Inflammation in Cardiovascular Tissue Engineering: The Challenge to a Promise: A Minireview
Tissue engineering employs scaffolds, cells, and stimuli brought together in such a way as to mimic the functional architecture of the target tissue or organ. Exhilarating advances in tissue engineering and regenerative medicine allow us to envision in vitro creation or in vivo regeneration of cardi...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.4061/2011/958247 |
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| _version_ | 1850120681654583296 |
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| author | Agneta Simionescu Jason B. Schulte George Fercana Dan T. Simionescu |
| author_facet | Agneta Simionescu Jason B. Schulte George Fercana Dan T. Simionescu |
| author_sort | Agneta Simionescu |
| collection | DOAJ |
| description | Tissue engineering employs scaffolds, cells, and stimuli brought together in such a way as to mimic the functional architecture of the target tissue or organ. Exhilarating advances in tissue engineering and regenerative medicine allow us to envision in vitro creation or in vivo regeneration of cardiovascular tissues. Such accomplishments have the potential to revolutionize medicine and greatly improve our standard of life. However, enthusiasm has been hampered in recent years because of abnormal reactions at the implant-host interface, including cell proliferation, fibrosis, calcification and degeneration, as compared to the highly desired healing and remodeling. Animal and clinical studies have highlighted uncontrolled chronic inflammation as the main cause of these processes. In this minireview, we present three case studies highlighting the importance of inflammation in tissue engineering heart valves, vascular grafts, and myocardium and propose to focus on the endothelial barrier, the “final frontier” endowed with the natural potential and ability to regulate inflammatory signals. |
| format | Article |
| id | doaj-art-60adebb7474844aeb98404614c3c296f |
| institution | OA Journals |
| issn | 2042-0099 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-60adebb7474844aeb98404614c3c296f2025-08-20T02:35:18ZengWileyInternational Journal of Inflammation2042-00992011-01-01201110.4061/2011/958247958247Inflammation in Cardiovascular Tissue Engineering: The Challenge to a Promise: A MinireviewAgneta Simionescu0Jason B. Schulte1George Fercana2Dan T. Simionescu3Biocompatibility and Tissue Regeneration Laboratory, Department of Bioengineering, Clemson University, 304 Rhodes Center, Clemson, SC 29634, USABiocompatibility and Tissue Regeneration Laboratory, Department of Bioengineering, Clemson University, 304 Rhodes Center, Clemson, SC 29634, USABiocompatibility and Tissue Regeneration Laboratory, Department of Bioengineering, Clemson University, 304 Rhodes Center, Clemson, SC 29634, USABiocompatibility and Tissue Regeneration Laboratory, Department of Bioengineering, Clemson University, 304 Rhodes Center, Clemson, SC 29634, USATissue engineering employs scaffolds, cells, and stimuli brought together in such a way as to mimic the functional architecture of the target tissue or organ. Exhilarating advances in tissue engineering and regenerative medicine allow us to envision in vitro creation or in vivo regeneration of cardiovascular tissues. Such accomplishments have the potential to revolutionize medicine and greatly improve our standard of life. However, enthusiasm has been hampered in recent years because of abnormal reactions at the implant-host interface, including cell proliferation, fibrosis, calcification and degeneration, as compared to the highly desired healing and remodeling. Animal and clinical studies have highlighted uncontrolled chronic inflammation as the main cause of these processes. In this minireview, we present three case studies highlighting the importance of inflammation in tissue engineering heart valves, vascular grafts, and myocardium and propose to focus on the endothelial barrier, the “final frontier” endowed with the natural potential and ability to regulate inflammatory signals.http://dx.doi.org/10.4061/2011/958247 |
| spellingShingle | Agneta Simionescu Jason B. Schulte George Fercana Dan T. Simionescu Inflammation in Cardiovascular Tissue Engineering: The Challenge to a Promise: A Minireview International Journal of Inflammation |
| title | Inflammation in Cardiovascular Tissue Engineering: The Challenge to a Promise: A Minireview |
| title_full | Inflammation in Cardiovascular Tissue Engineering: The Challenge to a Promise: A Minireview |
| title_fullStr | Inflammation in Cardiovascular Tissue Engineering: The Challenge to a Promise: A Minireview |
| title_full_unstemmed | Inflammation in Cardiovascular Tissue Engineering: The Challenge to a Promise: A Minireview |
| title_short | Inflammation in Cardiovascular Tissue Engineering: The Challenge to a Promise: A Minireview |
| title_sort | inflammation in cardiovascular tissue engineering the challenge to a promise a minireview |
| url | http://dx.doi.org/10.4061/2011/958247 |
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