Links between short-chain fatty acids and osteoarthritis from pathology to clinic via gut-joint axis

Links between short-chain fatty acids and osteoarthritis from pathology to clinic via gut-joint axis

Abstract Short-chain fatty acids (SCFAs), the primary metabolites produced by the microbial fermentation of dietary fibers in the gut, have a key role in protecting gut health. Increasing evidence indicates SCFAs can exert effects on distant tissues and organs beyond the gut via blood circulation. O...

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Bibliographic Details
Main Authors: Juanjuan Han, Xin Meng, Hui Kong, Xinran Li, Peijie Chen, Xin-an Zhang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Stem Cell Research & Therapy
Subjects:
Short-chain fatty acids
Osteoarthritis
Gut-Joint Axis
Butyrate
Dietary fibers
Probiotics and prebiotics
Online Access:https://doi.org/10.1186/s13287-025-04386-3
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