Psoriasis severity in moderate to severe psoriatic Greek patients routinely treated with systemic treatment: a cross-sectional and retrospective chart review study (CRYSTAL-Greece)
Objective To characterize the systemic treatment patterns and current state of moderate-to-severe psoriasis patients in real-world settings in Greece.Methods CRYSTAL-Greece was a multicenter, cross-sectional and retrospective chart review study assessing Psoriasis Area and Index (PASI), Dermatology...
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2024.2402344 |
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| author | Dimitrios Rigopoulos J. Katsantonis O. Neofotistou V. Chasapi E. Lazaridou A. V. Roussaki-Schulze M. Papakonstantis C. Angelakopoulos P. Rigatos P. Aronis C. Zeglinas A. Kyriakakis T. Heatta-Speicher A. Kollia K. Antachopoulou E. Papadavid |
| author_facet | Dimitrios Rigopoulos J. Katsantonis O. Neofotistou V. Chasapi E. Lazaridou A. V. Roussaki-Schulze M. Papakonstantis C. Angelakopoulos P. Rigatos P. Aronis C. Zeglinas A. Kyriakakis T. Heatta-Speicher A. Kollia K. Antachopoulou E. Papadavid |
| author_sort | Dimitrios Rigopoulos |
| collection | DOAJ |
| description | Objective To characterize the systemic treatment patterns and current state of moderate-to-severe psoriasis patients in real-world settings in Greece.Methods CRYSTAL-Greece was a multicenter, cross-sectional and retrospective chart review study assessing Psoriasis Area and Index (PASI), Dermatology Life Quality Index (DLQI) and EuroQol-5-Dimensions 5-Levels (EQ-5D-5L). Eligible patients were consented adults (18–75 years old) on continuous treatment with any approved systemic therapy regimen for ≥24 weeks.Results 280 eligible patients were enrolled between 07APR2020 and 30NOV2020. Current treatment at the study visit was biologic monotherapy in 78.2% of patients, non-biologic monotherapy in 16.1%, and conventional systemic + biologic in 5.7%. Median absolute PASI score was 1.8; of patients, 36.8%/64.6%/83.9% had PASI ≤ 1/≤3/≤5. Rates of absolute PASI > 5 were 13.7% and 28.9% in the biologic and non-biologic monotherapy subgroups, respectively. Median DLQI score was 2.0, with 18.9% of patients having DLQI > 5 (16.0% and 26.7% in the biologic and non-biologic monotherapy subgroups, respectively). The correlation between DLQI and absolute PASI was low positive (Spearman rho = 0.432; p < 0.001). Most affected EQ-5D-5L dimensions were anxiety/depression (58.6%) and pain/discomfort (28.6%).Conclusion A considerable proportion of patients still do not achieve complete or almost complete skin clearance, while one fifth of the population experience at least moderate impairment of quality of life. |
| format | Article |
| id | doaj-art-609e0f2053954caf89af4e712f9c47d3 |
| institution | Kabale University |
| issn | 0954-6634 1471-1753 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj-art-609e0f2053954caf89af4e712f9c47d32025-01-28T01:13:29ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532025-12-0136110.1080/09546634.2024.2402344Psoriasis severity in moderate to severe psoriatic Greek patients routinely treated with systemic treatment: a cross-sectional and retrospective chart review study (CRYSTAL-Greece)Dimitrios Rigopoulos0J. Katsantonis1O. Neofotistou2V. Chasapi3E. Lazaridou4A. V. Roussaki-Schulze5M. Papakonstantis6C. Angelakopoulos7P. Rigatos8P. Aronis9C. Zeglinas10A. Kyriakakis11T. Heatta-Speicher12A. Kollia13K. Antachopoulou14E. Papadavid151st Department of Dermatology and Venereology, National and Kapodistrian University of Athens, “Andreas Syggros” Hospital for Skin Diseases, Athens, GreeceDermatology Department, General Hospital “Tzaneio”, Piraeus, GreeceDermatology Department, “Konstantopouleio” General Hospital of Nea Ionia, Athens, GreeceDermatology and Venereology Department of N.H.S, “Andreas Syggros” Hospital for Skin Diseases, Athens, Greece2nd Department of Dermatology-Venereology - “Papageorgiou” General Hospital, Aristotle University School of Medicine, Thessaloniki, GreeceUniversity Clinic of Dermatology, University General Hospital of Larissa, Larissa, GreeceClinic of Dermatology, 401 General Military Hospital of Athens, Athens, GreeceFormerly at Dermatology Clinic, Athens Naval Hospital, Athens, GreeceOLYMPION Hospital-General Clinic of Patras, Patra, GreeceClinic of Dermatology, Hellenic Airforce 251 General Hospital, Athens, GreeceFormer Medical Department, AbbVie Pharmaceuticals SA, Athens, GreeceMedical Department, AbbVie Pharmaceuticals SA, Athens, GreeceGlobal Medical Affairs, AbbVie AS, Oslo, NorwayMedical Department, AbbVie Pharmaceuticals SA, Athens, GreeceGlobal Medical Affairs, AbbVie AS, Oslo, Norway2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, “Attikon” University General Hospital, Athens, GreeceObjective To characterize the systemic treatment patterns and current state of moderate-to-severe psoriasis patients in real-world settings in Greece.Methods CRYSTAL-Greece was a multicenter, cross-sectional and retrospective chart review study assessing Psoriasis Area and Index (PASI), Dermatology Life Quality Index (DLQI) and EuroQol-5-Dimensions 5-Levels (EQ-5D-5L). Eligible patients were consented adults (18–75 years old) on continuous treatment with any approved systemic therapy regimen for ≥24 weeks.Results 280 eligible patients were enrolled between 07APR2020 and 30NOV2020. Current treatment at the study visit was biologic monotherapy in 78.2% of patients, non-biologic monotherapy in 16.1%, and conventional systemic + biologic in 5.7%. Median absolute PASI score was 1.8; of patients, 36.8%/64.6%/83.9% had PASI ≤ 1/≤3/≤5. Rates of absolute PASI > 5 were 13.7% and 28.9% in the biologic and non-biologic monotherapy subgroups, respectively. Median DLQI score was 2.0, with 18.9% of patients having DLQI > 5 (16.0% and 26.7% in the biologic and non-biologic monotherapy subgroups, respectively). The correlation between DLQI and absolute PASI was low positive (Spearman rho = 0.432; p < 0.001). Most affected EQ-5D-5L dimensions were anxiety/depression (58.6%) and pain/discomfort (28.6%).Conclusion A considerable proportion of patients still do not achieve complete or almost complete skin clearance, while one fifth of the population experience at least moderate impairment of quality of life.https://www.tandfonline.com/doi/10.1080/09546634.2024.2402344Absolute PASIDLQImoderate-to-severe psoriasisreal-worldsystemic treatment |
| spellingShingle | Dimitrios Rigopoulos J. Katsantonis O. Neofotistou V. Chasapi E. Lazaridou A. V. Roussaki-Schulze M. Papakonstantis C. Angelakopoulos P. Rigatos P. Aronis C. Zeglinas A. Kyriakakis T. Heatta-Speicher A. Kollia K. Antachopoulou E. Papadavid Psoriasis severity in moderate to severe psoriatic Greek patients routinely treated with systemic treatment: a cross-sectional and retrospective chart review study (CRYSTAL-Greece) Journal of Dermatological Treatment Absolute PASI DLQI moderate-to-severe psoriasis real-world systemic treatment |
| title | Psoriasis severity in moderate to severe psoriatic Greek patients routinely treated with systemic treatment: a cross-sectional and retrospective chart review study (CRYSTAL-Greece) |
| title_full | Psoriasis severity in moderate to severe psoriatic Greek patients routinely treated with systemic treatment: a cross-sectional and retrospective chart review study (CRYSTAL-Greece) |
| title_fullStr | Psoriasis severity in moderate to severe psoriatic Greek patients routinely treated with systemic treatment: a cross-sectional and retrospective chart review study (CRYSTAL-Greece) |
| title_full_unstemmed | Psoriasis severity in moderate to severe psoriatic Greek patients routinely treated with systemic treatment: a cross-sectional and retrospective chart review study (CRYSTAL-Greece) |
| title_short | Psoriasis severity in moderate to severe psoriatic Greek patients routinely treated with systemic treatment: a cross-sectional and retrospective chart review study (CRYSTAL-Greece) |
| title_sort | psoriasis severity in moderate to severe psoriatic greek patients routinely treated with systemic treatment a cross sectional and retrospective chart review study crystal greece |
| topic | Absolute PASI DLQI moderate-to-severe psoriasis real-world systemic treatment |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2024.2402344 |
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