concentration-dependent Cytotoxicity of Piperine on Hela CellsSri Oktavia0Arni Amir1Fatma Sri Wahyuni2Hasmiwati Hasmiwati3Doctoral Program, Graduate School of Biomedical Science, Faculty of Medicine, Universitas Andalas, Padang / School of Pharmaceutical Science Padang, West Sumatra, Indonesia;Department of Biology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia;Faculty of Pharmacy, Universitas Andalas, Padang, West Sumatera, Indonesia;Department of Parasitology, Faculty of Medicine, Universitas Andalas, Padang, IndonesiaPiperine, the primary alkaloid of Piper nigrum and Piper longum, is believed to have anticancer properties. Although research on cervical cancer is still in its early stages, piperine's anticancer capabilities have been established in numerous types of cancer and have been shown to target pathways involved in the cell cycle and apoptosis. This study aims to determine how piperine administration time and concentration affect the viability of Hela cells. The MTT method was used to conduct this study. The concentration of piperine utilized was 1,000; 500; 250; 125, and 62.5 µg/mL, and it was administered for 24 and 48 hours. The IC50 values, obtained after incubation for 24 and 48 hours, were 711.21 µg/mL and 419.75 µg/mL, respectively. We may conclude that the viability of HeLa cells is influenced by piperine in a time- and concentration-dependent manner (p<0.05).https://jurnalmka.fk.unand.ac.id/index.php/art/article/view/1470piperinehelacell viability |
| spellingShingle | Sri Oktavia Arni Amir Fatma Sri Wahyuni Hasmiwati Hasmiwati Time and Concentration-dependent Cytotoxicity of Piperine on Hela Cells Majalah Kedokteran Andalas piperine hela cell viability |
| title | Time and Concentration-dependent Cytotoxicity of Piperine on Hela Cells |
| title_full | Time and Concentration-dependent Cytotoxicity of Piperine on Hela Cells |
| title_fullStr | Time and Concentration-dependent Cytotoxicity of Piperine on Hela Cells |
| title_full_unstemmed | Time and Concentration-dependent Cytotoxicity of Piperine on Hela Cells |
| title_short | Time and Concentration-dependent Cytotoxicity of Piperine on Hela Cells |
| title_sort | time and concentration dependent cytotoxicity of piperine on hela cells |
| topic | piperine hela cell viability |
| url | https://jurnalmka.fk.unand.ac.id/index.php/art/article/view/1470 |
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