Unraveling the nexus: Sleep's role in ferroptosis and health
Sleep is an important physiological process to maintain physiological health, which involves the regulation of many systems in the body, which is not only closely related to hormone balance, immune system and nervous system function in the body. Recent studies have emphasized the complex relationshi...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025002242 |
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| author | Peng-cheng Zhao Zhen-yu Wu Yu-hang Zhu Tao-wu Gong Zhao-qiong Zhu |
| author_facet | Peng-cheng Zhao Zhen-yu Wu Yu-hang Zhu Tao-wu Gong Zhao-qiong Zhu |
| author_sort | Peng-cheng Zhao |
| collection | DOAJ |
| description | Sleep is an important physiological process to maintain physiological health, which involves the regulation of many systems in the body, which is not only closely related to hormone balance, immune system and nervous system function in the body. Recent studies have emphasized the complex relationship between sleep and cell death mechanisms. Ferroptosis is a form of iron-dependent cell death, which is related to a variety of neurodegenerative diseases. Sleep plays an important role in regulating brain metabolism, immune function and overall intracellular homeostasis. New evidence suggests that there is a two-way interaction between sleep and ferroptosis. Sleep interruption may enhance the ferroptosis pathway, which in turn may change the quality of sleep. Understanding this interaction is essential to reveal the underlying mechanisms of neurodegeneration and to develop potential therapeutic interventions.This review combines the results of current studies on the molecular and cellular mechanisms of ferroptosis and the extensive role of sleep in brain health. Special attention is paid to the effects of sleep deprivation on iron metabolism and oxidative stress, which play an important role in ferroptosis. The review also explores the role of sleep in regulating iron homeostasis and how sleep disorders promote iron accumulation in the brain, which may accelerate the process of ferroptosis.Sleep disorders, especially chronic sleep deprivation, may create a favorable environment for ferroptosis by affecting iron metabolism and oxidative stress levels in the brain. Conversely, cell death associated with siderosis disrupts normal sleep patterns, forming a circulatory relationship that exacerbates neurodegenerative diseases. Understanding the complex mechanisms of sleep and ferroptosis will provide valuable insights into aging and age-related diseases. In addition, the pathways involved in sleep regulation and ferroptosis can provide new methods for the prevention and treatment of neurodegenerative diseases and other ferroptosis-related pathology. |
| format | Article |
| id | doaj-art-60775bd223f142d29706157259d27613 |
| institution | DOAJ |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-60775bd223f142d29706157259d276132025-08-20T03:10:29ZengElsevierBrain Research Bulletin1873-27472025-08-0122811141210.1016/j.brainresbull.2025.111412Unraveling the nexus: Sleep's role in ferroptosis and healthPeng-cheng Zhao0Zhen-yu Wu1Yu-hang Zhu2Tao-wu Gong3Zhao-qiong Zhu4Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, China; Department of Anesthesiology, The Frist People’s Hospital of Zunyi, ChinaDepartment of Anesthesiology, Affiliated Hospital of Zunyi Medical University, ChinaEarly Clinical Research Ward, Affiliated Hospital of Zunyi Medical University, ChinaDepartment of Anesthesiology, Affiliated Hospital of Zunyi Medical University, ChinaEarly Clinical Research Ward, Affiliated Hospital of Zunyi Medical University, China; Corresponding author.Sleep is an important physiological process to maintain physiological health, which involves the regulation of many systems in the body, which is not only closely related to hormone balance, immune system and nervous system function in the body. Recent studies have emphasized the complex relationship between sleep and cell death mechanisms. Ferroptosis is a form of iron-dependent cell death, which is related to a variety of neurodegenerative diseases. Sleep plays an important role in regulating brain metabolism, immune function and overall intracellular homeostasis. New evidence suggests that there is a two-way interaction between sleep and ferroptosis. Sleep interruption may enhance the ferroptosis pathway, which in turn may change the quality of sleep. Understanding this interaction is essential to reveal the underlying mechanisms of neurodegeneration and to develop potential therapeutic interventions.This review combines the results of current studies on the molecular and cellular mechanisms of ferroptosis and the extensive role of sleep in brain health. Special attention is paid to the effects of sleep deprivation on iron metabolism and oxidative stress, which play an important role in ferroptosis. The review also explores the role of sleep in regulating iron homeostasis and how sleep disorders promote iron accumulation in the brain, which may accelerate the process of ferroptosis.Sleep disorders, especially chronic sleep deprivation, may create a favorable environment for ferroptosis by affecting iron metabolism and oxidative stress levels in the brain. Conversely, cell death associated with siderosis disrupts normal sleep patterns, forming a circulatory relationship that exacerbates neurodegenerative diseases. Understanding the complex mechanisms of sleep and ferroptosis will provide valuable insights into aging and age-related diseases. In addition, the pathways involved in sleep regulation and ferroptosis can provide new methods for the prevention and treatment of neurodegenerative diseases and other ferroptosis-related pathology.http://www.sciencedirect.com/science/article/pii/S0361923025002242SleepFerroptosisOxidative stressCognitive |
| spellingShingle | Peng-cheng Zhao Zhen-yu Wu Yu-hang Zhu Tao-wu Gong Zhao-qiong Zhu Unraveling the nexus: Sleep's role in ferroptosis and health Brain Research Bulletin Sleep Ferroptosis Oxidative stress Cognitive |
| title | Unraveling the nexus: Sleep's role in ferroptosis and health |
| title_full | Unraveling the nexus: Sleep's role in ferroptosis and health |
| title_fullStr | Unraveling the nexus: Sleep's role in ferroptosis and health |
| title_full_unstemmed | Unraveling the nexus: Sleep's role in ferroptosis and health |
| title_short | Unraveling the nexus: Sleep's role in ferroptosis and health |
| title_sort | unraveling the nexus sleep s role in ferroptosis and health |
| topic | Sleep Ferroptosis Oxidative stress Cognitive |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025002242 |
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