Selective Pyk2 inhibition enhances bone restoration through SCARA5-mediated bone marrow remodeling in ovariectomized mice

Selective Pyk2 inhibition enhances bone restoration through SCARA5-mediated bone marrow remodeling in ovariectomized mice

Abstract Understanding the intricate cellular interactions involved in bone restoration is crucial for developing effective strategies to promote bone healing and mitigate conditions such as osteoporosis and fractures. Here, we provide compelling evidence supporting the anabolic effects of a pharmac...

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Main Authors: Yunqing Liu, Mai Nishiura, Mika Fujii, Sumiti Sandhu, Yasutaka Yawaka, Yutaka Yamazaki, Akira Hasebe, Tadahiro Iimura, Sek Won Kong, Ji-Won Lee
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cell Communication and Signaling
Subjects:
Pyk2
Bone
Mesenchymal stem cell
Osteoclast
Osteoblast
Adipocyte
Online Access:https://doi.org/10.1186/s12964-024-01945-8
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