Preparation of Biodegradable Silk Fibroin/Alginate Blend Films for Controlled Release of Antimicrobial Drugs
Silk fibroin (SF)/alginate blend films have been prepared for controlled release of tetracycline hydrochloride, an antimicrobial model drug. The blend films were analysed by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and UV-vis spectroscopy. The functional gr...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2013/412458 |
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| author | Yaowalak Srisuwan Yodthong Baimark |
| author_facet | Yaowalak Srisuwan Yodthong Baimark |
| author_sort | Yaowalak Srisuwan |
| collection | DOAJ |
| description | Silk fibroin (SF)/alginate blend films have been prepared for controlled release of tetracycline hydrochloride, an antimicrobial model drug. The blend films were analysed by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and UV-vis spectroscopy. The functional groups of the SF/alginate blends were monitored from their FTIR spectra. The homogeneity of the blend films was observed from SEM images. The dissolution and film transparency of the blend films depended on the SF/alginate blend ratio. The in vitro drug release profile of the blend films was determined by plotting the cumulative drug release versus time. It was found that the drug release significantly decreased as the SF/alginate blend ratio increased. The results demonstrated that the SF/alginate blend films should be a useful controlled-release delivery system for water-soluble drugs. |
| format | Article |
| id | doaj-art-609f91015bbe4664a945de56c0e6224a |
| institution | Kabale University |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-609f91015bbe4664a945de56c0e6224a2025-02-03T01:24:26ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422013-01-01201310.1155/2013/412458412458Preparation of Biodegradable Silk Fibroin/Alginate Blend Films for Controlled Release of Antimicrobial DrugsYaowalak Srisuwan0Yodthong Baimark1Biodegradable Polymers Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahasarakham University, Mahasarakham 44150, ThailandBiodegradable Polymers Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahasarakham University, Mahasarakham 44150, ThailandSilk fibroin (SF)/alginate blend films have been prepared for controlled release of tetracycline hydrochloride, an antimicrobial model drug. The blend films were analysed by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and UV-vis spectroscopy. The functional groups of the SF/alginate blends were monitored from their FTIR spectra. The homogeneity of the blend films was observed from SEM images. The dissolution and film transparency of the blend films depended on the SF/alginate blend ratio. The in vitro drug release profile of the blend films was determined by plotting the cumulative drug release versus time. It was found that the drug release significantly decreased as the SF/alginate blend ratio increased. The results demonstrated that the SF/alginate blend films should be a useful controlled-release delivery system for water-soluble drugs.http://dx.doi.org/10.1155/2013/412458 |
| spellingShingle | Yaowalak Srisuwan Yodthong Baimark Preparation of Biodegradable Silk Fibroin/Alginate Blend Films for Controlled Release of Antimicrobial Drugs Advances in Materials Science and Engineering |
| title | Preparation of Biodegradable Silk Fibroin/Alginate Blend Films for Controlled Release of Antimicrobial Drugs |
| title_full | Preparation of Biodegradable Silk Fibroin/Alginate Blend Films for Controlled Release of Antimicrobial Drugs |
| title_fullStr | Preparation of Biodegradable Silk Fibroin/Alginate Blend Films for Controlled Release of Antimicrobial Drugs |
| title_full_unstemmed | Preparation of Biodegradable Silk Fibroin/Alginate Blend Films for Controlled Release of Antimicrobial Drugs |
| title_short | Preparation of Biodegradable Silk Fibroin/Alginate Blend Films for Controlled Release of Antimicrobial Drugs |
| title_sort | preparation of biodegradable silk fibroin alginate blend films for controlled release of antimicrobial drugs |
| url | http://dx.doi.org/10.1155/2013/412458 |
| work_keys_str_mv | AT yaowalaksrisuwan preparationofbiodegradablesilkfibroinalginateblendfilmsforcontrolledreleaseofantimicrobialdrugs AT yodthongbaimark preparationofbiodegradablesilkfibroinalginateblendfilmsforcontrolledreleaseofantimicrobialdrugs |