Quorum sensing in Porphyromonas gingivalis and oral microbial interactions: a scoping review
ObjectivePorphyromonas gingivalis, a major periodontal pathogen, interacts with other oral microbes through quorum sensing, enhancing its growth and virulence, which contributes to periodontitis. This scoping review aims to examine the role of quorum sensing in the interactions between P. gingivalis...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Oral Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2025.1573863/full |
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| author | Zelda Ziyi Zhao Wenwen Shan Lifeng Guo Chun Hung Chu Jing Zhang Jing Zhang |
| author_facet | Zelda Ziyi Zhao Wenwen Shan Lifeng Guo Chun Hung Chu Jing Zhang Jing Zhang |
| author_sort | Zelda Ziyi Zhao |
| collection | DOAJ |
| description | ObjectivePorphyromonas gingivalis, a major periodontal pathogen, interacts with other oral microbes through quorum sensing, enhancing its growth and virulence, which contributes to periodontitis. This scoping review aims to examine the role of quorum sensing in the interactions between P. gingivalis and other oral microbial species.MethodsTwo independent researchers conducted a systematic search using the keywords {[(quorum sensing) OR QS] AND [(Porphyromonas gingivalis) OR P. gingivalis]} for English publications prior to 2025 from Medline, Scopus, and Web of Science databases. They screened titles and abstracts, retrieving full texts of original studies to identify key concepts and findings regarding the quorum sensing of P. gingivalis in oral microbial ecosystems.ResultsA total of 205 publications were identified, of which 26 were included in the review. These studies demonstrated quorum sensing of P. gingivalis and other bacteria through signal molecules Autoinducer-1 and Autoinducer-2. Autoinducer-1 enhances the pathogenicity of P. gingivalis, facilitating its integration into complex oral microbial communities. Autoinducer-2 fosters cooperative or competitive relationships between P. gingivalis and other periodontal pathogens, modifying the structure of oral biofilms. Additionally, researchers are studying the use of quorum sensing inhibitors to reduce the virulence of P. gingivalis for managing periodontitis and restoring microbial balance in the oral cavity.ConclusionQuorum sensing enhances the pathogenicity of P. gingivalis in the oral environment. Through the modulation of Autoinducer-1 and Autoinducer-2, quorum sensing regulates interactions between P. gingivalis and other oral microbes. This study demonstrates the need for further research into quorum sensing-targeted interventions in periodontal therapy. |
| format | Article |
| id | doaj-art-6095ff01d3b5412189a3d4da737b3a6e |
| institution | Kabale University |
| issn | 2673-4842 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oral Health |
| spelling | doaj-art-6095ff01d3b5412189a3d4da737b3a6e2025-08-20T03:24:34ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422025-06-01610.3389/froh.2025.15738631573863Quorum sensing in Porphyromonas gingivalis and oral microbial interactions: a scoping reviewZelda Ziyi Zhao0Wenwen Shan1Lifeng Guo2Chun Hung Chu3Jing Zhang4Jing Zhang5Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaKey Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology, Anhui Medical University, Hefei, ChinaKey Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology, Anhui Medical University, Hefei, ChinaFaculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaFaculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaKey Laboratory of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology, Anhui Medical University, Hefei, ChinaObjectivePorphyromonas gingivalis, a major periodontal pathogen, interacts with other oral microbes through quorum sensing, enhancing its growth and virulence, which contributes to periodontitis. This scoping review aims to examine the role of quorum sensing in the interactions between P. gingivalis and other oral microbial species.MethodsTwo independent researchers conducted a systematic search using the keywords {[(quorum sensing) OR QS] AND [(Porphyromonas gingivalis) OR P. gingivalis]} for English publications prior to 2025 from Medline, Scopus, and Web of Science databases. They screened titles and abstracts, retrieving full texts of original studies to identify key concepts and findings regarding the quorum sensing of P. gingivalis in oral microbial ecosystems.ResultsA total of 205 publications were identified, of which 26 were included in the review. These studies demonstrated quorum sensing of P. gingivalis and other bacteria through signal molecules Autoinducer-1 and Autoinducer-2. Autoinducer-1 enhances the pathogenicity of P. gingivalis, facilitating its integration into complex oral microbial communities. Autoinducer-2 fosters cooperative or competitive relationships between P. gingivalis and other periodontal pathogens, modifying the structure of oral biofilms. Additionally, researchers are studying the use of quorum sensing inhibitors to reduce the virulence of P. gingivalis for managing periodontitis and restoring microbial balance in the oral cavity.ConclusionQuorum sensing enhances the pathogenicity of P. gingivalis in the oral environment. Through the modulation of Autoinducer-1 and Autoinducer-2, quorum sensing regulates interactions between P. gingivalis and other oral microbes. This study demonstrates the need for further research into quorum sensing-targeted interventions in periodontal therapy.https://www.frontiersin.org/articles/10.3389/froh.2025.1573863/fullquorum sensingmicrobial interactionPorphyromonas gingivalisbiofilmsperiodontal disease |
| spellingShingle | Zelda Ziyi Zhao Wenwen Shan Lifeng Guo Chun Hung Chu Jing Zhang Jing Zhang Quorum sensing in Porphyromonas gingivalis and oral microbial interactions: a scoping review Frontiers in Oral Health quorum sensing microbial interaction Porphyromonas gingivalis biofilms periodontal disease |
| title | Quorum sensing in Porphyromonas gingivalis and oral microbial interactions: a scoping review |
| title_full | Quorum sensing in Porphyromonas gingivalis and oral microbial interactions: a scoping review |
| title_fullStr | Quorum sensing in Porphyromonas gingivalis and oral microbial interactions: a scoping review |
| title_full_unstemmed | Quorum sensing in Porphyromonas gingivalis and oral microbial interactions: a scoping review |
| title_short | Quorum sensing in Porphyromonas gingivalis and oral microbial interactions: a scoping review |
| title_sort | quorum sensing in porphyromonas gingivalis and oral microbial interactions a scoping review |
| topic | quorum sensing microbial interaction Porphyromonas gingivalis biofilms periodontal disease |
| url | https://www.frontiersin.org/articles/10.3389/froh.2025.1573863/full |
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