Do gender differences matter in Acute Heart Failure? Insights from Indian College of Cardiology – National Heart Failure Registry, India
Background: Real-world investigations focused on gender-associated characteristics of Acute Heart failure (AHF) are lacking. The current study, from a national heart failure registry, aims to investigate gender-based patterns and outcomes among AHF patients in India. Methods: This prospective Indian...
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2025-09-01
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| Series: | International Journal of Cardiology. Cardiovascular Risk and Prevention |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772487525000790 |
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| author | P.B. Jayagopal C.N. Manjunath A. Jabir Sridhar L. Sastry Veena Nanjappa P.R. Vaidyanathan Johny Joseph Soma Sekhar Ghanta P. Manokar Nitin Kabra Dharmendra Jain Vinod Sharma Trinath Kumar Mishra R. Badri Narayanan Narendra Jathappa Gautam Rege Sunil Modi S.N. Routray T.R. Raghu Rabin Chakraborty Dayasagar Rao Shantanu Sengupta K.S. Ravindranath B.C. Srinivas V.K. Chopra |
| author_facet | P.B. Jayagopal C.N. Manjunath A. Jabir Sridhar L. Sastry Veena Nanjappa P.R. Vaidyanathan Johny Joseph Soma Sekhar Ghanta P. Manokar Nitin Kabra Dharmendra Jain Vinod Sharma Trinath Kumar Mishra R. Badri Narayanan Narendra Jathappa Gautam Rege Sunil Modi S.N. Routray T.R. Raghu Rabin Chakraborty Dayasagar Rao Shantanu Sengupta K.S. Ravindranath B.C. Srinivas V.K. Chopra |
| author_sort | P.B. Jayagopal |
| collection | DOAJ |
| description | Background: Real-world investigations focused on gender-associated characteristics of Acute Heart failure (AHF) are lacking. The current study, from a national heart failure registry, aims to investigate gender-based patterns and outcomes among AHF patients in India. Methods: This prospective Indian College of Cardiology National Heart Failure Registry enrolled patients admitted with AHF in 17 centres from 2019 to 2021. Demographics, aetiology, co-morbidities, laboratory investigations, electrocardiogram, and echo parameters were captured. In-hospital 30-day and one-year mortality rates were recorded. The prescription and adherence to the three Guideline Directed Medical Therapy (GDMT) prescription in 2019–2021 were also captured at discharge. Mortality rate Gender-based comparisons were tested at a 5 % level of significance. Results: The study enrolled 5182 AHF patients, 66.7 % male (M) and 33.3 % female (F). The mean age of the male (M) population was 60.9 ± 13.3, and the female (F) population was 62.8 ± 14 years. Women had a higher prevalence of heart failure with preserved ejection fraction (HFpEF)(F:12.9 %, M:7.3 %;P < 0.0001), hypertension (F: 57.2 %, M: 52.4 %; P = 0.0011) and arrhythmia (F:15.2 %, M:11.7 %;P = 0.0005). Men had a higher incidence of ischemic heart disease (M:76.2 %, F:67.5 %; P < 0.001). Adherence to Renin-angiotensin-aldosterone system (RAAS) inhibitors, Beta-blockers and Mineralocorticoid receptor antagonists (MRAs) was low (18.8 % (M); 15.9 % (F)). The mortality rate, in-hospital mortality was 6.9 % (M:6.5 %, F:7.7 %), up to one-month was 11.8 % (M:11.6 %, F:12.3 %) or one-year was 18.1 % (M:17.8 %, F:18.6 %). Conclusion: Women represent one-third of the population with AHF. Hypertension and HFpEF were more common in women, while ischemic heart disease was more prevalent in men. No gender-based differences were observed in the mortality outcomes. Both groups had low GDMT adherence. This calls for effective strategies to improve HF care in the country. |
| format | Article |
| id | doaj-art-6086b854bf1c47bda9ee331d6285cfed |
| institution | Kabale University |
| issn | 2772-4875 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology. Cardiovascular Risk and Prevention |
| spelling | doaj-art-6086b854bf1c47bda9ee331d6285cfed2025-08-24T05:15:16ZengElsevierInternational Journal of Cardiology. Cardiovascular Risk and Prevention2772-48752025-09-012620044110.1016/j.ijcrp.2025.200441Do gender differences matter in Acute Heart Failure? Insights from Indian College of Cardiology – National Heart Failure Registry, IndiaP.B. Jayagopal0C.N. Manjunath1A. Jabir2Sridhar L. Sastry3Veena Nanjappa4P.R. Vaidyanathan5Johny Joseph6Soma Sekhar Ghanta7P. Manokar8Nitin Kabra9Dharmendra Jain10Vinod Sharma11Trinath Kumar Mishra12R. Badri Narayanan13Narendra Jathappa14Gautam Rege15Sunil Modi16S.N. Routray17T.R. Raghu18Rabin Chakraborty19Dayasagar Rao20Shantanu Sengupta21K.S. Ravindranath22B.C. Srinivas23V.K. Chopra24Lakshmi Hospital, Chittur Road, Palakkad, Kerala, 678013, India; Corresponding author. Department of Cardiology, Lakshmi Hospital, Chittur Rd, Palakkad, Kerala, 678013, IndiaSri Jayadeva Institute of Cardiovascular Sciences & Research, Kumbarakoppal, Vijay Nagar, Gokulam 3rd Stage, Mahadeshwara Badavane Layout, Mysuru, Karnataka, 570016, IndiaLisie Hospital, Lisie Hospital Rd, North Kaloor, Kaloor, Ernakulam, Kerala, 682018, IndiaSri Jayadeva Institute of Cardiovascular Sciences & Research, Kumbarakoppal, Vijay Nagar, Gokulam 3rd Stage, Mahadeshwara Badavane Layout, Mysuru, Karnataka, 570016, IndiaSri Jayadeva Institute of Cardiovascular Sciences & Research, Kumbarakoppal, Vijay Nagar, Gokulam 3rd Stage, Mahadeshwara Badavane Layout, Mysuru, Karnataka, 570016, IndiaG. Kuppuswamy Naidu Memorial Hospital, Netaji Rd, Pappanaickenpalayam, Coimbatore, Tamil Nadu, 641037, IndiaCaritas Hospital - Multispeciality Hospital, Thellakom, Kottayam, Kerala, 686630, IndiaAayush Hospitals, Vijayawada, Ring Road Opp.Siddhartha Medical College, Sri Ramachandra Nagar, Vijayawada, Andhra Pradesh, 520008, IndiaSri Ramachandra University, No.1 Ramachandra Nagar Porur, Chennai, 600 116, IndiaGandhi Medical College, Musheerabad, Padmarao Nagar, Secunderabad, Telangana, 500003, IndiaInstitute of Medical Science, Banaras Hindu University, Aurobindo Colony, Bhelupur, Varanasi, Uttar Pradesh, 221005, IndiaNational Heart Institute, 49/50 Community Center, East of Kailash, New Delhi, Delhi, 110065, IndiaMKCG Medical College & Hospital, Medical College Campus, NH59, Brahmapur, Odisha, 760004, IndiaKIMS – Near Red Bridge Chaitanya Health City, Amalapuram, Andhrapradesh, 533201, IndiaNanjappa Multi-Speciality Hospital, Kuvempu Rd, Tilak Nagar, Durgigudi, Shivamogga, Karnataka, 577201, IndiaJupiter Hospital, Near Prathamesh Park, Baner, Pimple Nilakh Road, Pune, Maharashtra, 411 045, IndiaIndraprastha Apollo Hospital, NH-19, New Delhi, Delhi, 110076, IndiaSCB, Cuttack, Odisha – Behera Colony, Mangalabag, Cuttack, Odisha 753001, IndiaRajaRajeswari Medical College and Hospital, 202, Mysore Rd, Kengeri Satellite Town, Kambipura, Karnataka 560074, IndiaMedica Super Speciality Hospital, 127, Eastern Metropolitan Bypass Rd, Nitai Nagar, Mukundapur, Kolkata, West Bengal 700099, IndiaKrishna Institute of Medical Sciences, 1-8-31/1, Minister Road, Krishna Nagar Colony, Begumpet, Near Krishna Nagar Colony, Secunderabad, 500003, IndiaSengupta Hospital and Research Institute, Amravati Rd, Ravi Nagar, Tilak Nagar, Gokulpeth, Nagpur, Maharashtra 440033, IndiaSri Jayadeva Institute of Cardiovascular Sciences & Research, Kumbarakoppal, Vijay Nagar, Gokulam 3rd Stage, Mahadeshwara Badavane Layout, Mysuru, Karnataka, 570016, IndiaSri Jayadeva Institute of Cardiovascular Sciences & Research, Kumbarakoppal, Vijay Nagar, Gokulam 3rd Stage, Mahadeshwara Badavane Layout, Mysuru, Karnataka, 570016, IndiaMax Super Speciality, DELHI, 1&2, Press Enclave Road, Hauz Rani Bus Stop, Saket, Delhi, 110017, IndiaBackground: Real-world investigations focused on gender-associated characteristics of Acute Heart failure (AHF) are lacking. The current study, from a national heart failure registry, aims to investigate gender-based patterns and outcomes among AHF patients in India. Methods: This prospective Indian College of Cardiology National Heart Failure Registry enrolled patients admitted with AHF in 17 centres from 2019 to 2021. Demographics, aetiology, co-morbidities, laboratory investigations, electrocardiogram, and echo parameters were captured. In-hospital 30-day and one-year mortality rates were recorded. The prescription and adherence to the three Guideline Directed Medical Therapy (GDMT) prescription in 2019–2021 were also captured at discharge. Mortality rate Gender-based comparisons were tested at a 5 % level of significance. Results: The study enrolled 5182 AHF patients, 66.7 % male (M) and 33.3 % female (F). The mean age of the male (M) population was 60.9 ± 13.3, and the female (F) population was 62.8 ± 14 years. Women had a higher prevalence of heart failure with preserved ejection fraction (HFpEF)(F:12.9 %, M:7.3 %;P < 0.0001), hypertension (F: 57.2 %, M: 52.4 %; P = 0.0011) and arrhythmia (F:15.2 %, M:11.7 %;P = 0.0005). Men had a higher incidence of ischemic heart disease (M:76.2 %, F:67.5 %; P < 0.001). Adherence to Renin-angiotensin-aldosterone system (RAAS) inhibitors, Beta-blockers and Mineralocorticoid receptor antagonists (MRAs) was low (18.8 % (M); 15.9 % (F)). The mortality rate, in-hospital mortality was 6.9 % (M:6.5 %, F:7.7 %), up to one-month was 11.8 % (M:11.6 %, F:12.3 %) or one-year was 18.1 % (M:17.8 %, F:18.6 %). Conclusion: Women represent one-third of the population with AHF. Hypertension and HFpEF were more common in women, while ischemic heart disease was more prevalent in men. No gender-based differences were observed in the mortality outcomes. Both groups had low GDMT adherence. This calls for effective strategies to improve HF care in the country.http://www.sciencedirect.com/science/article/pii/S2772487525000790Acute heart failureHeart failure registryGender differencesAdherencePrescription pattern |
| spellingShingle | P.B. Jayagopal C.N. Manjunath A. Jabir Sridhar L. Sastry Veena Nanjappa P.R. Vaidyanathan Johny Joseph Soma Sekhar Ghanta P. Manokar Nitin Kabra Dharmendra Jain Vinod Sharma Trinath Kumar Mishra R. Badri Narayanan Narendra Jathappa Gautam Rege Sunil Modi S.N. Routray T.R. Raghu Rabin Chakraborty Dayasagar Rao Shantanu Sengupta K.S. Ravindranath B.C. Srinivas V.K. Chopra Do gender differences matter in Acute Heart Failure? Insights from Indian College of Cardiology – National Heart Failure Registry, India International Journal of Cardiology. Cardiovascular Risk and Prevention Acute heart failure Heart failure registry Gender differences Adherence Prescription pattern |
| title | Do gender differences matter in Acute Heart Failure? Insights from Indian College of Cardiology – National Heart Failure Registry, India |
| title_full | Do gender differences matter in Acute Heart Failure? Insights from Indian College of Cardiology – National Heart Failure Registry, India |
| title_fullStr | Do gender differences matter in Acute Heart Failure? Insights from Indian College of Cardiology – National Heart Failure Registry, India |
| title_full_unstemmed | Do gender differences matter in Acute Heart Failure? Insights from Indian College of Cardiology – National Heart Failure Registry, India |
| title_short | Do gender differences matter in Acute Heart Failure? Insights from Indian College of Cardiology – National Heart Failure Registry, India |
| title_sort | do gender differences matter in acute heart failure insights from indian college of cardiology national heart failure registry india |
| topic | Acute heart failure Heart failure registry Gender differences Adherence Prescription pattern |
| url | http://www.sciencedirect.com/science/article/pii/S2772487525000790 |
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