Antimicrobial Peptides from Amphibian Innate Immune System as Potent Antidiabetic Agents: A Literature Review and Bioinformatics Analysis
Antimicrobial peptides, as an important member of the innate immune system, have various biological activities in addition to antimicrobial activity. There are some AMPs with antidiabetic activity, especially those isolated from amphibians. These peptides can induce insulin release via different mec...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/2894722 |
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| author | Hossein Soltaninejad Hadi Zare-Zardini Mahtab Ordooei Yaser Ghelmani Akram Ghadiri-Anari Sanaz Mojahedi Amir Ali Hamidieh |
| author_facet | Hossein Soltaninejad Hadi Zare-Zardini Mahtab Ordooei Yaser Ghelmani Akram Ghadiri-Anari Sanaz Mojahedi Amir Ali Hamidieh |
| author_sort | Hossein Soltaninejad |
| collection | DOAJ |
| description | Antimicrobial peptides, as an important member of the innate immune system, have various biological activities in addition to antimicrobial activity. There are some AMPs with antidiabetic activity, especially those isolated from amphibians. These peptides can induce insulin release via different mechanisms based on peptide type. In this review study, we collected all reported AMPs with antidiabetic activity. We also analyze the sequence and structure of these peptides for evaluation of sequence and structure effect on their antidiabetic activity. Based on this review, the biggest peptide family with antidiabetic activity is temporins with nine antidiabetic peptides. Frogs are the most abundant source of antidiabetic peptides. Bioinformatics analysis showed that an increase of positive net charge and a decrease of hydrophobicity can improve the insulinotropic effect of peptides. Peptides with higher positive net charge and Boman index showed higher activity. Based on this review article, AMPs with antidiabetic activity, especially those isolated from amphibians, can be used as novel antidiabetic drug for type 2 diabetes disease. So, amphibians are potential sources for active peptides which merit further evaluation as novel insulin secretagogues. However, strategy for the increase of stability and positive activity as well as the decrease of negative side effects must be considered. |
| format | Article |
| id | doaj-art-60876ceda41c4ec3bec2405b376badb7 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-60876ceda41c4ec3bec2405b376badb72025-08-20T02:35:19ZengWileyJournal of Diabetes Research2314-67452314-67532021-01-01202110.1155/2021/28947222894722Antimicrobial Peptides from Amphibian Innate Immune System as Potent Antidiabetic Agents: A Literature Review and Bioinformatics AnalysisHossein Soltaninejad0Hadi Zare-Zardini1Mahtab Ordooei2Yaser Ghelmani3Akram Ghadiri-Anari4Sanaz Mojahedi5Amir Ali Hamidieh6Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, IranMedical Nanotechnology and Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, IranHematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IranClinical Research Development Center of Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Internal Medicine, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Biology, Faculty of Sciences, Science and Arts University, Yazd, IranPediatric Cell and Gene Therapy Research Center, Tehran University of Medical Sciences, Tehran, IranAntimicrobial peptides, as an important member of the innate immune system, have various biological activities in addition to antimicrobial activity. There are some AMPs with antidiabetic activity, especially those isolated from amphibians. These peptides can induce insulin release via different mechanisms based on peptide type. In this review study, we collected all reported AMPs with antidiabetic activity. We also analyze the sequence and structure of these peptides for evaluation of sequence and structure effect on their antidiabetic activity. Based on this review, the biggest peptide family with antidiabetic activity is temporins with nine antidiabetic peptides. Frogs are the most abundant source of antidiabetic peptides. Bioinformatics analysis showed that an increase of positive net charge and a decrease of hydrophobicity can improve the insulinotropic effect of peptides. Peptides with higher positive net charge and Boman index showed higher activity. Based on this review article, AMPs with antidiabetic activity, especially those isolated from amphibians, can be used as novel antidiabetic drug for type 2 diabetes disease. So, amphibians are potential sources for active peptides which merit further evaluation as novel insulin secretagogues. However, strategy for the increase of stability and positive activity as well as the decrease of negative side effects must be considered.http://dx.doi.org/10.1155/2021/2894722 |
| spellingShingle | Hossein Soltaninejad Hadi Zare-Zardini Mahtab Ordooei Yaser Ghelmani Akram Ghadiri-Anari Sanaz Mojahedi Amir Ali Hamidieh Antimicrobial Peptides from Amphibian Innate Immune System as Potent Antidiabetic Agents: A Literature Review and Bioinformatics Analysis Journal of Diabetes Research |
| title | Antimicrobial Peptides from Amphibian Innate Immune System as Potent Antidiabetic Agents: A Literature Review and Bioinformatics Analysis |
| title_full | Antimicrobial Peptides from Amphibian Innate Immune System as Potent Antidiabetic Agents: A Literature Review and Bioinformatics Analysis |
| title_fullStr | Antimicrobial Peptides from Amphibian Innate Immune System as Potent Antidiabetic Agents: A Literature Review and Bioinformatics Analysis |
| title_full_unstemmed | Antimicrobial Peptides from Amphibian Innate Immune System as Potent Antidiabetic Agents: A Literature Review and Bioinformatics Analysis |
| title_short | Antimicrobial Peptides from Amphibian Innate Immune System as Potent Antidiabetic Agents: A Literature Review and Bioinformatics Analysis |
| title_sort | antimicrobial peptides from amphibian innate immune system as potent antidiabetic agents a literature review and bioinformatics analysis |
| url | http://dx.doi.org/10.1155/2021/2894722 |
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