The effects of non-nutritive sweeteners on energy and macronutrients intake in adults: a grade-assessed systematic review and meta-analyses of randomized controlled trials
ObjectivesThe effect of non-nutritive sweeteners (NNSs) on long-term satiety is not well understood. This systematic review and meta-analysis were performed to investigate the effect of NNSs on long-term total energy and macronutrients intake.MethodsOnline databases including Scopus, PubMed, ISI Web...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1475962/full |
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| author | Kimia Rostampour Kimia Rostampour Kimia Rostampour Fatemeh Moghtaderi Fatemeh Moghtaderi Fatemeh Moghtaderi AmirHossein Najafi AmirHossein Najafi AmirHossein Najafi Behnaz Seyedjafari Behnaz Seyedjafari Behnaz Seyedjafari Amin Salehi-Abargouei Amin Salehi-Abargouei Amin Salehi-Abargouei |
| author_facet | Kimia Rostampour Kimia Rostampour Kimia Rostampour Fatemeh Moghtaderi Fatemeh Moghtaderi Fatemeh Moghtaderi AmirHossein Najafi AmirHossein Najafi AmirHossein Najafi Behnaz Seyedjafari Behnaz Seyedjafari Behnaz Seyedjafari Amin Salehi-Abargouei Amin Salehi-Abargouei Amin Salehi-Abargouei |
| author_sort | Kimia Rostampour |
| collection | DOAJ |
| description | ObjectivesThe effect of non-nutritive sweeteners (NNSs) on long-term satiety is not well understood. This systematic review and meta-analysis were performed to investigate the effect of NNSs on long-term total energy and macronutrients intake.MethodsOnline databases including Scopus, PubMed, ISI Web of Science, and Google Scholar were searched up to September 2024 to find relevant randomized control trials (RCTs). A random effects model was used for estimating the overall effects.ResultsThe results showed a reducing effect of NNSs consumption vs. sugar on total energy intake [total energy intake change = −175.26 kcal/day, 95% confidence interval (CI): −296.47 to −54.06, I2 = 61.19%] and carbohydrate intake [Hedges’ g = −0.35, 95% CI: −0.63 to −0.06, I2 = 58.99%]. While, NNSs intake vs. water was not associated with significant change in total energy intake [total energy intake change = 29.94 kcal/day, 95% CI: −70.37 to 130.24, I2 = 34.98%] and carbohydrate intake [Hedges’ g = 0.28, 95% CI: −0.02 to 0.58, I2 = 65.26%]. The Consumption of NNSs compared to the either sugar or water did not have a significant effect on fat intake [Hedges’ g sugar = 0.08, 95% CI: −0.10 to 0.26, I2 = 8.73%/ fat intake change water = 0.20 g/day, 95% CI: −3.48 to 3.88, I2 = 0%] and Protein intake [Hedges’ g sugar = 0.16, 95% CI: −0.11 to 0.42, I2 = 50.83%/Hedges’ g water = 0.00, 95% CI: −0.15 to 0.16, I2 = 0%].ConclusionIn summary, our findings suggest that NNSs consumption may be effective in reducing total energy and carbohydrate intake compared to sugar.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=432816, CRD42023432816. |
| format | Article |
| id | doaj-art-60acee94f7af4e25889f6432acf360fb |
| institution | OA Journals |
| issn | 2296-861X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-60acee94f7af4e25889f6432acf360fb2025-08-20T02:14:57ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-11-011110.3389/fnut.2024.14759621475962The effects of non-nutritive sweeteners on energy and macronutrients intake in adults: a grade-assessed systematic review and meta-analyses of randomized controlled trialsKimia Rostampour0Kimia Rostampour1Kimia Rostampour2Fatemeh Moghtaderi3Fatemeh Moghtaderi4Fatemeh Moghtaderi5AmirHossein Najafi6AmirHossein Najafi7AmirHossein Najafi8Behnaz Seyedjafari9Behnaz Seyedjafari10Behnaz Seyedjafari11Amin Salehi-Abargouei12Amin Salehi-Abargouei13Amin Salehi-Abargouei14Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, IranResearch Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranStudent Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, IranResearch Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranStudent Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, IranResearch Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranStudent Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, IranResearch Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranResearch Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranYazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, IranObjectivesThe effect of non-nutritive sweeteners (NNSs) on long-term satiety is not well understood. This systematic review and meta-analysis were performed to investigate the effect of NNSs on long-term total energy and macronutrients intake.MethodsOnline databases including Scopus, PubMed, ISI Web of Science, and Google Scholar were searched up to September 2024 to find relevant randomized control trials (RCTs). A random effects model was used for estimating the overall effects.ResultsThe results showed a reducing effect of NNSs consumption vs. sugar on total energy intake [total energy intake change = −175.26 kcal/day, 95% confidence interval (CI): −296.47 to −54.06, I2 = 61.19%] and carbohydrate intake [Hedges’ g = −0.35, 95% CI: −0.63 to −0.06, I2 = 58.99%]. While, NNSs intake vs. water was not associated with significant change in total energy intake [total energy intake change = 29.94 kcal/day, 95% CI: −70.37 to 130.24, I2 = 34.98%] and carbohydrate intake [Hedges’ g = 0.28, 95% CI: −0.02 to 0.58, I2 = 65.26%]. The Consumption of NNSs compared to the either sugar or water did not have a significant effect on fat intake [Hedges’ g sugar = 0.08, 95% CI: −0.10 to 0.26, I2 = 8.73%/ fat intake change water = 0.20 g/day, 95% CI: −3.48 to 3.88, I2 = 0%] and Protein intake [Hedges’ g sugar = 0.16, 95% CI: −0.11 to 0.42, I2 = 50.83%/Hedges’ g water = 0.00, 95% CI: −0.15 to 0.16, I2 = 0%].ConclusionIn summary, our findings suggest that NNSs consumption may be effective in reducing total energy and carbohydrate intake compared to sugar.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=432816, CRD42023432816.https://www.frontiersin.org/articles/10.3389/fnut.2024.1475962/fullnon-nutritive sweetenersmeta-analysisnutrients intaketotal energy intakecarbohydrate intake |
| spellingShingle | Kimia Rostampour Kimia Rostampour Kimia Rostampour Fatemeh Moghtaderi Fatemeh Moghtaderi Fatemeh Moghtaderi AmirHossein Najafi AmirHossein Najafi AmirHossein Najafi Behnaz Seyedjafari Behnaz Seyedjafari Behnaz Seyedjafari Amin Salehi-Abargouei Amin Salehi-Abargouei Amin Salehi-Abargouei The effects of non-nutritive sweeteners on energy and macronutrients intake in adults: a grade-assessed systematic review and meta-analyses of randomized controlled trials Frontiers in Nutrition non-nutritive sweeteners meta-analysis nutrients intake total energy intake carbohydrate intake |
| title | The effects of non-nutritive sweeteners on energy and macronutrients intake in adults: a grade-assessed systematic review and meta-analyses of randomized controlled trials |
| title_full | The effects of non-nutritive sweeteners on energy and macronutrients intake in adults: a grade-assessed systematic review and meta-analyses of randomized controlled trials |
| title_fullStr | The effects of non-nutritive sweeteners on energy and macronutrients intake in adults: a grade-assessed systematic review and meta-analyses of randomized controlled trials |
| title_full_unstemmed | The effects of non-nutritive sweeteners on energy and macronutrients intake in adults: a grade-assessed systematic review and meta-analyses of randomized controlled trials |
| title_short | The effects of non-nutritive sweeteners on energy and macronutrients intake in adults: a grade-assessed systematic review and meta-analyses of randomized controlled trials |
| title_sort | effects of non nutritive sweeteners on energy and macronutrients intake in adults a grade assessed systematic review and meta analyses of randomized controlled trials |
| topic | non-nutritive sweeteners meta-analysis nutrients intake total energy intake carbohydrate intake |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1475962/full |
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