Relationship between epicardial/visceral obesity and features of myocardial remodeling in patients with acquired mitral valve disease
Aim. To study the relationship between epicardial/visceral obesity and cardiac remodeling characteristics in patients with acquired mitral valve (MV) disease and indications for surgical treatment of the defect.Material and methods. The study included 49 patients hospitalized for surgery of non-infe...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2025-03-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/4301 |
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| Summary: | Aim. To study the relationship between epicardial/visceral obesity and cardiac remodeling characteristics in patients with acquired mitral valve (MV) disease and indications for surgical treatment of the defect.Material and methods. The study included 49 patients hospitalized for surgery of non-infectious acquired MV defect. Patients were divided into groups according to computed tomography as follows: group 1 — with visceral obesity (visceral adipose tissue ≥130 cm2 (n=28)), and group 2 — without visceral obesity (n=21).Results. Patients with visceral obesity had more impaired left ventricular (LV) global longitudinal strain compared to the group without visceral obesity (-15,65 [-18,8; -11,6] vs -19,4 [-21,3; -16,9]%, p=0,020). Right ventricular ejection fraction (3D echocardiography) in group 1 was lower compared to patients in group 2 as follows: median 46 [40,6; 48,9] vs 53 [45,8; 54,2]% (p=0,042). Increase in epicardial adipose tissue (EAT) volume by 1 cm3 according to multislice computed tomography was associated with left atrial increase by a B-coefficient of 0,009 (p=0,001) and LV end-systolic volume by a B-coefficient of 0,1224 (p=0,046). The visceral adipose tissue/subcutaneous adipose tissue index >0,4 is associated with an increase in the LV mass index by a B-coefficient of 44,7 (p=0,001). According to the ROC analysis, the EAT volume >115,1 cm3 is associated with arrhythmias such as atrial fibrillation (AUC=0,714 (p=0,003)).Conclusion. Visceral obesity is associated with a more pronounced structural and functional impairment of heart ventricles, while EAT volume >115,1 cm3 — with atrial fibrillation before MV defect surgery. |
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| ISSN: | 1728-8800 2619-0125 |