Inflammasomes and Signaling Pathways: Key Mechanisms in the Pathophysiology of Sepsis

Inflammasomes and Signaling Pathways: Key Mechanisms in the Pathophysiology of Sepsis

Sepsis is a life-threatening syndrome characterized by a dysregulated immune response to infection, frequently leading to multiorgan failure and high mortality. Inflammasomes—cytosolic multiprotein complexes of the innate immune system—serve as critical platforms for sensing pathogen- and damage-ass...

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Main Authors: Jhan S. Saavedra-Torres, María Virginia Pinzón-Fernández, Martin Ocampo-Posada, H. A. Nati-Castillo, Laura Alejandra Jiménez Hincapie, Eder J. Cadrazo-Gil, Marlon Arias-Intriago, Marlon Rojas-Cadena, Andrea Tello-De-la-Torre, Walter Osejos, Juan S. Izquierdo-Condoy
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
sepsis
inflammasome
pyroptosis
cytokines
coagulation
immunomodulation
Online Access:https://www.mdpi.com/2073-4409/14/12/930
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