Advancements and Perspectives in the Bioprosthetic Heart Valve: A Comprehensive Review on Biomaterial Processing and Emerging Polymeric Materials
Heart valve disease contributes to cardiovascular disease–associated death. Bioprosthetic heart valves have emerged as a preferred option for heart valve replacement due to their superior hemodynamic performance and reduced need for lifelong anticoagulation. However, their long‐term durability is co...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.125.043061 |
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| author | Hanluo Li Shenghua Li Yalan Lei Ming Sun Chunlin Wu Xueli Wang Shiwen Xiong Qing Wang Sini Kang Song Chen Xiaoke Shang |
| author_facet | Hanluo Li Shenghua Li Yalan Lei Ming Sun Chunlin Wu Xueli Wang Shiwen Xiong Qing Wang Sini Kang Song Chen Xiaoke Shang |
| author_sort | Hanluo Li |
| collection | DOAJ |
| description | Heart valve disease contributes to cardiovascular disease–associated death. Bioprosthetic heart valves have emerged as a preferred option for heart valve replacement due to their superior hemodynamic performance and reduced need for lifelong anticoagulation. However, their long‐term durability is compromised by calcification, immunogenicity, and structural degeneration, primarily due to glutaraldehyde fixation and residual xenogeneic antigens. This review highlights recent advances in biomaterial optimization, with an emphasis on decellularization and cross‐linking strategies aimed at improving the mechanical stability and biocompatibility of bioprosthetic heart valves. The effectiveness and limitations of various decellularization agents, including nonionic, ionic, and amphoteric detergents, are critically evaluated, alongside novel cross‐linking reagents such as ribose, genipin, and polyphenols. Furthermore, the development of polymeric heart valves and nanocomposite materials is also explored as a means to address the limitations of conventional mechanical and bioprosthetic valves. Emerging strategies involving gene‐editing technologies, stem cell therapies, and tissue engineering hold considerable promise for the development of next‐generation, patient‐specific, and immunotolerant heart valve prostheses. Collectively, these innovations are driving a paradigm shift toward long‐lasting, bioactive, and regenerative heart valve replacements. |
| format | Article |
| id | doaj-art-60a69e16e3284d04835ea9099d516776 |
| institution | Kabale University |
| issn | 2047-9980 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-60a69e16e3284d04835ea9099d5167762025-08-20T07:24:44ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802025-08-01141610.1161/JAHA.125.043061Advancements and Perspectives in the Bioprosthetic Heart Valve: A Comprehensive Review on Biomaterial Processing and Emerging Polymeric MaterialsHanluo Li0Shenghua Li1Yalan Lei2Ming Sun3Chunlin Wu4Xueli Wang5Shiwen Xiong6Qing Wang7Sini Kang8Song Chen9Xiaoke Shang10National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), School of Life and Health Sciences, Hubei University of Technology Wuhan ChinaNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), School of Life and Health Sciences, Hubei University of Technology Wuhan ChinaNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), School of Life and Health Sciences, Hubei University of Technology Wuhan ChinaHubei Provincial Enterprise Technology Center, Wuhan Vickor Medical Technology Co. Wuhan ChinaHubei Provincial Enterprise Technology Center, Wuhan Vickor Medical Technology Co. Wuhan ChinaHubei Provincial Enterprise Technology Center, Wuhan Vickor Medical Technology Co. Wuhan ChinaNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), School of Life and Health Sciences, Hubei University of Technology Wuhan ChinaNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), School of Life and Health Sciences, Hubei University of Technology Wuhan ChinaNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), School of Life and Health Sciences, Hubei University of Technology Wuhan ChinaNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), School of Life and Health Sciences, Hubei University of Technology Wuhan ChinaNational “111” Center for Cellular Regulation and Molecular Pharmaceutics, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), School of Life and Health Sciences, Hubei University of Technology Wuhan ChinaHeart valve disease contributes to cardiovascular disease–associated death. Bioprosthetic heart valves have emerged as a preferred option for heart valve replacement due to their superior hemodynamic performance and reduced need for lifelong anticoagulation. However, their long‐term durability is compromised by calcification, immunogenicity, and structural degeneration, primarily due to glutaraldehyde fixation and residual xenogeneic antigens. This review highlights recent advances in biomaterial optimization, with an emphasis on decellularization and cross‐linking strategies aimed at improving the mechanical stability and biocompatibility of bioprosthetic heart valves. The effectiveness and limitations of various decellularization agents, including nonionic, ionic, and amphoteric detergents, are critically evaluated, alongside novel cross‐linking reagents such as ribose, genipin, and polyphenols. Furthermore, the development of polymeric heart valves and nanocomposite materials is also explored as a means to address the limitations of conventional mechanical and bioprosthetic valves. Emerging strategies involving gene‐editing technologies, stem cell therapies, and tissue engineering hold considerable promise for the development of next‐generation, patient‐specific, and immunotolerant heart valve prostheses. Collectively, these innovations are driving a paradigm shift toward long‐lasting, bioactive, and regenerative heart valve replacements.https://www.ahajournals.org/doi/10.1161/JAHA.125.043061biological heart valvesbiomaterialscrosslinkingdecellularizationheart valve tissue engineeringpolymeric heart valves |
| spellingShingle | Hanluo Li Shenghua Li Yalan Lei Ming Sun Chunlin Wu Xueli Wang Shiwen Xiong Qing Wang Sini Kang Song Chen Xiaoke Shang Advancements and Perspectives in the Bioprosthetic Heart Valve: A Comprehensive Review on Biomaterial Processing and Emerging Polymeric Materials Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease biological heart valves biomaterials crosslinking decellularization heart valve tissue engineering polymeric heart valves |
| title | Advancements and Perspectives in the Bioprosthetic Heart Valve: A Comprehensive Review on Biomaterial Processing and Emerging Polymeric Materials |
| title_full | Advancements and Perspectives in the Bioprosthetic Heart Valve: A Comprehensive Review on Biomaterial Processing and Emerging Polymeric Materials |
| title_fullStr | Advancements and Perspectives in the Bioprosthetic Heart Valve: A Comprehensive Review on Biomaterial Processing and Emerging Polymeric Materials |
| title_full_unstemmed | Advancements and Perspectives in the Bioprosthetic Heart Valve: A Comprehensive Review on Biomaterial Processing and Emerging Polymeric Materials |
| title_short | Advancements and Perspectives in the Bioprosthetic Heart Valve: A Comprehensive Review on Biomaterial Processing and Emerging Polymeric Materials |
| title_sort | advancements and perspectives in the bioprosthetic heart valve a comprehensive review on biomaterial processing and emerging polymeric materials |
| topic | biological heart valves biomaterials crosslinking decellularization heart valve tissue engineering polymeric heart valves |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.125.043061 |
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