PD-L1 on Circulating Tumor Cells Indicates Poor Prognosis in Breast Cancer
Background: In breast cancer, research concerning programmed death-ligand 1 (PD-L1) on circulating tumor cells (CTCs) is limited. Besides, the best cell type for determining the prognostic and predictive values of PD-L1 has not been established. This study investigated associations between PD-L1 on...
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IMR Press
2022-11-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/49/11/10.31083/j.ceog4911249 |
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| author | Xue-fei Wang Guo-chao Zhang Sha-fei Wu Jia-xin Li Qiang Sun |
| author_facet | Xue-fei Wang Guo-chao Zhang Sha-fei Wu Jia-xin Li Qiang Sun |
| author_sort | Xue-fei Wang |
| collection | DOAJ |
| description | Background: In breast cancer, research concerning programmed death-ligand 1 (PD-L1) on circulating tumor cells (CTCs) is limited. Besides, the best cell type for determining the prognostic and predictive values of PD-L1 has not been established. This study investigated associations between PD-L1 on tumor cells (TCs), CTCs, and tumor-infiltrating immune cells (TIICs), respectively, and prognosis and clinicopathological features in breast cancer. Methods: Twenty patients with breast cancer were recruited; one was excluded for confirmed lymphoma. The PD-L1 on TCs and TIICs was determined via immunohistochemistry; PD-L1 mRNA expression on CTCs was analyzed. The chi-squared test and Kaplan-Meier and Cox proportional hazards model analyses were applied. Results: The median follow-up time was 60 months. Of the 19 patients, 14 had >1 CTC/10 mL peripheral blood. Among these, each had ≥1 CTC showing PD-L1. At baseline, there was no difference between groups with or without metastasis regarding CTCs and PD-L1 expression. Patients with high PD-L1 levels on CTCs had poor overall survival (p = 0.034). In the multivariate analysis, PD-L1 levels on CTCs and T stage were independent prognostic factors (p = 0.029, 0.010, respectively). Conclusions: High levels of PD-L1 on CTCs may prognose shorter overall survival in breast cancer. |
| format | Article |
| id | doaj-art-609316f3bee84760bbdcf2a65e8fd062 |
| institution | Kabale University |
| issn | 0390-6663 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-609316f3bee84760bbdcf2a65e8fd0622025-08-20T03:48:31ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632022-11-01491124910.31083/j.ceog4911249S0390-6663(22)01887-5PD-L1 on Circulating Tumor Cells Indicates Poor Prognosis in Breast CancerXue-fei Wang0Guo-chao Zhang1Sha-fei Wu2Jia-xin Li3Qiang Sun4Breast Surgery Department, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College and Hospital, 100730 Beijing, ChinaDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, 100021 Beijing, ChinaMolecular Pathology Research Center, Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 100730 Beijing, ChinaBreast Surgery Department, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College and Hospital, 100730 Beijing, ChinaBreast Surgery Department, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College and Hospital, 100730 Beijing, ChinaBackground: In breast cancer, research concerning programmed death-ligand 1 (PD-L1) on circulating tumor cells (CTCs) is limited. Besides, the best cell type for determining the prognostic and predictive values of PD-L1 has not been established. This study investigated associations between PD-L1 on tumor cells (TCs), CTCs, and tumor-infiltrating immune cells (TIICs), respectively, and prognosis and clinicopathological features in breast cancer. Methods: Twenty patients with breast cancer were recruited; one was excluded for confirmed lymphoma. The PD-L1 on TCs and TIICs was determined via immunohistochemistry; PD-L1 mRNA expression on CTCs was analyzed. The chi-squared test and Kaplan-Meier and Cox proportional hazards model analyses were applied. Results: The median follow-up time was 60 months. Of the 19 patients, 14 had >1 CTC/10 mL peripheral blood. Among these, each had ≥1 CTC showing PD-L1. At baseline, there was no difference between groups with or without metastasis regarding CTCs and PD-L1 expression. Patients with high PD-L1 levels on CTCs had poor overall survival (p = 0.034). In the multivariate analysis, PD-L1 levels on CTCs and T stage were independent prognostic factors (p = 0.029, 0.010, respectively). Conclusions: High levels of PD-L1 on CTCs may prognose shorter overall survival in breast cancer.https://www.imrpress.com/journal/CEOG/49/11/10.31083/j.ceog4911249breast cancerprogrammed-cell death ligand-1 (pd-l1)overall survivalcirculating tumor cell |
| spellingShingle | Xue-fei Wang Guo-chao Zhang Sha-fei Wu Jia-xin Li Qiang Sun PD-L1 on Circulating Tumor Cells Indicates Poor Prognosis in Breast Cancer Clinical and Experimental Obstetrics & Gynecology breast cancer programmed-cell death ligand-1 (pd-l1) overall survival circulating tumor cell |
| title | PD-L1 on Circulating Tumor Cells Indicates Poor Prognosis in Breast Cancer |
| title_full | PD-L1 on Circulating Tumor Cells Indicates Poor Prognosis in Breast Cancer |
| title_fullStr | PD-L1 on Circulating Tumor Cells Indicates Poor Prognosis in Breast Cancer |
| title_full_unstemmed | PD-L1 on Circulating Tumor Cells Indicates Poor Prognosis in Breast Cancer |
| title_short | PD-L1 on Circulating Tumor Cells Indicates Poor Prognosis in Breast Cancer |
| title_sort | pd l1 on circulating tumor cells indicates poor prognosis in breast cancer |
| topic | breast cancer programmed-cell death ligand-1 (pd-l1) overall survival circulating tumor cell |
| url | https://www.imrpress.com/journal/CEOG/49/11/10.31083/j.ceog4911249 |
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