Clinical Utility of Neutrophil CD64 to Detect Extrapulmonary Tuberculosis in Three Patients with Rheumatoid Arthritis Undergoing Treatment with Biologics
Biologics play a key role in the treatment of rheumatoid arthritis (RA), while RA-related serious infection remains an unsettled clinical problem. Detection of tuberculosis (TB) is challenging due to the difficulty in distinguishing symptoms such as fever and elevation of inflammatory markers from o...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2018/2856546 |
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| _version_ | 1832552567572267008 |
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| author | Shinichi Nogi Yoshiyuki Arinuma Akiko Komiya Atsushi Hashimoto Toshihiro Matsui Shigeto Tohma |
| author_facet | Shinichi Nogi Yoshiyuki Arinuma Akiko Komiya Atsushi Hashimoto Toshihiro Matsui Shigeto Tohma |
| author_sort | Shinichi Nogi |
| collection | DOAJ |
| description | Biologics play a key role in the treatment of rheumatoid arthritis (RA), while RA-related serious infection remains an unsettled clinical problem. Detection of tuberculosis (TB) is challenging due to the difficulty in distinguishing symptoms such as fever and elevation of inflammatory markers from other infections or a disease flare of RA. The expression of the CD64 molecule on neutrophils (neutrophil CD64) was upregulated by various infections including TB. However, it was not affected by disease activity of RA or by any therapy against RA. The present article reports three cases of extrapulmonary TB which occurred in patients with RA undergoing treatment with biologics. The marked increase in the levels of neutrophil CD64 may provide important insight into the diagnosis of TB. |
| format | Article |
| id | doaj-art-6091e856ab0a49018a0de3bafe9c675a |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-6091e856ab0a49018a0de3bafe9c675a2025-02-03T05:58:20ZengWileyCase Reports in Rheumatology2090-68892090-68972018-01-01201810.1155/2018/28565462856546Clinical Utility of Neutrophil CD64 to Detect Extrapulmonary Tuberculosis in Three Patients with Rheumatoid Arthritis Undergoing Treatment with BiologicsShinichi Nogi0Yoshiyuki Arinuma1Akiko Komiya2Atsushi Hashimoto3Toshihiro Matsui4Shigeto Tohma5Department of Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Kanagawa, JapanDepartment of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Kanagawa, JapanDepartment of Clinical Laboratory, National Hospital Organization Sagamihara National Hospital, Sagamihara, Kanagawa, JapanDepartment of Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Kanagawa, JapanDepartment of Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Kanagawa, JapanPresident, National Hospital Organization Tokyo National Hospital, Tokyo, JapanBiologics play a key role in the treatment of rheumatoid arthritis (RA), while RA-related serious infection remains an unsettled clinical problem. Detection of tuberculosis (TB) is challenging due to the difficulty in distinguishing symptoms such as fever and elevation of inflammatory markers from other infections or a disease flare of RA. The expression of the CD64 molecule on neutrophils (neutrophil CD64) was upregulated by various infections including TB. However, it was not affected by disease activity of RA or by any therapy against RA. The present article reports three cases of extrapulmonary TB which occurred in patients with RA undergoing treatment with biologics. The marked increase in the levels of neutrophil CD64 may provide important insight into the diagnosis of TB.http://dx.doi.org/10.1155/2018/2856546 |
| spellingShingle | Shinichi Nogi Yoshiyuki Arinuma Akiko Komiya Atsushi Hashimoto Toshihiro Matsui Shigeto Tohma Clinical Utility of Neutrophil CD64 to Detect Extrapulmonary Tuberculosis in Three Patients with Rheumatoid Arthritis Undergoing Treatment with Biologics Case Reports in Rheumatology |
| title | Clinical Utility of Neutrophil CD64 to Detect Extrapulmonary Tuberculosis in Three Patients with Rheumatoid Arthritis Undergoing Treatment with Biologics |
| title_full | Clinical Utility of Neutrophil CD64 to Detect Extrapulmonary Tuberculosis in Three Patients with Rheumatoid Arthritis Undergoing Treatment with Biologics |
| title_fullStr | Clinical Utility of Neutrophil CD64 to Detect Extrapulmonary Tuberculosis in Three Patients with Rheumatoid Arthritis Undergoing Treatment with Biologics |
| title_full_unstemmed | Clinical Utility of Neutrophil CD64 to Detect Extrapulmonary Tuberculosis in Three Patients with Rheumatoid Arthritis Undergoing Treatment with Biologics |
| title_short | Clinical Utility of Neutrophil CD64 to Detect Extrapulmonary Tuberculosis in Three Patients with Rheumatoid Arthritis Undergoing Treatment with Biologics |
| title_sort | clinical utility of neutrophil cd64 to detect extrapulmonary tuberculosis in three patients with rheumatoid arthritis undergoing treatment with biologics |
| url | http://dx.doi.org/10.1155/2018/2856546 |
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