Bat Influenza M2 Shows Functions Similar to Those of Classical Influenza A Viruses
Novel bat influenza viruses show different features in contrast to classical influenza A viruses (IAVs). The M2 of IAVs functions as an ion channel that plays an important role in virus entry, viral assembly, and release and also serves as the antiviral target. To date, whether bat influenza M2 func...
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MDPI AG
2025-06-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/14/6/599 |
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| author | Wenyu Yang Liping Wang Lei Shi Jialin Zhang Heidi Liu Jun Wang Wenjun Ma |
| author_facet | Wenyu Yang Liping Wang Lei Shi Jialin Zhang Heidi Liu Jun Wang Wenjun Ma |
| author_sort | Wenyu Yang |
| collection | DOAJ |
| description | Novel bat influenza viruses show different features in contrast to classical influenza A viruses (IAVs). The M2 of IAVs functions as an ion channel that plays an important role in virus entry, viral assembly, and release and also serves as the antiviral target. To date, whether bat influenza M2 functions as the ion channel like classical IAV M2 remains unknown. Here, we show that the bat influenza M2 amino acid at position 31 (N/S) is critical for sensitivity to antivirals targeting the ion channel such as amantadine and other tested antivirals and that the amino acids at position 37 (H/G) and 41 (W/A) are crucial for virus replication and survival. The results indicate that bat influenza M2 functions similarly to conventional IAVs despite the low identity between the two. |
| format | Article |
| id | doaj-art-607aa8b7e96b4ecdb72debd282a9ba50 |
| institution | Kabale University |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj-art-607aa8b7e96b4ecdb72debd282a9ba502025-08-20T03:27:36ZengMDPI AGPathogens2076-08172025-06-0114659910.3390/pathogens14060599Bat Influenza M2 Shows Functions Similar to Those of Classical Influenza A VirusesWenyu Yang0Liping Wang1Lei Shi2Jialin Zhang3Heidi Liu4Jun Wang5Wenjun Ma6Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USADepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USADepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USADepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USADepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USADepartment of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USADepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USANovel bat influenza viruses show different features in contrast to classical influenza A viruses (IAVs). The M2 of IAVs functions as an ion channel that plays an important role in virus entry, viral assembly, and release and also serves as the antiviral target. To date, whether bat influenza M2 functions as the ion channel like classical IAV M2 remains unknown. Here, we show that the bat influenza M2 amino acid at position 31 (N/S) is critical for sensitivity to antivirals targeting the ion channel such as amantadine and other tested antivirals and that the amino acids at position 37 (H/G) and 41 (W/A) are crucial for virus replication and survival. The results indicate that bat influenza M2 functions similarly to conventional IAVs despite the low identity between the two.https://www.mdpi.com/2076-0817/14/6/599bat influenza M2antiviral resistanceion channel |
| spellingShingle | Wenyu Yang Liping Wang Lei Shi Jialin Zhang Heidi Liu Jun Wang Wenjun Ma Bat Influenza M2 Shows Functions Similar to Those of Classical Influenza A Viruses Pathogens bat influenza M2 antiviral resistance ion channel |
| title | Bat Influenza M2 Shows Functions Similar to Those of Classical Influenza A Viruses |
| title_full | Bat Influenza M2 Shows Functions Similar to Those of Classical Influenza A Viruses |
| title_fullStr | Bat Influenza M2 Shows Functions Similar to Those of Classical Influenza A Viruses |
| title_full_unstemmed | Bat Influenza M2 Shows Functions Similar to Those of Classical Influenza A Viruses |
| title_short | Bat Influenza M2 Shows Functions Similar to Those of Classical Influenza A Viruses |
| title_sort | bat influenza m2 shows functions similar to those of classical influenza a viruses |
| topic | bat influenza M2 antiviral resistance ion channel |
| url | https://www.mdpi.com/2076-0817/14/6/599 |
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