A decade of insight: Understanding primary Leiomyosarcoma of the bone
Purpose: To investigate the clinical, radiological, histopathological features, survival outcomes, and prognostic factors of the rare primary leiomyosarcoma of bone (PBLMS). Methods: This was a retrospective study conducted between the year 2012–2022. 16 patients had biopsy-proven PBLMS out of 632 p...
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Elsevier
2025-04-01
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| Series: | Journal of Orthopaedic Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773157X25000086 |
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| author | Himanshu Rohela Anila Sharma Vaibhav Sahu Sunil Pasricha Ullas Batra Kundan Singh Chufal Akshay Tiwari Manish Pruthi Gurudutt Gupta Anurag Mehta |
| author_facet | Himanshu Rohela Anila Sharma Vaibhav Sahu Sunil Pasricha Ullas Batra Kundan Singh Chufal Akshay Tiwari Manish Pruthi Gurudutt Gupta Anurag Mehta |
| author_sort | Himanshu Rohela |
| collection | DOAJ |
| description | Purpose: To investigate the clinical, radiological, histopathological features, survival outcomes, and prognostic factors of the rare primary leiomyosarcoma of bone (PBLMS). Methods: This was a retrospective study conducted between the year 2012–2022. 16 patients had biopsy-proven PBLMS out of 632 primary bone sarcomas. Data was collected on patient details, tumor characteristics, treatment, and outcomes. Results: The study included 12 males and 4 females with a median age of 26.5 years. Common sites were femur (62 %), tibia (32 %), and humerus (6 %). Pathological fractures occurred in 19 %. Surgery was the primary treatment-limb salvage in 87.5 %, amputation in 12.5 % of the patients. Neo-adjuvant chemotherapy was given in 3 patients. Adjuvant chemotherapy and radiotherapy were given in 10 and 2 patients, respectively. One patient had local recurrence. Five patients developed distant metastasis. The 5-year OS and EFS rates were 62.5 % and 58.5 %, respectively. Higher tumor grade, local recurrence, and distant metastasis adversely impacted OS (p value < 0.05). Positive margins, pathological fracture, and distant metastasis negatively affected local recurrence. Conclusions: PBLMS is an aggressive sarcoma with high metastatic potential. Early detection and complete surgical resection with negative margins are crucial. The benefit of chemotherapy and radiotherapy remains unclear. Distant metastasis was the most significant adverse prognostic factor for overall survival. |
| format | Article |
| id | doaj-art-6067bfa33c334322aa3fad9d76af7749 |
| institution | Kabale University |
| issn | 2773-157X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Reports |
| spelling | doaj-art-6067bfa33c334322aa3fad9d76af77492025-08-20T03:31:24ZengElsevierJournal of Orthopaedic Reports2773-157X2025-04-014110055610.1016/j.jorep.2025.100556A decade of insight: Understanding primary Leiomyosarcoma of the boneHimanshu Rohela0Anila Sharma1Vaibhav Sahu2Sunil Pasricha3Ullas Batra4Kundan Singh Chufal5Akshay Tiwari6Manish Pruthi7Gurudutt Gupta8Anurag Mehta9Department of Musculoskeletal Surgical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, IndiaDepartment of Pathology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, IndiaDepartment of Musculoskeletal Surgical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, India; Corresponding author. Department of Musculoskeletal Surgical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, Sir Chotu Ram Marg, Rohini Institutional Area, Sector 5 Rohini, 110085, New Delhi, India.Department of Pathology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, IndiaDepartment of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, IndiaDepartment of Radiation Oncology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, IndiaDepartment of Musculoskeletal Surgical Oncology, Max Institute of Cancer Care, New Delhi, IndiaDepartment of Musculoskeletal Surgical Oncology, Tata Memorial Hospital, Mumbai, IndiaDepartment of Pathology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, IndiaDepartment of Pathology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, IndiaPurpose: To investigate the clinical, radiological, histopathological features, survival outcomes, and prognostic factors of the rare primary leiomyosarcoma of bone (PBLMS). Methods: This was a retrospective study conducted between the year 2012–2022. 16 patients had biopsy-proven PBLMS out of 632 primary bone sarcomas. Data was collected on patient details, tumor characteristics, treatment, and outcomes. Results: The study included 12 males and 4 females with a median age of 26.5 years. Common sites were femur (62 %), tibia (32 %), and humerus (6 %). Pathological fractures occurred in 19 %. Surgery was the primary treatment-limb salvage in 87.5 %, amputation in 12.5 % of the patients. Neo-adjuvant chemotherapy was given in 3 patients. Adjuvant chemotherapy and radiotherapy were given in 10 and 2 patients, respectively. One patient had local recurrence. Five patients developed distant metastasis. The 5-year OS and EFS rates were 62.5 % and 58.5 %, respectively. Higher tumor grade, local recurrence, and distant metastasis adversely impacted OS (p value < 0.05). Positive margins, pathological fracture, and distant metastasis negatively affected local recurrence. Conclusions: PBLMS is an aggressive sarcoma with high metastatic potential. Early detection and complete surgical resection with negative margins are crucial. The benefit of chemotherapy and radiotherapy remains unclear. Distant metastasis was the most significant adverse prognostic factor for overall survival.http://www.sciencedirect.com/science/article/pii/S2773157X25000086LeiomyosarcomaBone sarcomaSurvivalChemotherapyRadiotherapy |
| spellingShingle | Himanshu Rohela Anila Sharma Vaibhav Sahu Sunil Pasricha Ullas Batra Kundan Singh Chufal Akshay Tiwari Manish Pruthi Gurudutt Gupta Anurag Mehta A decade of insight: Understanding primary Leiomyosarcoma of the bone Journal of Orthopaedic Reports Leiomyosarcoma Bone sarcoma Survival Chemotherapy Radiotherapy |
| title | A decade of insight: Understanding primary Leiomyosarcoma of the bone |
| title_full | A decade of insight: Understanding primary Leiomyosarcoma of the bone |
| title_fullStr | A decade of insight: Understanding primary Leiomyosarcoma of the bone |
| title_full_unstemmed | A decade of insight: Understanding primary Leiomyosarcoma of the bone |
| title_short | A decade of insight: Understanding primary Leiomyosarcoma of the bone |
| title_sort | decade of insight understanding primary leiomyosarcoma of the bone |
| topic | Leiomyosarcoma Bone sarcoma Survival Chemotherapy Radiotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2773157X25000086 |
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