Evaluation of the Expression of the Human Epithelial Receptor 2 (HER2) in Gastric Carcinoma
Objective. To evaluate the HER2 expression on gastric adenocarcinoma from a Brazilian population and also to analyze the relations between the receptor and clinical characteristics, as well as the survival status. Materials and Methods. A retrospective analysis was conducted from January of 2008 to...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2016/7951365 |
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| author | Roberto de Moraes Cordts Filho Paulo Kassab Laura Carolina Lopez Claro Mabel Tatty de Medeiros Fracassi Patrícia Colombo-Souza Daniel Kenji Fukuhara Fábio Rodrigues Thuler Wilson Rodrigues de Freitas Junior Elias Jirjoss Ilias Carlos Alberto Malheiros |
| author_facet | Roberto de Moraes Cordts Filho Paulo Kassab Laura Carolina Lopez Claro Mabel Tatty de Medeiros Fracassi Patrícia Colombo-Souza Daniel Kenji Fukuhara Fábio Rodrigues Thuler Wilson Rodrigues de Freitas Junior Elias Jirjoss Ilias Carlos Alberto Malheiros |
| author_sort | Roberto de Moraes Cordts Filho |
| collection | DOAJ |
| description | Objective. To evaluate the HER2 expression on gastric adenocarcinoma from a Brazilian population and also to analyze the relations between the receptor and clinical characteristics, as well as the survival status. Materials and Methods. A retrospective analysis was conducted from January of 2008 to July of 2012, considering only gastrectomies with curative intent. Tumors were tested for HER2 status using immunohistochemistry. The relation between HER2 status and clinical aspects, surgical findings, and survival were also analyzed. Results. 222 patients with gastric carcinoma were submitted to surgery during that period, but only 121 (54,5%) were with curative intention. The immunohistochemistry revealed that 4 patients (3,3%) were HER2-positive, 6 patients (4,9%) HER2-undetermined, and 111 patients (91,7%) HER2-negative. There was no statistical concordance between HER2 status and survival or the clinical aspects. Conclusion. The HER2 overexpression rate was very low in this Brazilian population sample and cannot be considered as a prognostic factor. |
| format | Article |
| id | doaj-art-60a1be80f124410abff7548b5dd9e971 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-60a1be80f124410abff7548b5dd9e9712025-02-03T01:06:45ZengWileyThe Scientific World Journal2356-61401537-744X2016-01-01201610.1155/2016/79513657951365Evaluation of the Expression of the Human Epithelial Receptor 2 (HER2) in Gastric CarcinomaRoberto de Moraes Cordts Filho0Paulo Kassab1Laura Carolina Lopez Claro2Mabel Tatty de Medeiros Fracassi3Patrícia Colombo-Souza4Daniel Kenji Fukuhara5Fábio Rodrigues Thuler6Wilson Rodrigues de Freitas Junior7Elias Jirjoss Ilias8Carlos Alberto Malheiros9Gastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, BrazilGastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, BrazilGastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, BrazilGastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, BrazilGastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, BrazilGastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, BrazilGastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, BrazilGastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, BrazilGastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, BrazilGastric and Obesity Surgery Division, Surgery Department, Santa Casa of São Paulo Medical School, São Paulo, SP, BrazilObjective. To evaluate the HER2 expression on gastric adenocarcinoma from a Brazilian population and also to analyze the relations between the receptor and clinical characteristics, as well as the survival status. Materials and Methods. A retrospective analysis was conducted from January of 2008 to July of 2012, considering only gastrectomies with curative intent. Tumors were tested for HER2 status using immunohistochemistry. The relation between HER2 status and clinical aspects, surgical findings, and survival were also analyzed. Results. 222 patients with gastric carcinoma were submitted to surgery during that period, but only 121 (54,5%) were with curative intention. The immunohistochemistry revealed that 4 patients (3,3%) were HER2-positive, 6 patients (4,9%) HER2-undetermined, and 111 patients (91,7%) HER2-negative. There was no statistical concordance between HER2 status and survival or the clinical aspects. Conclusion. The HER2 overexpression rate was very low in this Brazilian population sample and cannot be considered as a prognostic factor.http://dx.doi.org/10.1155/2016/7951365 |
| spellingShingle | Roberto de Moraes Cordts Filho Paulo Kassab Laura Carolina Lopez Claro Mabel Tatty de Medeiros Fracassi Patrícia Colombo-Souza Daniel Kenji Fukuhara Fábio Rodrigues Thuler Wilson Rodrigues de Freitas Junior Elias Jirjoss Ilias Carlos Alberto Malheiros Evaluation of the Expression of the Human Epithelial Receptor 2 (HER2) in Gastric Carcinoma The Scientific World Journal |
| title | Evaluation of the Expression of the Human Epithelial Receptor 2 (HER2) in Gastric Carcinoma |
| title_full | Evaluation of the Expression of the Human Epithelial Receptor 2 (HER2) in Gastric Carcinoma |
| title_fullStr | Evaluation of the Expression of the Human Epithelial Receptor 2 (HER2) in Gastric Carcinoma |
| title_full_unstemmed | Evaluation of the Expression of the Human Epithelial Receptor 2 (HER2) in Gastric Carcinoma |
| title_short | Evaluation of the Expression of the Human Epithelial Receptor 2 (HER2) in Gastric Carcinoma |
| title_sort | evaluation of the expression of the human epithelial receptor 2 her2 in gastric carcinoma |
| url | http://dx.doi.org/10.1155/2016/7951365 |
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