Lipid nanoparticle-delivered IFNα2 activates Cxcl9 to increase T cell tumor recruitment to suppress lung metastasis

Lipid nanoparticle-delivered IFNα2 activates Cxcl9 to increase T cell tumor recruitment to suppress lung metastasis

Background Emerging clinical and mouse tumor data indicate that tumor cells induce immune suppression in an anatomical site-specific manner. In lung metastases, tumor cell programmed death-ligand 1 (PD-L1) engages myeloid cell programmed cell death protein 1 to activate SHP2 to suppress type I inter...

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Bibliographic Details
Main Authors: Yang Zhao, Valentyna Fesenkova, Kebin Liu, Dafeng Yang, Rafal Pacholczyk, Yi Tang, Dakota Poschel, Huidong Shi, Jin Xie, Kendra Fick, Nicholas Kerns, Zainab Tiamiyu, Patrick Czabala, Priscilla S Redd
Format: Article
Language:English
Published: BMJ Publishing Group 2025-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/7/e011415.full
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