PHARMACEUTICAL CORRECTION OF VASCULAR DISTURBANCES IN PATIENTS WITH ARTERIAL HYPERTENSION
Aim: To study vascular stiffness and elasticity, microcirculation (MC) parameters, and mildronate effects in patients with arterial hypertension (AH). Material and methods. The study included 99 patients with Stage I-II AH (mean age 63,2+2,6 years). Pulse wave velocity was assessed by volume sphygmo...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2010-10-01
|
| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1492 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849250699307646976 |
|---|---|
| author | L. A. Khaisheva S. V. Shlyk S. E. Glova T. Yu. Bykovskaya O. N. Goncharova |
| author_facet | L. A. Khaisheva S. V. Shlyk S. E. Glova T. Yu. Bykovskaya O. N. Goncharova |
| author_sort | L. A. Khaisheva |
| collection | DOAJ |
| description | Aim: To study vascular stiffness and elasticity, microcirculation (MC) parameters, and mildronate effects in patients with arterial hypertension (AH). Material and methods. The study included 99 patients with Stage I-II AH (mean age 63,2+2,6 years). Pulse wave velocity was assessed by volume sphygmography (Poly-Spectre system, Neuro-Soft). MC parameters were assessed with a computerised Doppler ultrasound device (Minimax-Doppler-K). After a wash-out period, the participants were randomised into 2 groups. Group I received enalapril (Renipril, Pharmstandard; 10 mg/d) and mildronate (0,25 g twice a day). Group II was administered Renipril (10 mg/d) only. Results. After 12 weeks of the treatment, blood pressure (BP) levels were significantly reduced. In Group I, a significant increase in mean linear blood flow velocity after occlusion test, as well as in volume blood flow velocity, was observed, compared to the baseline. In 66% of the patients, blood flow velocity after occlusion test was increased by at least 20%. Conclusion. Adding mildronate to the standard antihypertensive therapy with ACE inhibitors facilitates faster normalisation of vascular function. |
| format | Article |
| id | doaj-art-607bc74810e64292b8b18ef32ae1b69b |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2010-10-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-607bc74810e64292b8b18ef32ae1b69b2025-08-20T03:57:11Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202010-10-010535401279PHARMACEUTICAL CORRECTION OF VASCULAR DISTURBANCES IN PATIENTS WITH ARTERIAL HYPERTENSIONL. A. Khaisheva0S. V. Shlyk1S. E. Glova2T. Yu. Bykovskaya3O. N. Goncharova4Ростовский государственный медицинский университет, Ростов-на-Дону, РоссияРостовский государственный медицинский университет, Ростов-на-Дону, РоссияРостовский государственный медицинский университет, Ростов-на-Дону, РоссияРостовский государственный медицинский университет, Ростов-на-Дону, РоссияРостовский государственный медицинский университет, Ростов-на-Дону, РоссияAim: To study vascular stiffness and elasticity, microcirculation (MC) parameters, and mildronate effects in patients with arterial hypertension (AH). Material and methods. The study included 99 patients with Stage I-II AH (mean age 63,2+2,6 years). Pulse wave velocity was assessed by volume sphygmography (Poly-Spectre system, Neuro-Soft). MC parameters were assessed with a computerised Doppler ultrasound device (Minimax-Doppler-K). After a wash-out period, the participants were randomised into 2 groups. Group I received enalapril (Renipril, Pharmstandard; 10 mg/d) and mildronate (0,25 g twice a day). Group II was administered Renipril (10 mg/d) only. Results. After 12 weeks of the treatment, blood pressure (BP) levels were significantly reduced. In Group I, a significant increase in mean linear blood flow velocity after occlusion test, as well as in volume blood flow velocity, was observed, compared to the baseline. In 66% of the patients, blood flow velocity after occlusion test was increased by at least 20%. Conclusion. Adding mildronate to the standard antihypertensive therapy with ACE inhibitors facilitates faster normalisation of vascular function.https://russjcardiol.elpub.ru/jour/article/view/1492arterial hypertensionvascular disturbancescardioprotection |
| spellingShingle | L. A. Khaisheva S. V. Shlyk S. E. Glova T. Yu. Bykovskaya O. N. Goncharova PHARMACEUTICAL CORRECTION OF VASCULAR DISTURBANCES IN PATIENTS WITH ARTERIAL HYPERTENSION Российский кардиологический журнал arterial hypertension vascular disturbances cardioprotection |
| title | PHARMACEUTICAL CORRECTION OF VASCULAR DISTURBANCES IN PATIENTS WITH ARTERIAL HYPERTENSION |
| title_full | PHARMACEUTICAL CORRECTION OF VASCULAR DISTURBANCES IN PATIENTS WITH ARTERIAL HYPERTENSION |
| title_fullStr | PHARMACEUTICAL CORRECTION OF VASCULAR DISTURBANCES IN PATIENTS WITH ARTERIAL HYPERTENSION |
| title_full_unstemmed | PHARMACEUTICAL CORRECTION OF VASCULAR DISTURBANCES IN PATIENTS WITH ARTERIAL HYPERTENSION |
| title_short | PHARMACEUTICAL CORRECTION OF VASCULAR DISTURBANCES IN PATIENTS WITH ARTERIAL HYPERTENSION |
| title_sort | pharmaceutical correction of vascular disturbances in patients with arterial hypertension |
| topic | arterial hypertension vascular disturbances cardioprotection |
| url | https://russjcardiol.elpub.ru/jour/article/view/1492 |
| work_keys_str_mv | AT lakhaisheva pharmaceuticalcorrectionofvasculardisturbancesinpatientswitharterialhypertension AT svshlyk pharmaceuticalcorrectionofvasculardisturbancesinpatientswitharterialhypertension AT seglova pharmaceuticalcorrectionofvasculardisturbancesinpatientswitharterialhypertension AT tyubykovskaya pharmaceuticalcorrectionofvasculardisturbancesinpatientswitharterialhypertension AT ongoncharova pharmaceuticalcorrectionofvasculardisturbancesinpatientswitharterialhypertension |