The joint role of systemic immune-inflammation index and geriatric nutritional risk index in cancer survivors and their impact on all-cause mortality
IntroductionThis study aimed to investigate the combined predictive value of the Systemic Immune-Inflammation Index (SII) and the Geriatric Nutritional Risk Index (GNRI) for all-cause mortality in cancer survivors.MethodsUsing NHANES data (1999–2018), 2,969 eligible cancer survivors were categorized...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1587824/full |
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| author | Xiangrui Chen Xiangrui Chen Min Hu Chengluo Hao Jun Li Yunwei Han |
| author_facet | Xiangrui Chen Xiangrui Chen Min Hu Chengluo Hao Jun Li Yunwei Han |
| author_sort | Xiangrui Chen |
| collection | DOAJ |
| description | IntroductionThis study aimed to investigate the combined predictive value of the Systemic Immune-Inflammation Index (SII) and the Geriatric Nutritional Risk Index (GNRI) for all-cause mortality in cancer survivors.MethodsUsing NHANES data (1999–2018), 2,969 eligible cancer survivors were categorized into four groups based on SII and GNRI levels. Mortality risk was assessed through unadjusted and fully adjusted Cox proportional hazards models.ResultsThe combination of low SII and high GNRI was associated with the lowest mortality risk (HR = 1.0, reference). In contrast, high SII and low GNRI significantly increased mortality risk (fully adjusted HR = 6.178, 95% CI: 2.669–14.299). Both unadjusted and adjusted models confirmed that high SII correlated with higher mortality, while low GNRI independently predicted poorer outcomes. Subgroup analyses revealed significant interactions between the SII-GNRI combination and gender/alcohol consumption.DiscussionThe findings highlight SII and GNRI as critical predictors of all-cause mortality in cancer survivors. Their combined assessment may improve risk stratification and guide targeted clinical interventions. |
| format | Article |
| id | doaj-art-60660c3ce6a14201a0c87f459a78713a |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-60660c3ce6a14201a0c87f459a78713a2025-08-20T03:30:19ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-06-011210.3389/fnut.2025.15878241587824The joint role of systemic immune-inflammation index and geriatric nutritional risk index in cancer survivors and their impact on all-cause mortalityXiangrui Chen0Xiangrui Chen1Min Hu2Chengluo Hao3Jun Li4Yunwei Han5Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Oncology, Third People’s Hospital of Zigong, Zigong, ChinaDepartment of Dermatology, Third People’s Hospital of Zigong, Zigong, ChinaDepartment of Oncology, Third People’s Hospital of Zigong, Zigong, ChinaDepartment of Oncology, Third People’s Hospital of Zigong, Zigong, ChinaDepartment of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaIntroductionThis study aimed to investigate the combined predictive value of the Systemic Immune-Inflammation Index (SII) and the Geriatric Nutritional Risk Index (GNRI) for all-cause mortality in cancer survivors.MethodsUsing NHANES data (1999–2018), 2,969 eligible cancer survivors were categorized into four groups based on SII and GNRI levels. Mortality risk was assessed through unadjusted and fully adjusted Cox proportional hazards models.ResultsThe combination of low SII and high GNRI was associated with the lowest mortality risk (HR = 1.0, reference). In contrast, high SII and low GNRI significantly increased mortality risk (fully adjusted HR = 6.178, 95% CI: 2.669–14.299). Both unadjusted and adjusted models confirmed that high SII correlated with higher mortality, while low GNRI independently predicted poorer outcomes. Subgroup analyses revealed significant interactions between the SII-GNRI combination and gender/alcohol consumption.DiscussionThe findings highlight SII and GNRI as critical predictors of all-cause mortality in cancer survivors. Their combined assessment may improve risk stratification and guide targeted clinical interventions.https://www.frontiersin.org/articles/10.3389/fnut.2025.1587824/fullsystemic immune-inflammation indexgeriatric nutritional risk indexcancer survivorsall-cause mortalityDietary Inflammatory IndexNHANES |
| spellingShingle | Xiangrui Chen Xiangrui Chen Min Hu Chengluo Hao Jun Li Yunwei Han The joint role of systemic immune-inflammation index and geriatric nutritional risk index in cancer survivors and their impact on all-cause mortality Frontiers in Nutrition systemic immune-inflammation index geriatric nutritional risk index cancer survivors all-cause mortality Dietary Inflammatory Index NHANES |
| title | The joint role of systemic immune-inflammation index and geriatric nutritional risk index in cancer survivors and their impact on all-cause mortality |
| title_full | The joint role of systemic immune-inflammation index and geriatric nutritional risk index in cancer survivors and their impact on all-cause mortality |
| title_fullStr | The joint role of systemic immune-inflammation index and geriatric nutritional risk index in cancer survivors and their impact on all-cause mortality |
| title_full_unstemmed | The joint role of systemic immune-inflammation index and geriatric nutritional risk index in cancer survivors and their impact on all-cause mortality |
| title_short | The joint role of systemic immune-inflammation index and geriatric nutritional risk index in cancer survivors and their impact on all-cause mortality |
| title_sort | joint role of systemic immune inflammation index and geriatric nutritional risk index in cancer survivors and their impact on all cause mortality |
| topic | systemic immune-inflammation index geriatric nutritional risk index cancer survivors all-cause mortality Dietary Inflammatory Index NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1587824/full |
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